Misplaced Pages

Utpal Bhadra: Difference between revisions

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Browse history interactively← Previous editContent deleted Content addedVisualWikitext
Revision as of 23:02, 17 August 2020 edit2601:400:8100:2ab0:74d3:8944:8acb:582f (talk)No edit summary← Previous edit Latest revision as of 22:09, 29 September 2024 edit undoDarkNight0917 (talk | contribs)Autopatrolled, Extended confirmed users17,104 edits Adding short description: "Indian scientist"Tag: Shortdesc helper 
(35 intermediate revisions by 19 users not shown)
Line 1: Line 1:
{{Short description|Indian scientist}}
{{POV|date=August 2023}}
{{Use dmy dates|date=July 2019}} {{Use dmy dates|date=July 2019}}
{{Orphan|date=October 2016}} {{Orphan|date=October 2016}}


'''Utpal Bhadra Ph.D., D.Sc., FRS(b+c), FNASc''' a renowned International Scientist, worked earlier as a Senior Principal Scientist ( Deputy Director) in the ] (CCMB), CSIR in ], India. Bhadra is known for his work on ],<ref name=misses>{{cite news|url=http://www.thehindu.com/todays-paper/citys-scientist-couple-misses-nobel-narrowly/article3056451.ece|title=City's scientist couple misses Nobel narrowly|date=4 October 2006|publisher=|work=The Hindu}}</ref> and is a ] and a ] in the United Kingdom in 2016. He is called '''RNAI MAN''' as a nickname in Asia (Biosketch BioAsia). Bhadra, along with his wife, Dr. Manika Pal Bhadra, and Prof. Jim Birchler of the ], invented cossuppression in Animal system in 1997 that was the first example of ] in animal systems.<ref name=misses/> His work published in the "CELL" journal in 1997.He and his wife showed that cosuppression or transgene silencing was also active in nonhomologous transgenes and also involved via mutually related endogenous sequences. <ref>{}</ref> '''Utpal Bhadra''' a retired scientist, worked in the ] (CCMB) in ], India. Bhadra is known for his work on ],<ref name=misses>{{cite news|url=http://www.thehindu.com/todays-paper/citys-scientist-couple-misses-nobel-narrowly/article3056451.ece|title=City's scientist couple misses Nobel narrowly|date=4 October 2006|work=The Hindu}}</ref> and is a ] and a ] in the United Kingdom.


In 2002, they published revolutionary articles establishing that Gene silencing is interconnected both in transcriptional and post transcriptional level via RNAI mutations. In 2004, they also invented that RNAI plays a key and revolutionaries role Heterochromatin formation in animal tumor cells particularly in Cancer in ] that was in the top ten ranking papers for three consecutive years.<ref>{{cite web|url=http://www.thehansindia.com/posts/index/Hyderabad-Tab/2016-05-04/CCMB-scientist-bags-Bharat-Jyoti-Award/225938|title=CCMB scientist bags Bharat Jyoti Award|work=]}}</ref> Bhadra, along with his wife, Manika Pal Bhadra, and Jim Birchler of the ], proved in 1997 that ] occurs in animal systems.<ref name=misses/> His work published in the journal ] was in the top ten ranking for papers for three consecutive years.<ref>{{cite web|url=http://www.thehansindia.com/posts/index/Hyderabad-Tab/2016-05-04/CCMB-scientist-bags-Bharat-Jyoti-Award/225938|title=CCMB scientist bags Bharat Jyoti Award|work=]}}</ref>

Bhadra has been establishing first and spreading knowledge of RNA Interference Technology throughout India and Asia-Pacific countries by delivering the talks in different educational Institutes in Singapore, Taiwan and Japan in early days. Later they synthesized '''PABA organic Nanotube''' for delivery of their invented therapeutics. Bhadra and his wife explored a multiple and versatile tentacles of RNAI and tiny microRNAs in different human diseases against cancer, viral infection , neurological disorders etc.

Based on this long standing contribution in Chemical Industries, On behalf of University of Kalyani, West Bengal Governor awarded him''' ‘ Doctor of Science’ (D.Sc., Honorary causa)''' of Chemical Biology in 2016.


