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SCAMP3
Identifiers
Aliases	SCAMP3, C1orf3, secretory carrier membrane protein 3
External IDs	OMIM: 606913; MGI: 1346346; HomoloGene: 4164; GeneCards: SCAMP3; OMA:SCAMP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q22 Start 155,255,979 bp End 155,262,430 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F1 Start 89,084,780 bp End 89,090,072 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex stromal cell of endometrium apex of heart left ventricle skin of leg mucosa of transverse colon skin of abdomen gastrocnemius muscle Top expressed in yolk sac right kidney zygote muscle of thigh external carotid artery lens proximal tubule lip internal carotid artery superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase binding Cellular component integral component of membrane extracellular exosome intracellular membrane-bounded organelle membrane Golgi membrane Golgi apparatus trans-Golgi network membrane recycling endosome membrane Biological process protein transport post-Golgi vesicle-mediated transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10067 24045 Ensembl ENSG00000263290 ENSG00000116521 ENSMUSG00000028049 UniProt O14828 O35609 RefSeq (mRNA) NM_005698 NM_052837 NM_011886 NM_001309909 NM_001309910 RefSeq (protein) NP_005689 NP_443069 NP_001296838 NP_001296839 NP_036016 Location (UCSC) Chr 1: 155.26 – 155.26 Mb Chr 3: 89.08 – 89.09 Mb PubMed search
Wikidata
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Secretory carrier-associated membrane protein 3 is a protein that in humans is encoded by the SCAMP3 gene.

Function

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

SCAMP3 has been shown to interact with NEDD4.

References

1. ^ ENSG00000116521 GRCh38: Ensembl release 89: ENSG00000263290, ENSG00000116521 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028049 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E (October 1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Research. 7 (10): 1020–6. doi:10.1101/gr.7.10.1020. PMC 310674. PMID 9331372.
6. Wu TT, Castle JD (July 1998). "Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor". Molecular Biology of the Cell. 9 (7): 1661–74. doi:10.1091/mbc.9.7.1661. PMC 25404. PMID 9658162.
7. ^ "Entrez Gene: SCAMP3 secretory carrier membrane protein 3".
8. Aoh QL, Castle AM, Hubbard CH, Katsumata O, Castle JD (March 2009). "SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling". Molecular Biology of the Cell. 20 (6): 1816–32. doi:10.1091/mbc.E08-09-0894. PMC 2655259. PMID 19158374.

Further reading

• Wu TT, Castle JD (July 1997). "Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs)". Journal of Cell Science. 110 ( Pt 13) (13): 1533–41. doi:10.1242/jcs.110.13.1533. PMID 9224770.
• Singleton DR, Wu TT, Castle JD (September 1997). "Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions". Journal of Cell Science. 110 ( Pt 17) (17): 2099–107. doi:10.1242/jcs.110.17.2099. PMID 9378760.
• Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (April 2000). "SCAMP1 function in endocytosis". The Journal of Biological Chemistry. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• SCAMP3 human gene location in the UCSC Genome Browser.
• SCAMP3 human gene details in the UCSC Genome Browser.

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