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Putrescine aminotransferase (EC 2.6.1.82, putrescine-alpha-ketoglutarate transaminase, YgjG, putrescine:alpha-ketoglutarate aminotransferase, PAT, putrescine:2-oxoglutarate aminotransferase, putrescine transaminase) is an enzyme with systematic name butane-1,4-diamine:2-oxoglutarate aminotransferase. This enzyme catalyses the following chemical reaction

putrescine + 2-oxoglutarate ${\displaystyle \rightleftharpoons }$ 1-pyrroline + L-glutamate + H₂O (overall reaction)

(1a) putrescine + 2-oxoglutarate ${\displaystyle \rightleftharpoons }$ 4-aminobutanal + L-glutamate

(1b) 4-aminobutanal ${\displaystyle \rightleftharpoons }$ 1-pyrroline + H₂O (spontaneous)

This enzyme is a pyridoxal-phosphate protein.

References

1. Prieto-Santos MI, Martín-Checa J, Balaña-Fouce R, Garrido-Pertierra A (February 1986). "A pathway for putrescine catabolism in Escherichia coli". Biochimica et Biophysica Acta (BBA) - General Subjects. 880 (2–3): 242–4. doi:10.1016/0304-4165(86)90085-1. PMID 3510672.
2. Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR (August 2005). "Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase". FEBS Letters. 579 (19): 4107–12. doi:10.1016/j.febslet.2005.06.038. PMID 16023116.
3. Samsonova NN, Smirnov SV, Altman IB, Ptitsyn LR (January 2003). "Molecular cloning and characterization of Escherichia coli K12 ygjG gene". BMC Microbiology. 3 (1): 2. doi:10.1186/1471-2180-3-2. PMC 150594. PMID 12617754.

External links

• Putrescine+aminotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 2.6.1