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PARP10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DHX, 3HKV
Identifiers
Aliases	PARP10, ARTD10, poly(ADP-ribose) polymerase family member 10
External IDs	OMIM: 609564; MGI: 3712326; HomoloGene: 53133; GeneCards: PARP10; OMA:PARP10 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.3 Start 143,977,153 bp End 144,012,772 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 D3 Start 76,115,374 bp End 76,127,641 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte pancreatic ductal cell right uterine tube spleen appendix lymph node right testis tendon of biceps brachii left testis right lobe of liver Top expressed in granulocyte thymus right kidney mesenteric lymph nodes duodenum lip spleen proximal tubule left lobe of liver submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity K63-linked polyubiquitin modification-dependent protein binding protein binding glycosyltransferase activity NAD+ ADP-ribosyltransferase activity protein ADP-ribosylase activity Cellular component cytoplasm nucleus nucleolus cytosol intracellular membrane-bounded organelle Biological process negative regulation of protein K63-linked ubiquitination protein auto-ADP-ribosylation negative regulation of NF-kappaB transcription factor activity protein ADP-ribosylation negative regulation of fibroblast proliferation negative regulation of gene expression NAD biosynthesis via nicotinamide riboside salvage pathway protein poly-ADP-ribosylation translesion synthesis protein mono-ADP-ribosylation DNA repair cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84875 671535 Ensembl ENSG00000178685 ENSMUSG00000063268 UniProt Q53GL7 Q8CIE4 RefSeq (mRNA) NM_032789 NM_001317895 NM_001163575 NM_001163576 RefSeq (protein) NP_001304824 NP_116178 NP_001157047 NP_001157048 Location (UCSC) Chr 8: 143.98 – 144.01 Mb Chr 15: 76.12 – 76.13 Mb PubMed search
Wikidata
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Poly polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).

References

1. ^ GRCh38: Ensembl release 89: ENSG00000178685 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000063268 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays. 26 (8): 882–93. doi:10.1002/bies.20085. PMID 15273990. S2CID 25024719.
6. ^ "Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10".

Further reading

• Chou HY, Chou HT, Lee SC (2006). "CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10)". J. Biol. Chem. 281 (22): 15201–7. doi:10.1074/jbc.M506745200. PMID 16455663.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Yu M, Schreek S, Cerni C, et al. (2005). "PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation". Oncogene. 24 (12): 1982–93. doi:10.1038/sj.onc.1208410. PMID 15674325. S2CID 13330538.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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