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RAB34
Identifiers
Aliases	RAB34, RAB39, RAH, member RAS oncogene family, NARR
External IDs	OMIM: 610917; MGI: 104606; HomoloGene: 12908; GeneCards: RAB34; OMA:RAB34 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 28,714,281 bp End 28,718,429 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B5|11 46.74 cM Start 78,079,256 bp End 78,083,019 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta left ovary right ovary stromal cell of endometrium canal of the cervix ascending aorta gastric mucosa body of uterus right coronary artery left uterine tube Top expressed in calvaria internal carotid artery vas deferens external carotid artery condyle brown adipose tissue tunica adventitia of aorta fossa iris molar More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTP-dependent protein binding GTPase activity Cellular component cytoplasm vesicle phagocytic vesicle membrane Golgi apparatus membrane Golgi cisterna ruffle membrane phagocytic vesicle perinuclear region of cytoplasm Golgi stack extracellular exosome cytoplasmic vesicle cilium cell projection nucleus nucleolus Biological process antigen processing and presentation phagosome-lysosome fusion phagosome maturation lysosome localization macropinocytosis protein transport protein localization to plasma membrane Golgi to plasma membrane protein transport transport intracellular protein transport cell projection organization Rab protein signal transduction positive regulation of smoothened signaling pathway endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83871 19376 Ensembl ENSG00000109113 ENSMUSG00000002059 UniProt Q9BZG1 P0DI83 Q64008 RefSeq (mRNA) NM_001142624 NM_001142625 NM_001144942 NM_001144943 NM_001256276 NM_001256277 NM_001256278 NM_001256281 NM_031934 NM_001159482 NM_033475 RefSeq (protein) NP_001136096 NP_001136097 NP_001138414 NP_001138415 NP_001243205 NP_001243206 NP_001243207 NP_001243210 NP_114140 NP_001243210.1 NP_001152954 NP_258436 Location (UCSC) Chr 17: 28.71 – 28.72 Mb Chr 11: 78.08 – 78.08 Mb PubMed search
Wikidata
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Ras-related protein Rab-34 is a protein that in humans is encoded by the RAB34 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000109113 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000002059 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sun P, Yamamoto H, Suetsugu S, Miki H, Takenawa T, Endo T (Feb 2003). "Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation". J Biol Chem. 278 (6): 4063–71. doi:10.1074/jbc.M208699200. PMID 12446704.
6. "Entrez Gene: RAB34 RAB34, member RAS oncogene family".

Further reading

• Wang T, Hong W (2003). "Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein". Mol. Biol. Cell. 13 (12): 4317–32. doi:10.1091/mbc.E02-05-0280. PMC 138636. PMID 12475955.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen T, Han Y, Yang M, et al. (2003). "Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis". Biochem. Biophys. Res. Commun. 303 (4): 1114–20. doi:10.1016/S0006-291X(03)00482-0. PMID 12684051.
• Wang T, Wong KK, Hong W (2004). "A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34". Mol. Biol. Cell. 15 (2): 815–26. doi:10.1091/mbc.E03-06-0413. PMC 329395. PMID 14668488.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Colucci AM, Campana MC, Bellopede M, Bucci C (2005). "The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction". Biochem. Biophys. Res. Commun. 334 (1): 128–33. doi:10.1016/j.bbrc.2005.06.067. PMID 15996637.
• Speight P, Silverman M (2005). "Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34". Traffic. 6 (10): 858–65. doi:10.1111/j.1600-0854.2005.00321.x. PMID 16138900.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Coyne CB, Shen L, Turner JR, Bergelson JM (2007). "Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5". Cell Host Microbe. 2 (3): 181–92. doi:10.1016/j.chom.2007.07.003. PMC 2719558. PMID 18005733.

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