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SPIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NS2, 4H75, 4MZF, 4MZG, 4MZH
Identifiers
Aliases	SPIN1, SPIN, TDRD24, spindlin 1
External IDs	OMIM: 609936; MGI: 109242; HomoloGene: 55983; GeneCards: SPIN1; OMA:SPIN1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.1 Start 88,388,430 bp End 88,478,694 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 A5|13 26.04 cM Start 51,254,916 bp End 51,306,582 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in postcentral gyrus caput epididymis corpus epididymis superior vestibular nucleus middle temporal gyrus entorhinal cortex Brodmann area 23 seminal vesicula renal medulla superior frontal gyrus Top expressed in primary oocyte secondary oocyte zygote fossa condyle motor neuron Paneth cell substantia nigra Rostral migratory stream facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methylated histone binding protein binding Cellular component nucleus spindle nucleolus nucleoplasm cytosol nuclear membrane Biological process multicellular organism development Wnt signaling pathway cell cycle meiosis rRNA transcription gamete generation positive regulation of Wnt signaling pathway positive regulation of transcription, DNA-templated chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10927 20729 Ensembl ENSG00000106723 ENSMUSG00000021395 UniProt Q9Y657 Q61142 RefSeq (mRNA) NM_006717 NM_001283028 NM_001283029 NM_001283030 NM_011462 NM_146043 RefSeq (protein) NP_006708 NP_001269957 NP_001269958 NP_001269959 NP_035592 NP_666155 Location (UCSC) Chr 9: 88.39 – 88.48 Mb Chr 13: 51.25 – 51.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Spindlin-1 is a protein that in humans is encoded by the SPIN1 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000106723 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000021395 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gao Y, Yue W, Zhang P, Li L, Xie X, Yuan H, Chen L, Liu D, Yan F, Pei X (Aug 2005). "Spindlin1, a novel nuclear protein with a role in the transformation of NIH3T3 cells". Biochem Biophys Res Commun. 335 (2): 343–50. doi:10.1016/j.bbrc.2005.07.087. PMID 16098913. S2CID 44944387.
6. "Entrez Gene: SPIN1 spindlin 1".

Further reading

• Oh B, Hwang SY, Solter D, Knowles BB (1997). "Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo". Development. 124 (2): 493–503. doi:10.1242/dev.124.2.493. PMID 9053325.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Jiang F, Zhao Q, Qin L, et al. (2006). "Expression, purification, crystallization and preliminary X-ray analysis of human spindlin1, an ovarian cancer-related protein". Protein Pept. Lett. 13 (2): 203–5. doi:10.2174/092986606775101661. PMID 16472086.
• Zhao Q, Qin L, Jiang F, et al. (2007). "Structure of human spindlin1. Tandem tudor-like domains for cell cycle regulation". J. Biol. Chem. 282 (1): 647–56. doi:10.1074/jbc.M604029200. PMID 17082182.

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