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SMIM20

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Protein-coding gene in the species Homo sapiens
SMIM20
Identifiers
AliasesSMIM20, C4orf52, small integral membrane protein 20, MITRAC7, PNX
External IDsOMIM: 617465; MGI: 1913528; HomoloGene: 82612; GeneCards: SMIM20; OMA:SMIM20 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)
Chromosome 4 (human)Genomic location for SMIM20Genomic location for SMIM20
Band4p15.2Start25,861,830 bp
End25,929,813 bp
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)
Chromosome 5 (mouse)Genomic location for SMIM20Genomic location for SMIM20
Band5|5 C1Start53,424,425 bp
End53,435,882 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • deltoid muscle

  • muscle of leg

  • gastrocnemius muscle

  • tibialis anterior muscle

  • Achilles tendon

  • muscle of thigh

  • quadriceps femoris muscle

  • vastus lateralis muscle

  • biceps brachii
Top expressed in
  • right kidney

  • muscle of thigh

  • soleus muscle

  • otolith organ

  • knee joint

  • utricle

  • gastrocnemius muscle

  • masseter muscle

  • quadriceps femoris muscle

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

389203

66278

Ensembl

ENSG00000250317

ENSMUSG00000061461

UniProt

Q8N5G0

D3Z7Q2

RefSeq (mRNA)

NM_001145432
NM_001394130

NM_001145433

RefSeq (protein)

NP_001138904

NP_001138905

Location (UCSC)Chr 4: 25.86 – 25.93 MbChr 5: 53.42 – 53.44 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Small integral membrane protein (SMIM) 20 is a protein that in humans is encoded by the SMIM20 gene. SMIM20 acts as a prohormone to the peptide hormone phoenixin which was discovered for the first time in 2013 in rodent sensory ganglia.

In the study of the evolution of nervous systems, SMIM20 together with NUCB2 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians, cnidarians, ctenophores, and sponges as well as in choanoflagellates.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000250317 – Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000061461 – Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Small integral membrane protein 20". Retrieved 2014-02-05.
  6. Yosten GL, Lyu RM, Hsueh AJ, Avsian-Kretchmer O, Chang JK, Tullock CW, et al. (February 2013). "A novel reproductive peptide, phoenixin". Journal of Neuroendocrinology. 25 (2): 206–215. doi:10.1111/j.1365-2826.2012.02381.x. PMC 3556183. PMID 22963497.
  7. Yañez-Guerra LA, Thiel D, Jékely G (April 2022). O'Connell M (ed.). "Premetazoan Origin of Neuropeptide Signaling". Molecular Biology and Evolution. 39 (4): msac051. doi:10.1093/molbev/msac051. PMC 9004410. PMID 35277960.
  8. Callier V (3 June 2022). "Brain-Signal Proteins Evolved Before Animals Did". Quanta Magazine. Retrieved 2022-06-03.

Further reading

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