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Small nucleolar RNA host gene 1 is a non-protein coding RNA that in humans is encoded by the SNHG1 gene.

Function

This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. .

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. "Entrez Gene: Small nucleolar RNA host gene 1". Retrieved 2018-09-04.
3. Tycowski, KT; Shu, MD; Steitz, JA (1 February 1996). "A mammalian gene with introns instead of exons generating stable RNA products". Nature. 379 (6564): 464–6. Bibcode:1996Natur.379..464T. doi:10.1038/379464a0. PMID 8559254. S2CID 4319950.

Further reading

• You J, Fang N, Gu J, Zhang Y, Li X, Zu L, Zhou Q (March 2014). "Noncoding RNA small nucleolar RNA host gene 1 promote cell proliferation in nonsmall cell lung cancer". Indian J Cancer. 51 Suppl 3 (7): e99 – e102. doi:10.4103/0019-509X.154092. PMID 25818744.
• Yu F, Bracken CP, Pillman KA, Lawrence DM, Goodall GJ, Callen DF, Neilsen PM (2015). "p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA". PLOS ONE. 10 (6): e0129190. Bibcode:2015PLoSO..1029190Y. doi:10.1371/journal.pone.0129190. PMC 4465335. PMID 26061048.
• Zhang M, Wang W, Li T, Yu X, Zhu Y, Ding F, Li D, Yang T (May 2016). "Long noncoding RNA SNHG1 predicts a poor prognosis and promotes hepatocellular carcinoma tumorigenesis". Biomed. Pharmacother. 80: 73–79. doi:10.1016/j.biopha.2016.02.036. PMID 27133041.
• Sahu D, Hsu CL, Lin CC, Yang TW, Hsu WM, Ho SY, Juan HF, Huang HC (September 2016). "Co-expression analysis identifies long noncoding RNA SNHG1 as a novel predictor for event-free survival in neuroblastoma". Oncotarget. 7 (36): 58022–58037. doi:10.18632/oncotarget.11158. PMC 5295409. PMID 27517149.
• Zhu H, Zhang L, Yan S, Li W, Cui J, Zhu M, Xia N, Yang Y, Yuan J, Chen X, Luo J, Chen R, Xing R, Lu Y, Wu N (January 2017). "LncRNA16 is a potential biomarker for diagnosis of early-stage lung cancer that promotes cell proliferation by regulating the cell cycle". Oncotarget. 8 (5): 7867–7877. doi:10.18632/oncotarget.13980. PMC 5352366. PMID 27999202.
• Cui Y, Zhang F, Zhu C, Geng L, Tian T, Liu H (March 2017). "Upregulated lncRNA SNHG1 contributes to progression of non-small cell lung cancer through inhibition of miR-101-3p and activation of Wnt/β-catenin signaling pathway". Oncotarget. 8 (11): 17785–17794. doi:10.18632/oncotarget.14854. PMC 5392286. PMID 28147312.
• Shen Y, Liu S, Fan J, Jin Y, Tian B, Zheng X, Fu H (April 2017). "Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions". EMBO Rep. 18 (4): 536–548. doi:10.15252/embr.201643139. PMC 5376760. PMID 28264987.
• Li J, Zhang Z, Xiong L, Guo C, Jiang T, Zeng L, Li G, Wang J (May 2017). "SNHG1 lncRNA negatively regulates miR-199a-3p to enhance CDK7 expression and promote cell proliferation in prostate cancer". Biochem. Biophys. Res. Commun. 487 (1): 146–152. doi:10.1016/j.bbrc.2017.03.169. PMID 28400279.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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