Van Hoogstraten is a Dutch toponymic surname, meaning "from Hoogstraten" and may refer to:
- Jacob van Hoogstraten (c. 1460–1527), Flemish Dominican theologian and controversialist
- Dirk van Hoogstraten (1596-1640), Dutch painter
- Samuel Dirksz van Hoogstraten (1627–1678), Dutch painter, poet and author on art theory
- Jan van Hoogstraten (1628–1654), Dutch painter
- For other descendants of Dirk van Hoogstraten, see Van Hoogstraten (family) [nl]
- Willem van Hoogstraten (1884–1965), Dutch violinist and conductor
- Jacob Emil van Hoogstraten (1898–1991), Dutch senior public servant in colonial Indonesia
- Nicholas van Hoogstraten (born 1945), controversial British businessman
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