| Revision as of 07:30, 6 January 2006 editA314268 (talk | contribs)2,927 edits →Pathology photo← Previous edit |
Latest revision as of 04:30, 7 December 2024 edit undoDriesmand1 (talk | contribs)43 edits Update Human Anatomy Lecture assignment detailsTag: dashboard.wikiedu.org [2.3] |
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Suggestion: I'd like to see more discussion of the human side of Alzheimer's in this entry. It's good from a clinical point of view, but I'd be interested in reading descriptions and/or anecdotes of what Alzheimer's patients are like in person, and how the disease feels to them and their relatives. Anyone up for this? --] 21:26, 8 Jun 2004 (UTC) |
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Research into the disease may, I'm afraid, be limited due to the fact that the disease impacts people primarily after their prime income generating/tax paying days are over. -- ] |
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:False. Impact has been well-documented to extend well beyond the individual with the ailment for the majority of cases (Prigerson, H. G. (2003) N. Engl. J. Med. 349, 1891-1892). Likewise, unlike many other age-associated disorders, there are no effective treatments that simply cost a lot of money. Rich people are as likely as poor people to get the disease, and the treatments available to rich people are no better than those available to poor people.] 15:22, 18 Aug 2004 (UTC) |
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:'''Costs to society due to Alzheimer's'''. Research into this disease is ongoing and should be ongoing. In fact this disease is costly to society. Alzheimer's disease is quite common and nursing homes are filled with people who have Alzheimer's, are unable to take care of themselves, and need supervision. Also, many Alzheimer's patients live at home and full time caretakers need to be hired to look after them. As the disease progresses, it becomes very debilitating, requiring caretakers to help victims with toilet activities, feeding, and bathing. In the end constant supervision is needed. Long-term care insurance policies are now becoming common because of Alzheimer's as well as other infirmities of old age. ] 09:48, 1 Oct 2004 (UTC) |
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{{WikiProject banner shell|class=B|collapsed=yes|vital=yes|listas=Alzheimer's disease|1= |
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{{WikiProject Neuroscience|importance=High}} |
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{{Reliable sources for medical articles|synonym1=Alzheimer's+disease|synonym2=Alzheimer+disease}} |
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{{Merged-from|Retrogenesis}} |
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| title = Alzheimer’s Disease: A Review |
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| year = 2018 |
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| author = Fymat, Alain L: International Institute of Medicine and Science |
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| url = https://scientiaricerca.com/srcons/pdf/SRCONS-02-00054.pdf |
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On the other hand, they're the most politically active age group -- they've more leisure time. There's a reason politicians in the US and elsewhere don't dare touch pensions, for example. |
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==Wiki Education assignment: Perception== |
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{{dashboard.wikiedu.org assignment | course = Misplaced Pages:Wiki_Ed/New_York_University/Perception_(Spring_2024) | assignments = ] | reviewers = ] | start_date = 2024-01-22 | end_date = 2024-05-11 }} |
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<span class="wikied-assignment" style="font-size:85%;">— Assignment last updated by ] (]) 03:49, 10 May 2024 (UTC)</span> |
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The article incorrectly stated that Alzheimer first identified the symptoms of the disease and therefore (citing the authoritative reference from the historian of the institute where they worked) I took the liberty of making this correction: |
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The symptoms of the disease as a distinct nosologic entity were first identified by Emil Kraepelin, and the characteristic neuropathology was first observed by Alois Alzheimer in 1906. In this sense, the disease was co-discovered by Kraepelin and Alzheimer, who worked in Kraepelin's laboratory. Because of the overwhelming importance Kraepelin attached to finding the neuropathological basis of psychiatric disorders, Kraepelin made the generous decision that the disease would bear the name of Alzheimer (J. Psychiat. Res, 1997, Vol 31, No. 6, pp. 635-643). |
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Hello! I previously edited this article for a course (also affiliated with Wiki Education) and have been keeping tabs on it as much as I could. At the time, I learned that we should avoid using documents such as the DSM to avoid copyright strikes. I noticed that after some edits to this article, the DSM itself is directly cited over a scientific review article discussing it (specifically in the Diagnosis (criteria) section). I wanted to ask about whether we could remove it, or if my understanding was incorrect. I am still learning so I hope this question isn't too bothersome! Thank you in advance! ] (]) 19:15, 15 August 2024 (UTC) |
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== Source - Life span == |
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What's a "nosologic entity"? Is there a simpler alternative term that would do the job? --] |
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:The wikitionary doesn't have it, but Merriam-Webster Online has an entry --] 05:13, 23 Mar 2005 (UTC) |
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Broken link. ] (]) 23:31, 8 May 2024 (UTC) |
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:Thanks for reporting, I've fixed it by replacing the original reference with some newer and more precise ones. ] (]) 22:06, 9 May 2024 (UTC) |
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==References== |
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== "]" listed at ] == |
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This article contains many scientific references in footnote or external link format. IMHO, this is not the best way to cite these studies. I have converted a recently added link (about anticholinesterase treatment) into a reference, and I would strongly suggest that this format is employed in the rest of the article as well. Until the developers develop a good footnote function, I would suggest that the name of the first author and the year of publication are sufficient for linking to a list of references at the bottom of the article, as I've done now. ] | ] 19:59, 5 Sep 2004 (UTC) |
