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NS102

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NS102
Names
IUPAC name 5-Nitro-6,7,8,9-tetrahydro-1H-benzoindole-2,3-dione 3-oxime
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C12H11N3O4/c16-12-11(14-17)8-5-4-6-7(10(8)13-12)2-1-3-9(6)15(18)19/h4-5,9,17H,1-3H2,(H,13,14,16)Key: FQJXCCSUWTUFRG-UHFFFAOYSA-N
  • InChI=1/C12H11N3O4/c16-12-11(14-17)8-5-4-6-7(10(8)13-12)2-1-3-9(6)15(18)19/h4-5,9,17H,1-3H2,(H,13,14,16)Key: FQJXCCSUWTUFRG-UHFFFAOYAV
SMILES
  • O=C2NC1=C3C(CCCC3)=C(()=O)C=C1/C2=N/O
Properties
Chemical formula C12H11N3O4
Molar mass 261.237 g·mol
Appearance Yellow solid
Solubility in water Insoluble
Solubility in DMSO >3 mg/mL
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

NS102 is a kainate receptor antagonist.

References

  1. NS102 at Sigma-Aldrich
  2. Johansen, Tina H; Drejer, Joergen; Watjen, Frank; Nielsen, Elsebet O (1993). "A novel non-NMDA receptor antagonist shows selective displacement of low-affinity kainate binding". European Journal of Pharmacology. 246 (3): 195–204. doi:10.1016/0922-4106(93)90031-4. PMID 8223944.
  3. Dev KK, Petersen V, Honoré T, Henley JM (1996). "Pharmacology and regional distribution of the binding of 6-nitro-7-sulphamoylbenzo-quinoxaline-2,3-dione to rat brain". J. Neurochem. 67 (6): 2609–12. doi:10.1046/j.1471-4159.1996.67062609.x. PMID 8931496. S2CID 39382212.
Ionotropic glutamate receptor modulators
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor


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