SPQR is Senātus Populusque Rōmānus, Latin for the government of the ancient Roman Republic.
SPQR may also refer to:
Arts and entertainment
- SPQR series, a collection of detective stories set in the time of the Roman Republic
- SPQR: The Empire's Darkest Hour, a computer adventure game set in Ancient Rome
- SPQR (board game), a board wargame
- Steve Perrin's Quest Rules, a generic role-playing game system
- SPQR: A History of Ancient Rome, a 2015 book by Mary Beard
- S.P.Q.R.: 2,000 and a Half Years Ago (1994), an Italian comedy film
- S.P.Q.R., a track on the album Deceit by experimental rock band This Heat
- S. P. Q. R., a record label distributed by London Records
Science and technology
- SPQR tree, a data structure for graph connectivity and planar embeddings
- Small Payload Quick Return, a NASA Ames program for "de-orbiting" small payloads
Other uses
- Quiruvilca Airport (ICAO code), a defunct airport in Peru
- Sebastian Patrick Quintus Rahtz (1955–2016), British digital humanities information professional
- SPQR, in the List of Michelin starred restaurants in San Francisco Bay Area
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