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Sulfur dioxygenase (EC 1.13.11.18, sulfur oxygenase, sulfur:oxygen oxidoreductase) is an enzyme with systematic name S-sulfanylglutathione:oxygen oxidoreductase. This enzyme catalyses the following chemical reaction

sulfur + O₂ + H₂O ${\displaystyle \rightleftharpoons }$ sulfite + 2 H (overall reaction)

(1a) glutathione + sulfur ${\displaystyle \rightleftharpoons }$ S-sulfanylglutathione (spontaneous reaction)

(1b) S-sulfanylglutathione + O₂ + H₂O ${\displaystyle \rightleftharpoons }$ glutathione + sulfite + 2 H

This enzyme contains iron.

In humans, sulfur dioxygenase is needed to detoxify sulfide.

References

1. Suzuki I, Silver M (July 1966). "The initial product and properties of the sulfur-oxidizing enzyme of thiobacilli". Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation. 122 (1): 22–33. doi:10.1016/0926-6593(66)90088-9. PMID 5968172.
2. Rohwerder T, Sand W (July 2003). "The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp". Microbiology. 149 (Pt 7): 1699–710. doi:10.1099/mic.0.26212-0. PMID 12855721.
3. Viscomi C, Burlina AB, Dweikat I, Savoiardo M, Lamperti C, Hildebrandt T, Tiranti V, Zeviani M (August 2010). "Combined treatment with oral metronidazole and N-acetylcysteine is effective in ethylmalonic encephalopathy". Nature Medicine. 16 (8): 869–71. doi:10.1038/nm.2188. hdl:11577/3321433. PMID 20657580.

External links

• Sulfur+dioxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 1.13.11