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RAB3C
Identifiers
Aliases	RAB3C, member RAS oncogene family
External IDs	OMIM: 612829; MGI: 1914545; HomoloGene: 23420; GeneCards: RAB3C; OMA:RAB3C - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q11.2 Start 58,582,221 bp End 58,859,394 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 D2.1 Start 110,190,721 bp End 110,417,530 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pars compacta pars reticulata Brodmann area 46 middle temporal gyrus superior frontal gyrus Brodmann area 23 superior vestibular nucleus islet of Langerhans postcentral gyrus Top expressed in medial dorsal nucleus ventral tegmental area medial geniculate nucleus subiculum lateral geniculate nucleus superior colliculus dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus dorsal tegmental nucleus anterior amygdaloid area More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding myosin V binding protein binding GTP-dependent protein binding GTPase activity Cellular component perinuclear region of cytoplasm vesicle cytosol plasma membrane membrane synaptic vesicle anchored component of synaptic vesicle membrane endosome Biological process regulation of exocytosis protein transport antigen processing and presentation intracellular protein transport vesicle docking involved in exocytosis protein secretion Rab protein signal transduction protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115827 67295 Ensembl ENSG00000152932 ENSMUSG00000021700 UniProt Q96E17 P62823 RefSeq (mRNA) NM_138453 NM_001317915 NM_023852 NM_001360099 RefSeq (protein) NP_001304844 NP_612462 NP_076341 NP_001347028 Location (UCSC) Chr 5: 58.58 – 58.86 Mb Chr 13: 110.19 – 110.42 Mb PubMed search
Wikidata
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Ras-related protein Rab-3C is a protein that in humans is encoded by the RAB3C gene.

Interactions

Rab3C has been shown to interact with ZWINT.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000152932 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000021700 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cheng H, Ma Y, Ni X, Jiang M, Luo Y, Ying K, Xie Y, Ma Y (Aug 2002). "Cloning, mapping, and characterization of the human Rab3C gene". Biochemical Genetics. 40 (7–8): 263–72. doi:10.1023/A:1019834901190. PMID 12296628. S2CID 10653465.
6. "Entrez Gene: RAB3C RAB3C, member RAS oncogene family".
7. van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters. 582 (19): 2838–42. doi:10.1016/j.febslet.2008.07.012. PMID 18625232. S2CID 30206840.

Further reading

• Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (Jun 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
• Fukuda M (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
• Schlüter OM, Khvotchev M, Jahn R, Südhof TC (Oct 2002). "Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion". The Journal of Biological Chemistry. 277 (43): 40919–29. doi:10.1074/jbc.M203704200. PMID 12167638.
• Uphues I, Chern Y, Eckel J (Dec 1995). "Insulin-dependent translocation of the small GTP-binding protein rab3C in cardiac muscle: studies on insulin-resistant Zucker rats". FEBS Letters. 377 (2): 109–12. doi:10.1016/0014-5793(95)01315-6. PMID 8543030. S2CID 27119138.

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