S41 may refer to:
Aircraft
- Blériot-SPAD S.41, a French fighter aircraft
- Short S.41, a British biplane floatplane
- Sikorsky S-41, an American flying boat
Rail and transit
- S41 (Berlin), a line of the Berlin S-Bahn
- S41 (Long Island bus)
- S41 (ZVV), a line of the Zürich S-Bahn
Submarines
- ARA Santa Cruz (S-41), of the Argentine Navy
- Brazilian submarine Humaitá (S41)
- HMS Unseen (S41), of the Royal Navy
- INS Vagir (S41), of the Indian Navy
- USS S-41 (SS-146), of the United States Navy
Music
Sum 41, a Canadian punk rock band
Other uses
- New Jersey Route 73, designated Route S41 until 1953
- S41: In case of fire and/or explosion do not breathe fumes, a safety phrase
- Sulfur-41, an isotope of sulfur
- Xhosa language
- S41, a postcode district in Chesterfield, England
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