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Large neutral amino acids transporter small subunit 2

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(Redirected from SLC7A8) Protein-coding gene in the species Homo sapiens
SLC7A8
Identifiers
AliasesSLC7A8, LAT2, LPI-PC1, solute carrier family 7 member 8
External IDsOMIM: 604235; MGI: 1355323; HomoloGene: 8166; GeneCards: SLC7A8; OMA:SLC7A8 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)
Chromosome 14 (human)Genomic location for SLC7A8Genomic location for SLC7A8
Band14q11.2Start23,125,295 bp
End23,183,674 bp
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)
Chromosome 14 (mouse)Genomic location for SLC7A8Genomic location for SLC7A8
Band14|14 C2Start54,959,666 bp
End55,019,403 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • left uterine tube

  • beta cell

  • gastric mucosa

  • right ovary

  • human kidney

  • left ovary

  • oocyte

  • retinal pigment epithelium

  • decidua
Top expressed in
  • yolk sac

  • epithelium of lens

  • right kidney

  • lip

  • islet of Langerhans

  • gastrula

  • decidua

  • superior frontal gyrus

  • muscle of thigh

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23428

50934

Ensembl

ENSG00000092068

ENSMUSG00000022180

UniProt

Q9UHI5

Q9QXW9

RefSeq (mRNA)

NM_001267036
NM_001267037
NM_012244
NM_182728

NM_016972

RefSeq (protein)

NP_001253965
NP_001253966
NP_036376
NP_877392

NP_058668

Location (UCSC)Chr 14: 23.13 – 23.18 MbChr 14: 54.96 – 55.02 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000092068 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022180 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Borsani G, Bassi MT, Sperandeo MP, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Incerti B, Pepe A, Andria G, Ballabio A, Sebastio G (Mar 1999). "SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance". Nat Genet. 21 (3): 297–301. doi:10.1038/6815. PMID 10080183. S2CID 38960307.
  6. Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (Aug 1999). "Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids". J Biol Chem. 274 (28): 19738–44. doi:10.1074/jbc.274.28.19738. hdl:2445/177123. PMID 10391915.
  7. "Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8".

Further reading

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
(1):
(2):
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(4):
(5):
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SLC11–20
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SLC21–30
(21):
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SLC31–40
(31):
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SLC41–48
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SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders


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