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The redirect <span class="plainlinks"></span> has been listed at ] to determine whether its use and function meets the ]. Readers of this page are welcome to comment on this redirect at '''{{slink|Misplaced Pages:Redirects for discussion/Log/2024 May 21#Brain rot}}''' until a consensus is reached. <!-- Template:RFDNote --> ] (]) 23:27, 21 May 2024 (UTC) |
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== Amyloid beta theory under scrutiny == |
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==Question== |
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is alzihimers non-communicabel |
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just wondering |
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Should the article be updated to reflect the doubts about the amyloid beta plaque theory? The paper on which that theory is based is under investigation for fraud now. Source: |
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:It is not. Alzheimer's is a degenerative disease caused by a genetic predisposition and amplified by various other factors, such as inflammation and vascular dysfunction. Why, are you looking for an excuse not to visit your grandmother? ] | ] 11:01, 14 Nov 2004 (UTC) |
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https://www.science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease ] (]) 19:32, 25 May 2024 (UTC) |
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:As described in ], the consensus seems to be that the alleged manipulation would not invalidate most of the research into the amyloid hypothesis. But since the report and the consequences have garnered significant attention from researchers as well as the general public, it would perhaps be a good improvement to mention it briefly in the ]. What do you think @]? (pinging you since you wrote most of the content covering this investigation). ] (]) 21:30, 2 June 2024 (UTC) |
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==Request for expansion== |
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::Thanks for the ping ... I agree with Bendeguz Acs that the sources indicate the alleged manipulation has little impact on most research, hence is not worthy of mention in the main article. As to whether it warrants a mention in the History section, my approach (particularly for a former ]) is to include only that which has been covered by secondary overall literature reviews -- the Lesne/Ashe issue has not risen to that level yet. Since this article has fallen from FA status, I won't strenuously object if it is added to History, but the standard I prefer is to base History on mention in overall literature reviews of the condition. ] (]) 15:37, 3 June 2024 (UTC) |
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I would like to see some recent research included in this aricle, especially about the stress hormone cortisol. |
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'''Update''': {{u|Bendegúz Ács}} considering this (and the at ]), it seems there is some disagreement as to whether the findings cast doubt upon the prevailing amyloid hypothesis. Considering this is the most highly cited paper ever retracted, perhaps a one- or two- sentence summary at ] is warranted? I'm out of time for today, and although I did (partially) update Lesné, I haven't yet updated ], in case you have time to work there -- I am going to be fairly busy through Friday. Thanks for keeping up with this! I still don't find it necessary to make changes to this article, as we don't overplay the amyloid hypothesis here, and it is covered in detail at the Biochemistry of article. ] (]) 02:50, 5 June 2024 (UTC) |
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:Cortisol is not a major issue. You are free to include material you see fit; I do not have access to the required resources. Misplaced Pages can be a learning experience if you include material that you have found on your quest, as long as it's verifiable and relevant. ] | ] 09:05, 3 Dec 2004 (UTC) |
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:I've also been busy, but I saw you made edits in both of those pages, I've reviewed them and they're great! I agree that ] is a good place to mention the retraction now. ] (]) 09:09, 8 June 2024 (UTC) |
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== question == |
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==Wiki Education assignment: Human Anatomy Lecture== |
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I was informed about stem-cell therapy related to AD. Does anyone have information about it, or any name I could contact about this new research? |
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{{dashboard.wikiedu.org assignment | course = Misplaced Pages:Wiki_Ed/University_of_Dayton/Human_Anatomy_Lecture_(Fall_2024) | assignments = ] | reviewers = ] | start_date = 2024-08-19 | end_date = 2024-12-06 }} |
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<span class="wikied-assignment" style="font-size:85%;">— Assignment last updated by ] (]) 04:30, 7 December 2024 (UTC)</span> |
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:No, this concerns Parkinson's, not Alzheimer's. There is no proof that stem ells would work in AD. ] | ] 03:33, 23 Jan 2005 (UTC) |
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::I recently read something (a heading, yes, no time to read the article) on Google News that would disagree. It's recent, within a day or two, and says something about Brain Stemcells being used to combat Alzheimer's. --] 05:15, 23 Mar 2005 (UTC) |
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:That's experimental, like most unproven theories mentioned in this article. Shall we concentrate on the present management? Stem cells are only used in bone marrow disorders, and the rest is all daydreaming out of therapeutic embarassment. ] | ] 07:49, 23 Mar 2005 (UTC) |
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] |
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== Rewrite for those who need this article -- families, policy makers == |
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There is a danger in starting a rewrite from the medical profession's literature, because of the prevasive effect of drug company studies combined with the medical model's focus primarily on perscription drugs, and primarily after diagnosis. The result is a subtle and pervasive bias in the medical journals' point of view, and adopting it uncritically would threaten to obscure the most useful information that a Misplaced Pages article can provide. |
