UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase (EC 6.3.2.37, UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase, D-lysine-adding enzyme) is an enzyme with systematic name UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:D-lysine alpha-ligase (ADP-forming). This enzyme catalyses the following chemical reaction

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysine

\rightleftharpoons

ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-D-lysine

The enzyme from Thermotoga maritima also performs the reaction of EC 6.3.2.7.

References

Boniface A, Bouhss A, Mengin-Lecreulx D, Blanot D (June 2006). "The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity". The Journal of Biological Chemistry. 281 (23): 15680–6. doi:10.1074/jbc.M506311200. PMID 16595662.

External links

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Enzymes: CO CS and CN ligases (EC 6.1-6.3)
6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine
6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase
6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 6.3.2