Tassano is a surname. Notable people with the surname include:
- Cristian Marcelo González Tassano (born 1996), Uruguayan footballer
- Fabian Tassano (born 1963), German-born British economist
- Fortunato Brescia Tassano (d. 1951), Peruvian businessman
- Luis Barrios Tassano (1935-1991), Uruguayan lawyer and diplomat
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