==Education and research career== ==Education and research career==
===Early life and education=== ===Early life and education===
{{BLP unsourced section|date=October 2016}} {{BLP unsourced section|date=October 2016}}
Bhadra was born and raised at Hingal Ganj, a small village in the World largest delta island, India. His father Late Kalipada Bhadra was a Mathematical Giant and Asst. Head Master, Locally he was known to '''"SHIP OF MATHEMATICS''''. Bhadra completed his primary education at Hingalganj. The absence of a scope for further education in his village, he completed his schooling till class twelve from his sister's place at Asansol. Later He got admission in Presidency College, the most leading college in undivided India. for his Bachelor of Science (B, Sc.) degree in 1980. Bhadra was born and raised in a small village in the periphery of Sunderbans, West Bengal, India. His father Late Kalipada Bhadra was an Assistant Head Master of the village school. Bhadra completed his primary education from the village High School in Hingalganj. Due to absence of a scope for further education in his village, he completed his schooling until class twelve from his sister's place in Asansol. He pursued his bachelor's degree from the Presidency College in Zoology, Chemistry and Botany which he completed in 1980.

== Colleage and University days ==
Steps of higher education have two candles College and University. Bhadra got admitted in most Leading and Prestigious College, ''' Presidency College''' among Commonwealth Countries in 1977. He successfully promoted in B.Sc exam and entered in premier university '''University of Calcutta''' for his M.Sc degree in 1980. He scored third highest marks in the University and received the Bronze Medal for standing of his merit.He was selected for ''CSIR Junior Research Fellowship (JRF)'' to continue his PH. D. on the most top notched subject Genetics in the same University in 1982. HE worked on " Transcriptional organization and Dosage compensation in trisomies of ''Drosophila'' on epigenetics regulation in the same department.  The part of his work was published in ''Chromosoma''  and ''Journal of Experimental Biology''. Bhadra also received the '''ISCA''' Award and '''Nehru Centenary British Fellowship''' from the United Kingdom to continue his Ph.D. work in '''London'''. But he continued his Ph.D. in the same department of India.

==Research Opportunities and Challenges==

Bhadra's core discovery on transcriptional organization in trisomies open ups a new vistas in epigenetics. The young faculty '''Dr. James S. Birchler''' (now Fellow AAAS, USA) '''Harvard  University, Massachusetts, USA''' was attracted by these findings the most and invited Bhadra to Join his team in '''Harvard University'''. Immediately he selected Bhadra for a Post Doctoral fellowship to work in his team in 1991. Bhadra Joined his team on year Larter in 1992. Meanwhile Dr. Birchler shifted to '''University of Missouri Columbia , USA''' for a better position. Bhadra Joined in his team. One year later in 1993 his wife '''Dr. Manika Pal-Bhadra''' joined Bhadra's leading team of Birchler Lab.  Earlier, Bhadra and his wife completed two blazing projects with credentials . (1) ''Molecular characterizations of different trans-acting Modifiers and their interacting effect on gene regular'' (2) ''Establishment of the most controversial new model for Dosage Compensation in Drosophila via trans acting modifiers''. Later, they accidentally solved a more innovative and complicated venture for Epigenetics. They established that similar to plants after ten long years they invented that Cosuppression or gene silencing also occurred in Animals  and discovered a magical event of Biology Nonhomologous cosuppression that is beyond the limit of Scientist imagination. Such discovery laid the foundation of his fame world wide and entered the International arena of Science. As a result Bhadra got Invitation of leading countries of Europe  including France in 2000 and delivered his multiple talks creating an opposite notion that more transgenes produces less products in Biology.
In Post Doctoral life Bhadra and his wife published nine articles in top notch journals such as multiple articles in '''CELL, Nature Genetics, Genetics, Current opinion of Genes and Development''' etc.

==Milestones of science and technology==

After rigorous nine years Post doctoral training (Post Ph.D.) in USA,  In 2001 '''WELLCOME TRUST RESEARCH FOUNDATION, United Kingdom''' Sponsored to Bhadra.  Bhadra plan to move to India and he received multiple offers from Different Premier Indian Research Institutes and Ultimately joined '''CSIR CCMB, Hyderabad''' as a Senior Scientist for improving third world Science and spreading the cutting edge technology '''RNA Interference'''. Later 2004, Bhadra was awarded Young Investigator Grand from  '''HFSP, France''' and '''Indo -France Bilateral Science programs''' to continue his innovating research. Later Bhadra was promoted as Sr. Principal Scientist or Deputy Director of the same Institute. Meanwhile Bhadra served as chief consultant and project head of five leading Biopharm industries  for RNA based therapeutic development in India . 

