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Space Dementia may refer to:

• "Space Dementia" (song), by Muse
• A fictional mental disorder, mentioned in several works:
  • "Space Madness", a season 1 episode of the animated series The Ren and Stimpy Show
  • Fragile Allegiance, a 1996 PC game
  • "Joyride", a 1999 episode of the TV series The Outer Limits
  • "The Train Job", an episode of the TV series Firefly
  • The feature film Armageddon
  • "Coup by Clam", an episode of the TV series Farscape

• Disambiguation pages