Ohmecarfentanil - Misplaced Pages

Chemical compound Pharmaceutical compound

Ohmecarfentanil
Legal status


Legal status	CA: Schedule I DE: NpSG (Industrial and scientific use only) UK: Class A
Identifiers
IUPAC name Methyl 1-(2-hydroxy-2-phenylethyl)-3-methyl-4-(N-propanoylanilino)piperidine-4-carboxylate
CAS Number	3R,4R: 791564-68-6
PubChem CID	3R,4R: 10432482 3R,4S: 10071012
ChemSpider	3R,4R: 8607909 3R,4S: 8246552
UNII	3R,4R: PZ5RGN8MR8
Chemical and physical data
Formula	C₂₅H₃₂N₂O₄
Molar mass	424.541 g·mol
3D model (JSmol)	3R,4R: Interactive image 3R,4S: Interactive image
SMILES 3R,4R: CCC(=O)N(C1=CC=CC=C1)2(CCN(C2C)CC(C3=CC=CC=C3)O)C(=O)OC 3R,4S: CCC(=O)N(C1=CC=CC=C1)2(CCN(C2C)CC(C3=CC=CC=C3)O)C(=O)OC
InChI 3R,4R: InChI=1S/C25H32N2O4/c1-4-23(29)27(21-13-9-6-10-14-21)25(24(30)31-3)15-16-26(17-19(25)2)18-22(28)20-11-7-5-8-12-20/h5-14,19,22,28H,4,15-18H2,1-3H3/t19-,22?,25-/m1/s1 Key:HVTQDIBOZUDMTH-PJHDFATGSA-N 3R,4S: InChI=1S/C25H32N2O4/c1-4-23(29)27(21-13-9-6-10-14-21)25(24(30)31-3)15-16-26(17-19(25)2)18-22(28)20-11-7-5-8-12-20/h5-14,19,22,28H,4,15-18H2,1-3H3/t19-,22?,25+/m1/s1 Key:HVTQDIBOZUDMTH-CGPDNSSVSA-N

Ohmecarfentanil (RTI-4614-38), also known as Ohlofentanil, is a mu opioid receptor agonist from the class of fentanyl analogues which was found to be 30,000 times more potent than morphine in the rhesus monkey single dose suppression test. This makes ohmecarfentanil, along with some closely related analogues, among the most potent opioid agonists known at this time, even surpassing lofentanil and ohmefentanyl.

References

Carroll FI, Lewin AH, Mascarella SW, Seltzman HH, Reddy PA (April 2021). "Designer drugs: a medicinal chemistry perspective (II)". Annals of the New York Academy of Sciences. 1489 (1): 48–77. Bibcode:2021NYASA1489...48C. doi:10.1111/nyas.14349. PMID 32396701. S2CID 218617085.

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