Bhadra was extremely successful in this new environment in CCMB and has been publishing in top notch journals and getting competitive grants from International funding agencies. Bhadra's ability to organize International conferences and networking with top scientists in the world is worthy of appreciation. After joining CCMB in 2001 August, Bhadra was not only brought financial support to CCMB but also strengthened and widened CCMB scientific scope and earned Scientific glamour. He continuously published his articles in top notch journals like '''Mol. Cell, Science, Cell''' from India. these are the top articles in CSIR on that year in India. For such contributions, Bhadra was highly rated in the International Scientific Community. In practical sense, more than hundred RNA Pharma industries were developed world wide based on animal gene silencing and RNAI technology.

==Discovery, innovation and major contribution==

===Transcriptional modifiers and organization===
Bhadra has a keen interest to play and explore with chromosome copy numbers and chromosome dynamics at the molecular level since his budding research life in the University. To hunt the treasure of epigenetic and transcriptional organization, he worked on absence one of the active X chromosome in male and trisomies in different entire autosomal arms in ''Drosophila''.Individuals trisomic for the X chromosome produce the same amount of X-linked products ''in vivo'' as euploid males and females that represent a basal level of organisation like that of autosomes. Bhadra established that the levels of template activity are almost dose dependent, means the template activity of the trisomic autosomes must be viewed as a basal level of expression. Compare to other data Bhadra claimed that some other post transcriptional homeostatic mechanism must exist for autosomal dosage compensation trisomies.

In strong relevances, Bhadra propagated his post doctoral work by molecular characterization of trans-acting modifiers of X chromosomal compensated ''white'' gene and ''copia'' retrotransposons and their molecular interactions on the single target. Bhadra generated four transacting dose dependent modifies ''Low, Inr-a, Wow'' and ''Mow'' progressively on the same ''white'' gene targets. The single to quadruple combinations provided the information on their interaction properties. Bhadra noticed the cumulative effects, cancellation by opposite effects, and epistatic interactions of one modifier with another. In some cases, the combination of two directly correlative effects observed an ''inverse correlative effect'' or vice versa. The quadruple combination still only increases ''white'' expression maximally two to threefold rather than the 􏰁>16􏰄 level expected from independent modifier action.Thus Bhadra established that the overall trend of multiple modifiers is non cumulative in phenotype Therefore multiple biochemical pathways contribute to the phenotype that complicates the genetics interaction.

===Dosage Compensation and sex Determination===
The evolution of heteromorphic sex chromosomes is a direct consequence of the evolution of dosage compensation.

===Gene Silencing and cosuppression===

===RNA Interference and its tentacles===

=== MicroRNA, Early diagnosis and therapies===

===Nanoparticle and oral delivery===

=== RNAi and X inactivation===

==Books==
1) ''RNA : blazing core in Biology'' Cambridge Scholar Press UK (2020)

2) ''MicroRNA:New era for diagnosis and therapy'', Academia Press USA (2020)

===Chapters===

1) In Book : ''RNAI and Gene Silencing'' Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York pp 23-43 (2003).

2) In Book :''Bioresources and Environmental Stresses'' University of Okayama press, Okayama, Japan pp 9-14.(2003) (

3) In Book: ''Proceeding in Cold Spring Harbor Symposium'' 69: 433-438.(2005)

4) In book: ''Blackwell Publishing'', 31 (6): 13A. (2007)

5) In Book: ''CRC Press, California'', USA, pp 123- 148.(2009)

6) In book: ''Application of Nanotechnology in Drug Discovery'' In: InTech Open Science/Open Mind shttp://dx.doi.org/ 10.5772/58412, pp.447-468. (2014)

7) In Book: ''Trends in Animal Biotechnolog'' International Press Corporation, USA (2014).

