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SLC9B2
Identifiers
Aliases	SLC9B2, NHA2, NHE10, NHEDC2, solute carrier family 9 member B2
External IDs	OMIM: 611789; MGI: 2140077; HomoloGene: 45381; GeneCards: SLC9B2; OMA:SLC9B2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q24 Start 103,019,868 bp End 103,085,829 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G3 Start 135,013,461 bp End 135,051,148 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve prefrontal cortex Achilles tendon tibia Brodmann area 9 cerebellar hemisphere right frontal lobe liver right hemisphere of cerebellum islet of Langerhans Top expressed in body of femur membranous bone Dermatocranium mandible maxilla upper lip embryo embryo epithelium of stomach tibiofemoral joint More reference expression data BioGPS n/a
Gene ontology Molecular function solute:proton antiporter activity antiporter activity monovalent cation:proton antiporter activity lithium:proton antiporter activity sodium:proton antiporter activity identical protein binding Cellular component integral component of membrane membrane mitochondrion mitochondrial inner membrane endosome membrane basolateral plasma membrane synaptic vesicle membrane sperm principal piece plasma membrane mitochondrial membranes intracellular vesicle endosome apical plasma membrane cell junction cytoplasmic vesicle cell projection synapse cilium motile cilium Biological process proton transmembrane transport ion transmembrane transport cation transport ion transport positive regulation of osteoclast development transmembrane transport flagellated sperm motility sodium ion transmembrane transport regulation of insulin secretion involved in cellular response to glucose stimulus clathrin-dependent endocytosis sodium ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 133308 97086 Ensembl ENSG00000164038 ENSMUSG00000037994 UniProt Q86UD5 Q5BKR2 RefSeq (mRNA) NM_001300754 NM_001300756 NM_178833 NM_178877 RefSeq (protein) NP_001287683 NP_001287685 NP_849155 NP_001357128 NP_001357129 NP_001357130 NP_001357131 NP_001357132 NP_001357133 NP_001357134 NP_001357135 NP_001357136 NP_849208 Location (UCSC) Chr 4: 103.02 – 103.09 Mb Chr 3: 135.01 – 135.05 Mb PubMed search
Wikidata
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Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 is a protein that in humans is encoded by the SLC9B2 gene.

Function

Sodium–hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000164038 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000037994 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2".
6. Xiang M, Feng M, Muend S, Rao R (November 2007). "A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension". Proceedings of the National Academy of Sciences of the United States of America. 104 (47): 18677–81. Bibcode:2007PNAS..10418677X. doi:10.1073/pnas.0707120104. PMC 2141836. PMID 18000046.

Further reading

• Kondapalli KC, Kallay LM, Muszelik M, Rao R (October 2012). "Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient". The Journal of Biological Chemistry. 287 (43): 36239–50. doi:10.1074/jbc.M112.403550. PMC 3476291. PMID 22948142.
• Ha BG, Hong JM, Park JY, Ha MH, Kim TH, Cho JY, Ryoo HM, Choi JY, Shin HI, Chun SY, Kim SY, Park EK (July 2008). "Proteomic profile of osteoclast membrane proteins: identification of Na+/H+ exchanger domain containing 2 and its role in osteoclast fusion". Proteomics. 8 (13): 2625–39. doi:10.1002/pmic.200701192. PMID 18600791. S2CID 5494045.
• Huang X, Morse LR, Xu Y, Zahradka J, Sychrová H, Stashenko P, Fan F, Battaglino RA (December 2010). "Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae". Biochimica et Biophysica Acta (BBA) - General Subjects. 1800 (12): 1241–7. doi:10.1016/j.bbagen.2010.08.001. PMC 2967667. PMID 20713131.
• Fuster DG, Zhang J, Shi M, Bobulescu IA, Andersson S, Moe OW (August 2008). "Characterization of the sodium/hydrogen exchanger NHA2". Journal of the American Society of Nephrology. 19 (8): 1547–56. doi:10.1681/ASN.2007111245. PMC 2488271. PMID 18508966.
• Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (June 2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Human Molecular Genetics. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
• Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P (January 2008). "NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts". Bone. 42 (1): 180–92. doi:10.1016/j.bone.2007.09.046. PMC 3593247. PMID 17988971.
• Schushan M, Xiang M, Bogomiakov P, Padan E, Rao R, Ben-Tal N (March 2010). "Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension". Journal of Molecular Biology. 396 (5): 1181–96. doi:10.1016/j.jmb.2009.12.055. PMC 2824056. PMID 20053353.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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