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Tizoxanide

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Tizoxanide
Names
Preferred IUPAC name 2-Hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
Other names Desacetyl-nitazoxanide
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.263.225 Edit this at Wikidata
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15)Key: FDTZUTSGGSRHQF-UHFFFAOYSA-N
  • InChI=1/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15)Key: FDTZUTSGGSRHQF-UHFFFAOYAR
SMILES
  • O=C(Nc1ncc(s1)()=O)c2ccccc2O
Properties
Chemical formula C10H7N3O4S
Molar mass 265.25 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Tizoxanide, also known as desacetyl-nitazoxanide, is a thiazolide and an antiparasitic agent that occurs as a metabolite of nitazoxanide in humans through hydrolysis. Tizoxanide may undergo further metabolism via conjugation into tizoxanide glucuronide.

References

  1. Korba BE, Montero AB, Farrar K, et al. (January 2008). "Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication". Antiviral Res. 77 (1): 56–63. doi:10.1016/j.antiviral.2007.08.005. PMID 17888524.
  2. "Nitazoxanide Prescribing Information" (PDF). Romark Pharmaceuticals. August 2013. pp. 1–5. Retrieved 3 January 2016.
  3. Stockis A, Allemon AM, De Bruyn S, Gengler C (May 2002). "Nitazoxanide pharmacokinetics and tolerability in man using single ascending oral doses". Int J Clin Pharmacol Ther. 40 (5): 213–220. doi:10.5414/cpp40213. PMID 12051573.
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