8) In Book: ''Nanoscience & Technology for Mankind''. The National Academy of Sciences, India, pp.96-110.(2014)

9) In Book : ''InTech (Open Science and Open Minds) RNA Interference'' Editor I.Y. Abdurakhmonov http://dx.doi.org/10.5772 /61975.(2016)

10) In Book: ''InTech (Open Science and Open Minds)Novel Aspects of Amyotrophic Lateral Sclerosis.'' (2016)

11) In Book: ''Basic Biochemistry” Volume 1:pp 1-31 (2017)


==Awards and Honors==
=== Fellowships===

1) '''CSIR – Junior Research Fellow & Sr. Research Fellow''' India (1983–1990)(Selected)

2) '''Nehru Centenary Fellow''', London , United Kingdom ( 1991)

3) '''Senior Post-Doc Fellow''', Division of Bio Sciences, University of Missouri, USA (1992–2001)(Selected)

4) '''Fellow ''' Australian Expert Group of Industrial Study '''(AEGIS)''' (2005)(Elected)

5) '''Fellow''' National Academy of Sciences, India (2006)(Elected)

6) '''Senior International Fellow'''. '''Wellcome Trust''', Cambridge, United Kingdom (2005-2011)(Selected)

7) ''' Fellow''' Royal Society of Chemistry ('''FRSC''', London, United Kingdom)(2016, Elected)

8)'''Fellow''' Royal Society of Biology ('''FRSB''', London, United Kingdom)(2016, Elected)

===Selected Awards===
1) '''Excellent Investigator''', French Academy of Science, France(2003-2008).

2)'''Young Investigator''', Human Frontier Science Program France(2003-2009).

3)'''Ranbaxy Research Award''' for Medical Sciences, India (2010),

4) '''Dr. Radhakrishnan Gold Medal Award''' (GEPRA), India (2013).

5)'''Research Excellence Award''' Indo-Global Education Summit(Indus-Foundation) (2013).

6)'''Life Time Achievement gold medal Award'''(ABAP, India) (2013).

7 )'''13th Wellcome Image Awards''' '''WELLCOME TRUST''', Cambridge United Kingdom (2014)

8) '''14th Wellcome Image Awards''' '''WELLFOME TRUST''', Cambridge, United Kingdom (2015)

9) '''Great Achiever of India''', Integrated Council of India (2017)

10) ''' Bharat Joyti''' India (2017)

==Journal's Editor==

1) Frontier of Genetics (since 2011)

2) Journal of Computational Intelligence in Bioinformatics (JCIB) (since 2013)
3) Journal of Advanced Biomarkers Research (Revotech Press) (2015)

4) Frontiers in Bioscience (2015)

5) Journal of In Silico & In-Vitro Pharmacology (2015)

6) Peertechz Journal of Biological Research and Development (2015)

7)''' Journal of Molecular Biology''' (2016)

8) Journal of Biomarker (2016)

9) Scifed of Chemical Research (2016)

10) Journal of Molecular Biology and Biotechnology (2016)

11) Scifed Journal of Virology (2016)

12) SM Group Open Access eBooks,(2016)

13) '''Nature Scientific Reports''' (2016-2018)

14) ''' Journal of Genetics and DNA Research''' ( 2017)

15) Current Trends in Vaccines and vaccinology (2017)

16) SOJ Microbiology and Infectious Diseases (2017)

17) SM Journal of Carcinogenesis (2017)


==Visiting Professor/Scientist==

1) '''Visiting Professor''' Division of Biological Sciences, University of Missouri August 2002- September 15,2002.

2)'''Visiting Scientist''', University of OSAKA, Japan January 15 -February 1, 2003

3)'''Visiting Scientist''' School of Medicine, University of Missouri, Columbia USA February 1 –May 31, 2003.

4)'''Visiting Professor''' Division of Biological Science, University of Missouri July 1- August 15, 2003

5) '''Visiting Scientist''', Biology Department, Washington University St. Louis, USA July 15- August 15, 2004.

6) '''Visiting Professor''', Division of Biological Science, University of Missouri February 1 2005- March 1, 2005.
7) '''Visiting Scientist''', School of Medicine, University of Cape Town, South Africa July1 to July 15, 2005

8)'''Visiting Professor'''. School of Medicine University of Missouri May 15- June 30, 2005.

