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PGDS

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Protein-coding gene in the species Homo sapiens
HPGDS
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1IYH, 1IYI, 1V40, 2CVD, 2VCQ, 2VCW, 2VCX, 2VCZ, 2VD0, 2VD1, 3EE2, 3KXO, 3VI5, 3VI7, 4EC0, 4EDY, 4EDZ, 4EE0, 5AIS, 5AIV, 5AIX

Identifiers
AliasesHPGDS, GSTS, GSTS1-1, PGD2, PGDS, GSTS1, hematopoietic prostaglandin D synthase
External IDsOMIM: 602598; MGI: 1859384; HomoloGene: 113741; GeneCards: HPGDS; OMA:HPGDS - orthologs
EC number2.5.1.18
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)
Chromosome 4 (human)Genomic location for HPGDSGenomic location for HPGDS
Band4q22.3Start94,298,535 bp
End94,342,876 bp
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)
Chromosome 6 (mouse)Genomic location for HPGDSGenomic location for HPGDS
Band6|6 C1Start65,094,277 bp
End65,121,892 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • placenta

  • Achilles tendon

  • gallbladder

  • synovial membrane

  • amniotic fluid

  • mucosa of transverse colon

  • rectum

  • synovial joint

  • tendon of biceps brachii
Top expressed in
  • genital tubercle

  • primordial germ cell

  • calvaria

  • stroma of bone marrow

  • hair

  • Sertoli cell

  • yolk sac

  • ooblast

  • cornea

  • uterus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27306

54486

Ensembl

ENSG00000163106

ENSMUSG00000029919

UniProt

O60760

Q9JHF7

RefSeq (mRNA)

NM_014485

NM_019455

RefSeq (protein)

NP_055300

NP_062328

Location (UCSC)Chr 4: 94.3 – 94.34 MbChr 6: 65.09 – 65.12 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

PGDS protein is a protein that in humans is encoded by the HPGDS gene.

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000163106Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029919Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O (Oct 1997). "Cloning and crystal structure of hematopoietic prostaglandin D synthase". Cell. 90 (6): 1085–95. doi:10.1016/S0092-8674(00)80374-8. PMID 9323136. S2CID 933875.
  6. Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, Urade Y, Hayaishi O (Dec 1997). "Prostaglandin D synthase in human megakaryoblastic cells". J Biol Chem. 272 (45): 28263–6. doi:10.1074/jbc.272.45.28263. PMID 9353279.
  7. Jowsey IR, Thomson AM, Flanagan JU, Murdock PR, Moore GB, Meyer DJ, Murphy GJ, Smith SA, Hayes JD (Oct 2001). "Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases". Biochem J. 359 (Pt 3): 507–16. doi:10.1042/0264-6021:3590507. PMC 1222171. PMID 11672424.
  8. ^ "Entrez Gene: PGDS prostaglandin D2 synthase, hematopoietic".

Further reading

PDB gallery
  • 1iyh: CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE 1iyh: CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE
  • 1iyi: CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE 1iyi: CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE
  • 1v40: First Inhibitor Complex Structure of Human Hematopoietic Prostaglandin D Synthase 1v40: First Inhibitor Complex Structure of Human Hematopoietic Prostaglandin D Synthase
  • 2cvd: Crystal structure analysis of human hematopoietic prostaglandin D synthase complexed with HQL-79 2cvd: Crystal structure analysis of human hematopoietic prostaglandin D synthase complexed with HQL-79
Prostanoid signaling modulators
Receptor
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor
DP1Tooltip Prostaglandin D2 receptor 1
DP2Tooltip Prostaglandin D2 receptor 2
EP (E2)Tooltip Prostaglandin E2 receptor
EP1Tooltip Prostaglandin EP1 receptor
EP2Tooltip Prostaglandin EP2 receptor
EP3Tooltip Prostaglandin EP3 receptor
EP4Tooltip Prostaglandin EP4 receptor
Unsorted
FP (F)Tooltip Prostaglandin F receptor
IP (I2)Tooltip Prostacyclin receptor
TP (TXA2)Tooltip Thromboxane receptor
Unsorted
Enzyme
(inhibitors)
COX
(PTGS)
PGD2STooltip Prostaglandin D synthase
PGESTooltip Prostaglandin E synthaseHQL-79
PGFSTooltip Prostaglandin F synthaseBimatoprost
PGI2STooltip Prostacyclin synthaseTranylcypromine
TXASTooltip Thromboxane A synthase
Others
See also
Receptor/signaling modulators
Leukotriene signaling modulators
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