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RIN1
Identifiers
Aliases	RIN1, Ras and Rab interactor 1
External IDs	OMIM: 605965; MGI: 2385695; HomoloGene: 3170; GeneCards: RIN1; OMA:RIN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.2 Start 66,330,241 bp End 66,336,840 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 5,100,509 bp End 5,107,099 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland tendon of biceps brachii olfactory bulb right hemisphere of cerebellum skin of leg skin of abdomen vena cava nucleus accumbens putamen external globus pallidus Top expressed in nucleus accumbens superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell dorsal striatum hippocampus proper prefrontal cortex olfactory tubercle Amygdala spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytoplasm plasma membrane cytoskeleton membrane cytosol dendrite soma Biological process positive regulation of GTPase activity endocytosis signal transduction memory associative learning negative regulation of synaptic plasticity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9610 225870 Ensembl ENSG00000174791 ENSMUSG00000024883 UniProt Q13671 Q921Q7 RefSeq (mRNA) NM_004292 NM_001363559 NM_001363560 NM_145495 NM_001374051 NM_001374052 RefSeq (protein) NP_004283 NP_001350488 NP_001350489 NP_663470 NP_001360980 NP_001360981 Location (UCSC) Chr 11: 66.33 – 66.34 Mb Chr 19: 5.1 – 5.11 Mb PubMed search
Wikidata
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Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.

Interactions

RIN1 has been shown to interact with HRAS.

Additionally, RIN1 binds and activates ABL family tyrosine kinases.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000174791 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000024883 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Han L, Wong D, Dhaka A, Afar D, White M, Xie W, et al. (Jun 1997). "Protein binding and signaling properties of RIN1 suggest a unique effector function". Proc Natl Acad Sci U S A. 94 (10): 4954–9. Bibcode:1997PNAS...94.4954H. doi:10.1073/pnas.94.10.4954. PMC 24612. PMID 9144171.
6. Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M (May 1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 88 (7): 2913–7. Bibcode:1991PNAS...88.2913C. doi:10.1073/pnas.88.7.2913. PMC 51350. PMID 1849280.
7. "Entrez Gene: RIN1 Ras and Rab interactor 1".
8. Mitin NY, Ramocki Melissa B, Zullo Alfred J, Der Channing J, Konieczny Stephen F, Taparowsky Elizabeth J (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21). United States: 22353–61. doi:10.1074/jbc.M312867200. ISSN 0021-9258. PMID 15031288.
9. Han L, Colicelli J (Mar 1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Mol. Cell. Biol. 15 (3). UNITED STATES: 1318–23. doi:10.1128/mcb.15.3.1318. ISSN 0270-7306. PMC 230355. PMID 7862125.

Further reading

• Dkaha A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, et al. (2003). "The RAS effector RIN1 modulates the formation of aversive memories". J. Neurosci. 23 (3): 748–757. doi:10.1523/JNEUROSCI.23-03-00748.2003. PMC 6741936. PMID 12574403.
• Trowbridge IS, Lesley J, Trotter J, Hyman R (1985). "Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor beta-chain gene". Nature. 315 (6021): 666–9. Bibcode:1985Natur.315..666T. doi:10.1038/315666a0. PMID 3874369. S2CID 20469621.
• Han L, Colicelli J (1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Mol. Cell. Biol. 15 (3): 1318–23. doi:10.1128/mcb.15.3.1318. PMC 230355. PMID 7862125.
• Afar DE, Han L, McLaughlin J, Wong S, Dhaka A, Parmar K, et al. (1997). "Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1". Immunity. 6 (6): 773–82. doi:10.1016/S1074-7613(00)80452-5. PMID 9208849.
• Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1". Dev. Cell. 1 (1): 73–82. doi:10.1016/S1534-5807(01)00008-9. PMID 11703925.
• Wang Y, Waldron RT, Dhaka A, Patel A, Riley MM, Rozengurt E, et al. (2002). "The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins". Mol. Cell. Biol. 22 (3): 916–26. doi:10.1128/MCB.22.3.916-926.2001. PMC 133556. PMID 11784866.
• Murphy GA, Graham SM, Morita S, Reks SE, Rogers-Graham K, Vojtek A, et al. (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation". J. Biol. Chem. 277 (12): 9966–75. doi:10.1074/jbc.M109059200. PMID 11788587.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hu H, Bliss JM, Wang Y, Colicelli J (2005). "RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration". Curr. Biol. 15 (9): 815–23. Bibcode:2005CBio...15..815H. doi:10.1016/j.cub.2005.03.049. PMID 15886098. S2CID 6736561.
• Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Hunker CM, Giambini H, Galvis A, Hall J, Kruk I, Veisaga M, et al. (2006). "Rin1 regulates insulin receptor signal transduction pathways". Exp. Cell Res. 312 (7): 1106–18. doi:10.1016/j.yexcr.2005.12.021. PMID 16457816.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Senda K, Goi T, Hirono Y, Katayama K, Yamaguchi A (2007). "Analysis of RIN1 gene expression in colorectal cancer". Oncol. Rep. 17 (5): 1171–5. doi:10.3892/or.17.5.1171. PMID 17390061.
• Kong C, Su X, Chen PI, Stahl PD (2007). "Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation". J. Biol. Chem. 282 (20): 15294–301. doi:10.1074/jbc.M611538200. PMID 17403676.

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