9) '''Visiting Professor''', Academia Scinica, University of Taiwan, Taipei, Taiwan February 15 -March 1, 2006

10)'''Visiting Scientist''', CNRS, Montpelier, France, April 15- June 15, 2006

11)'''Visiting Professor''', CNRS, Montpelier, France, May 15 - June 15, 2007

12) '''Visiting Professor''', Tamasek Institute Singapore February 15- March 1 2008.

13) '''Visiting Professor''', Masonic Cancer Center, University of Minnesota, USA April 15 - June 15, 2009.

14)'''Visiting Scientist''', University of Munchen, Munchen, Germany April 15 - June 1, 2010.


==Selected publications==
1. Pal Bhadra M., Bhadra U. and Birchler J. (1997) '''Cell''' 90: 479-490 (IF: 36.36) (Joint First Author)

2. Birchler J. A., Pal Bhadra M. and Bhadra U. (1999). '''Nature Genetics''' 21: 148-151

3. Pal-Bhadra M., Bhadra U. and Birchler J. A. (1999) ''' Cell''' 99: 35-46 (Joint First Author)

4. Pal-Bhadra, M., Bhadra, U. and Birchler, J. A. (2002) '''Molecular Cell''' 9: 315-323 (IF: 14.2) (Joint First Author)

5. Pal- Bhadra et al., (2004) '''Science''' 303: 669-672 (Co corresponding author)

6. Grimaud et al, (2007) ''' Cell''' 124 : 957-971 (Head of joint contributory labs)

7. Sharma et al.,''' Mol. Cell. Biol.''' 30: 3582–3595. (in cover page)

8. Pushpavalli et al., (2013) ''' FASEB Journal''' 28: 655-666 (Corresponding Author)
9. Rana et al.,(2015)''' Journal of Controlled Release''' 200: 167-178

10. Utpal Bhadra et. al., (2015) '''Nature Scientific Reports''' 5:14747 ].(Corresponding author)
11. Asalla et al., (2015) '''Nature Sci. Reports''' 6:27513 ]

12. Reddy et al.,(2016) '''Nature scientific reports''' ].
13. Patel et al.,(2017) '''Nature Scientific reports''' Article number: 4263 (2017)]

14. Utpal Bhadra et al.,(2017)'''Sleep Medicine''' ] Corresponding author



==References== ==References==


{{reflist}} {{reflist}}


Latest revision as of 22:09, 29 September 2024

Indian scientist
The neutrality of this article is disputed. Relevant discussion may be found on the talk page. Please do not remove this message until conditions to do so are met. (August 2023) (Learn how and when to remove this message)

This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions. (October 2016)

Utpal Bhadra a retired scientist, worked in the Centre for Cellular and Molecular Biology (CCMB) in Hyderabad, India. Bhadra is known for his work on RNA interference, and is a Fellow of the Royal Society of Biology and a Fellow of the Royal Society of Chemistry in the United Kingdom.

Bhadra, along with his wife, Manika Pal Bhadra, and Jim Birchler of the University of Missouri, proved in 1997 that gene silencing occurs in animal systems. His work published in the journal Science was in the top ten ranking for papers for three consecutive years.

Education and research career

Early life and education

This section of a biography of a living person does not include any references or sources. Please help by adding reliable sources. Contentious material about living people that is unsourced or poorly sourced must be removed immediately.
Find sources: "Utpal Bhadra" – news · newspapers · books · scholar · JSTOR (October 2016) (Learn how and when to remove this message)

Bhadra was born and raised in a small village in the periphery of Sunderbans, West Bengal, India. His father Late Kalipada Bhadra was an Assistant Head Master of the village school. Bhadra completed his primary education from the village High School in Hingalganj. Due to absence of a scope for further education in his village, he completed his schooling until class twelve from his sister's place in Asansol. He pursued his bachelor's degree from the Presidency College in Zoology, Chemistry and Botany which he completed in 1980.

References

  1. ^ "City's scientist couple misses Nobel narrowly". The Hindu. 4 October 2006.
  2. "CCMB scientist bags Bharat Jyoti Award". The Hans India.

Further reading


Flag of IndiaScientist icon

This article about an Indian scientist is a stub. You can help Misplaced Pages by expanding it.

Categories: