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NPS-2143

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Chemical compound Pharmaceutical compound
NPS-2143
Identifiers
IUPAC name
  • 2-chloro-6-amino)-2-hydroxypropoxy]benzonitrile
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H25ClN2O2
Molar mass408.93 g·mol
3D model (JSmol)
SMILES
  • N#Cc2c(Cl)cccc2OCC(O)CNC(C)(C)Cc3ccc1ccccc1c3
InChI
  • InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
  • Key:PZUJQWHTIRWCID-HXUWFJFHSA-N

NPS-2143 (SB-262,470A) is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents.


See also

References

  1. Nemeth EF, Delmar EG, Heaton WL, Miller MA, Lambert LD, Conklin RL, et al. (October 2001). "Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone". The Journal of Pharmacology and Experimental Therapeutics. 299 (1): 323–31. PMID 11561095.
  2. Marquis RW, Lago AM, Callahan JF, Trout RE, Gowen M, DelMar EG, et al. (July 2009). "Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues". Journal of Medicinal Chemistry. 52 (13): 3982–93. doi:10.1021/jm900364m. PMID 19492813.
  3. Kiefer L, Leiris S, Dodd RH (May 2011). "Novel calcium sensing receptor ligands: a patent survey". Expert Opinion on Therapeutic Patents. 21 (5): 681–98. doi:10.1517/13543776.2011.568479. PMID 21406038. S2CID 27608531.
  4. Breitwieser GE (May 2014). "Pharmacoperones and the calcium sensing receptor: exogenous and endogenous regulators". Pharmacological Research. 83: 30–7. doi:10.1016/j.phrs.2013.11.006. PMID 24291533.
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