The Men's quadruple sculls event at the 2010 South American Games was held over March 22 at 11:00.
Medalists
| Gold | Silver | Bronze |
| Alejandro Cucchietti Santiago Fernandez Sebastian Fernandez Cristian Rosso  Argentina
|
Rodolfo Collazo Emiliano Dumestre Jhonatan Esquivel Santiago Menese  Uruguay
|
no medal |
Records
| World Best Time | ||||
|---|---|---|---|---|
| World best time |  Australia
|
5:36.20 | Beijing, China | 2008 |
Results
| Rank | Rowers | Country | Time |
|---|---|---|---|
|
Alejandro Cucchietti, Santiago Fernandez, Sebastian Fernandez, Cristian Rosso | Argentina
|
6:05.68 |
|
Rodolfo Collazo, Emiliano Dumestre, Jhonatan Esquivel, Santiago Menese | Uruguay
|
6:14.48 |
| 3 | Ailson Silva, Roque Zimmermann, Ronaldo Vargas, Thiago Carvalho |  Brazil
|
6:29.34 |