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VK2809

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Chemical compound Pharmaceutical compound
VK2809
Clinical data
Other namesVK-2809; MB07811
Identifiers
IUPAC name
  • (2R,4S)-4-(3-Chlorophenyl)-2-methyl}-3,5-dimethylphenoxy)methyl]-1,3,2λ-dioxaphosphinan-2-one
CAS Number
DrugBank
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H32ClO5P
Molar mass514.98 g·mol

VK2809 (formerly known as MB07811) is a thyromimetic prodrug whose active form is selective for the THR-β isoform. It is being developed by Viking Therapeutics in a phase II trial for the treatment of nonalcoholic steatohepatitis and is also being investigated for glycogen storage disease type Ia.

In 2023, Viking Therapeutics filed a lawsuit against the developer of ASC41, Chinese company Ascletis BioScience, accusing it of stealing Viking's trade secrets to develop ASC41 which is allegedly similar to, or identical to, VK2809.

References

  1. "VK2809". Viking Therapeutics. Retrieved 15 September 2023.
  2. Alkhouri, Naim (1 February 2020). "Thyromimetics as emerging therapeutic agents for nonalcoholic steatohepatitis: rationale for the development of resmetirom (MGL-3196)". Expert Opinion on Investigational Drugs. 29 (2): 99–101. doi:10.1080/13543784.2020.1708899. ISSN 1354-3784. PMID 31868036.
  3. Zhou, Jin; Waskowicz, Lauren R.; Lim, Andrea; Liao, Xiao-Hui; Lian, Brian; Masamune, Hiroko; Refetoff, Samuel; Tran, Brian; Koeberl, Dwight D.; Yen, Paul M. (1 August 2019). "A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia". Thyroid. 29 (8): 1158–1167. doi:10.1089/thy.2019.0007. ISSN 1050-7256. PMC 6707038. PMID 31337282.
  4. "Viking accuses Chinese biotech of 'ruse' to raid trade secrets and make off with NASH cache". Fierce Biotech. 3 January 2023. Retrieved 2 December 2023.
  5. "Viking Therapeutics accuses competitor of pilfering proprietary information". Chemical & Engineering News. January 9, 2023. Viking infers that ASC41 is Ascletis's version of—if not the same compound as—VK2809
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