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The audience that Misplaced Pages's Alzheimer's Disease article serves may include a few merely curious souls who want to know the basics, but far more often information on Alzheimer's is sought by family members struggling with the news of diagnosis of a loved one, or concerned about their own fate in old age, and directly or indirectly perhaps by policy makers. |
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There is a subtly slanted point of view pervasive in the medical literature, including the article on which it is suggested that this article be patterned. Neurological literature is driven by publication of new research studies. And the overwhelming majority of research studies are financed by drug companies hoping to promote costly proprietary treatments for Alzheimer's. Lost in this torrent of publications is the fact that efforts to find a cure have so far proven to provide very modest value at best. |
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Meanwhile, the large gains available in the way of prevention have so far been demonstrated in only a few studies, those for which financing was found with non-company money. Impressive results have been observed with certain NSAIDs, vitamins C and E in combination, and exercise, among others. But these important results have drowned in the flood of publications reported in the journals most consulted by neurologists, which discuss drug company studies of (largely ineffective post-diagnosis) drugs. In reporting these studies, the medical journals adopt a pervasive POV focused on present and possible future profitable medicines. This focus has effectively buried the story about prevention, which is the actual headline. To the extent that medical doctors see their role as providing prescription rather than non-prescription remedies, and as acting only after diagnosis, rather than before, their POV conincides with that of the drug companies. If information isn't about cure after diagnosis, it receives short schrift in the medical journals and in medical practices alike. |
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But for families and individuals who need information on Alzheimer's, prevention and care are the information of greatest value. Prevention and nursing care are salient for families (news they can use) and useful in framing public policy. Information about the present, largely-ineffective proprietary treatements will be provided by almost any health-care professional consulted, and often adopted because not taking the (admittedly near-useless) patent medicines is presented as "doing nothing." |
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Misplaced Pages should not allow the POV that focuses exclusively on these low-value / high-cost treatments to crowd out useful, practical NPOV information that patients and their families desperately need on diagnosis, prognosis, nursing care (whether family provided or otherwise), and especially prevention. |
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Information about the gains in prevention is urgently needed in the debates by public policy makers. As some recent comments point out, most people currently get Alzheimer's if they live long enough. Most are cared for by female relatives, as one inestimable social cost. The remaining nursing-care costs threaten to swamp the social safety net in developed countries, which all have aging populations. Though few, the available studies show that cost-effective prevention works. The information in these studies is more valuable and more important than the many re-hashing drug treatments that have but little effect. |
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:The review I suggested is quite impartial, and does not "rehash drug company studies". Of course the social context should be firmly embedded in the article. You may be shouting at a strawman. ] | ] 22:22, 26 Mar 2005 (UTC) |
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Oops! Sorry. |
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== Famous Sufferers == |
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I believe that Vermont Senator ] is in the early stages of ALzheimer's. It seems to me that is why he is retiring from the US Senate. |
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:Unless he declares this openly, stating that on this page would amount to libel. ] | ] 13:36, 10 July 2005 (UTC) |
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==Pathology photo== |
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The gross image of the "Alzheimer's Brain" appears to be one of ], not Alzheimer's. It is of course possible that this is Alzheimer's degeneration, but it would be an atypical case. I would like to suggest replacing this image with one showing the more typical parietal and medial temporal atrophy pattern associated with Alzheimer's disease. ] 02:53, 6 January 2006 (UTC) |
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:You're totally correct. I've fixed this accordingly. ] (] · ) 07:30, 6 January 2006 (UTC) |
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Hello! I previously edited this article for a course (also affiliated with Wiki Education) and have been keeping tabs on it as much as I could. At the time, I learned that we should avoid using documents such as the DSM to avoid copyright strikes. I noticed that after some edits to this article, the DSM itself is directly cited over a scientific review article discussing it (specifically in the Diagnosis (criteria) section). I wanted to ask about whether we could remove it, or if my understanding was incorrect. I am still learning so I hope this question isn't too bothersome! Thank you in advance! Bharatss-SB (talk) 19:15, 15 August 2024 (UTC)
level-4 vital article is rated B-class on Misplaced Pages's content assessment scale.
This audio file was created from a revision of this page dated 12 September 2008 (2008-09-12), and does not reflect subsequent edits.(Audio help · More spoken articles)
This article was the subject of a Wiki Education Foundation-supported course assignment, between 22 January 2024 and 11 May 2024. Further details are available on the course page. Student editor(s): Eg2619 (article contribs). Peer reviewers: PowdersPOWPOW.
The redirect Brain rot has been listed at redirects for discussion to determine whether its use and function meets the redirect guidelines. Readers of this page are welcome to comment on this redirect at Misplaced Pages:Redirects for discussion/Log/2024 May 21 § Brain rot until a consensus is reached. Based5290 (talk) 23:27, 21 May 2024 (UTC)