Santangelo is an Italian surname and may refer to:
- Santangelo novels, a series of novels by Jackie Collins
- Santangelo family, a fictional family from the novels
People with the surname
Santangelo
- F. P. Santangelo (born 1967), American professional baseball player
- Mara Santangelo (born 1981), Italian professional tennis player
- George Santangelo, American genomicist
- Matt Santangelo (born 1977), American–Italian professional basketball player
- Alfred E. Santangelo (born 1912), American lawyer and politician
- Enrico Santangelo (born 1963), Italian author and art historian
Santángelo
- Duke of Santángelo, a hereditary title in the Peerage of Spain
- Jorge Cocco Santángelo (born 1936), Argentine painter and professor of art
See also
- Elektra v. Santangelo, a 2005 court case
- San Angelo, Texas
- Sant'Angelo (disambiguation)
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