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OXR1
Identifiers
Aliases	OXR1, TLDC3, Nbla00307, oxidation resistance 1, CHEGDD
External IDs	OMIM: 605609; MGI: 2179326; HomoloGene: 24993; GeneCards: OXR1; OMA:OXR1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q23.1 Start 106,270,144 bp End 106,752,694 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 B3.1 Start 41,310,878 bp End 41,724,444 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Pons Achilles tendon lateral nuclear group of thalamus trigeminal ganglion sperm spinal ganglia seminal vesicula Brodmann area 23 corpus epididymis prefrontal cortex Top expressed in medial dorsal nucleus parotid gland subiculum pontine nuclei primary motor cortex habenula medial geniculate nucleus lobe of cerebellum cerebellar vermis inferior colliculi More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity protein binding molecular function Cellular component nucleolus mitochondrion cellular component nucleoplasm intracellular membrane-bounded organelle Biological process negative regulation of neuron apoptotic process response to oxidative stress cellular response to hydroperoxide adult walking behavior neuron apoptotic process negative regulation of cellular response to oxidative stress negative regulation of peptidyl-cysteine S-nitrosylation negative regulation of oxidative stress-induced neuron death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55074 170719 Ensembl ENSG00000164830 ENSMUSG00000022307 UniProt Q8N573 Q4KMM3 RefSeq (mRNA) NM_001198532 NM_001198533 NM_001198534 NM_001198535 NM_018002 NM_181354 NM_001130163 NM_001130164 NM_001130165 NM_001130166 NM_130885 NM_001358976 NM_001358977 NM_001358978 RefSeq (protein) NP_001185461 NP_001185462 NP_001185463 NP_001185464 NP_060472 NP_851999 NP_001123635 NP_001123636 NP_001123637 NP_001123638 NP_570955 NP_001345905 NP_001345906 NP_001345907 Location (UCSC) Chr 8: 106.27 – 106.75 Mb Chr 15: 41.31 – 41.72 Mb PubMed search
Wikidata
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Oxidation resistance protein 1 is a protein that in humans is encoded by the OXR1 gene. Loss of OXR1 function causes decline of the retromer complex.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000164830 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022307 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Volkert MR, Elliott NA, Housman DE (Jan 2001). "Functional genomics reveals a family of eukaryotic oxidation protection genes". Proc Natl Acad Sci U S A. 97 (26): 14530–5. doi:10.1073/pnas.260495897. PMC 18953. PMID 11114193.
6. "Entrez Gene: OXR1 oxidation resistance 1".
7. Wilson KA, Bar S, et al. (Jan 2024). "OXR1 maintains the retromer to delay brain aging under dietary restriction". Nature Communications. 15 (1): 467. Bibcode:2024NatCo..15..467W. doi:10.1038/s41467-023-44343-3. PMC 10784588. PMID 38212606.

Further reading

• Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–8. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
• Durand M, Kolpak A, Farrell T, et al. (2007). "The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins". BMC Cell Biol. 8: 13. doi:10.1186/1471-2121-8-13. PMC 1847813. PMID 17391516.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Elliott NA, Volkert MR (2004). "Stress Induction and Mitochondrial Localization of Oxr1 Proteins in Yeast and Humans". Mol. Cell. Biol. 24 (8): 3180–7. doi:10.1128/MCB.24.8.3180-3187.2004. PMC 381681. PMID 15060142.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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