Papalia (Italian pronunciation: [papaˈliːa]) is an Italian surname. Notable people with the surname include:
- Adam Papalia, Australian sportscaster
- Anna Papalia (born 1978), American author and educator
- Carmen Papalia (born 1981), Canadian artist
- Melanie Papalia (born 1984), Canadian actress
- Paul Papalia (born 1962), Australian politician
- The Papalia crime family, an Italian–Canadian crime family
- Johnny Papalia (1924–1997), Canadian mobster
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