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| {{About|a proposed medical condition in alternative medicine|the phenomenon ("leaky gut") whereby the intestine wall exhibits excessive permeability|Intestinal permeability}} | {{About|a proposed medical condition in alternative medicine|the phenomenon ("leaky gut") whereby the intestine wall exhibits excessive permeability|Intestinal permeability}} | ||
| {{Alternative medicine sidebar |diagnoses}} | {{Alternative medicine sidebar |diagnoses}} | ||
| ⚫ | '''Leaky gut syndrome''' is a hypothetical and medically unrecognized condition<ref name=nhs/><ref name=it>{{cite journal |title=Debunking the Myth of 'Leaky Gut Syndrome' |publisher=Canadian Society of Intestinal Research |url=https://badgut.org/information-centre/a-z-digestive-topics/leaky-gut-syndrome/ |journal=Inside Tract |issue=187 |year=2013}}</ref> that is distinct from the scientific phenomenon of ] commonly known as "leaky gut".<ref name=nhs/><ref name="BischoffBarbara2014">{{Cite journal |last1=Bischoff |first1=Stephan C |last2=Barbara |first2=Giovanni |last3=Buurman |first3=Wim |last4=Ockhuizen |first4=Theo |last5=Schulzke |first5=Jörg-Dieter |last6=Serino |first6=Matteo |last7=Tilg |first7=Herbert |last8=Watson |first8=Alastair |last9=Wells |first9=Jerry M |date=2014 |title=Intestinal permeability – a new target for disease prevention and therapy |journal=BMC Gastroenterology |language=en |volume=14 |issue=1 |page=189 |doi=10.1186/s12876-014-0189-7 |doi-access=free |issn=1471-230X |pmc=4253991 |pmid=25407511}}</ref> Claims for the existence of "leaky gut syndrome" as a distinct medical condition come mostly from nutritionists and practitioners of ].<ref name=nhs/><ref name=ttt /><ref name=qw/> Proponents claim that a "leaky gut" causes ] throughout the body that results in a wide range of conditions, including ], ], ], ], ], and ].<ref name=nhs/><ref name=ttt>{{cite journal|doi= 10.1016/j.cgh.2013.07.001|title= Intestinal Permeability Defects: Is It Time to Treat?|year= 2013|last1= Odenwald|first1= Matthew A.|last2= Turner|first2= Jerrold R.|journal= Clinical Gastroenterology and Hepatology|volume= 11|issue= 9|pages= 1075–83|pmid= 23851019|pmc= 3758766}}</ref> There is little evidence to support this hypothesis.<ref name=nhs/><ref name="Quigley2016">{{cite journal |author=Quigley |first=Eamonn Martin |year=2016 |title=Leaky gut - concept or clinical entity? |journal=Curr Opin Gastroenterol |type=Review |volume=32 |issue=2 |pages=74–9 |doi=10.1097/MOG.0000000000000243 |pmid=26760399 |s2cid=40590775}}</ref> | ||
| '''Leaky gut syndrome''' is a hypothetical, medically unrecognized condition.<ref name=nhs/><ref name=it>{{cite journal |title=Debunking the Myth of 'Leaky Gut Syndrome' |publisher=Canadian Society of Intestinal Research |url=https://badgut.org/information-centre/a-z-digestive-topics/leaky-gut-syndrome/ |journal=Inside Tract |issue=187 |year=2013}}</ref> | |||
| ⚫ | ] has described "leaky gut syndrome" as a ] diagnosis and says that its proponents use the alleged condition as an opportunity to sell a number of alternative-health remedies – including diets, herbal preparations, and dietary supplements.<ref name="qw">{{cite web|url= http://www.quackwatch.com/01QuackeryRelatedTopics/fad.html|title= Be Wary of "Fad" Diagnoses|last= Barrett|first= Stephen|author-link = Stephen Barrett|date= 14 March 2009|work= ]|access-date= 24 October 2013}}</ref> Promoters of ] have claimed that the passage of proteins through a "leaky" gut is the cause of autism.<ref name="Kalichman2009">{{cite book|first= Seth C.|last= Kalichman|author-link= Seth Kalichman|title= Denying AIDS: Conspiracy Theories, Pseudoscience, and Human Tragedy|year= 2009|publisher= Springer|isbn= 9780387794761|page= }}</ref> Evidence for claims that a leaky gut causes autism is weak and conflicting.<ref name="RaoGershon2016">{{cite journal |last1=Rao |first1=Meenakshi |last2=Gershon |first2=Michael David |year=2016 |title=The bowel and beyond: the enteric nervous system in neurological disorders |journal=Nat Rev Gastroenterol Hepatol |type=Review |volume=13 |issue=9 |pages=517–28 |doi=10.1038/nrgastro.2016.107 |pmc=5005185 |pmid=27435372}}</ref> | ||
| ⚫ | |||
| ⚫ | ] has described "leaky gut syndrome" as a ] diagnosis and says that its proponents use the alleged condition as an opportunity to sell a number of alternative-health remedies – including diets, herbal preparations, and dietary supplements.<ref name="qw">{{cite web|url= http://www.quackwatch.com/01QuackeryRelatedTopics/fad.html|title= Be Wary of "Fad" Diagnoses|last= Barrett|first= Stephen|author-link = Stephen Barrett|date= 14 March 2009|work= ]|access-date= 24 October 2013}}</ref> |
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| <!--Treatment --> | <!--Treatment --> | ||
| Advocates tout various treatments for "leaky gut syndrome", such as ], ]s, herbal remedies, ]-free foods, and low-], low-sugar, or antifungal diets, but there is little evidence that the treatments offered are of benefit.<ref name="nhs"> | Advocates tout various treatments for "leaky gut syndrome", such as ], ]s, herbal remedies, ]-free foods, and low-], low-sugar, and/or antifungal diets, but there is little evidence that the treatments offered are of benefit.<ref name="nhs"> | ||
| {{cite web|date=26 February 2015|title=Leaky gut syndrome|url=http://www.nhs.uk/conditions/leaky-gut-syndrome/|url-status=dead|archive-url=https://archive.today/20180211020641/https://www.nhs.uk/conditions/leaky-gut-syndrome/|archive-date=2018-02-11|access-date=15 August 2016|publisher=]}} | {{cite web|date=26 February 2015|title=Leaky gut syndrome|url=http://www.nhs.uk/conditions/leaky-gut-syndrome/|url-status=dead|archive-url=https://archive.today/20180211020641/https://www.nhs.uk/conditions/leaky-gut-syndrome/|archive-date=2018-02-11|access-date=15 August 2016|publisher=]}} | ||
| </ref> | </ref> | ||
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| == References == | == References == | ||
| {{Reflist |
{{Reflist}} | ||
| {{Pseudoscience}} | {{Pseudoscience}} | ||
Latest revision as of 17:09, 9 January 2025
Hypothetical medical condition This article is about a proposed medical condition in alternative medicine. For the phenomenon ("leaky gut") whereby the intestine wall exhibits excessive permeability, see Intestinal permeability.
Leaky gut syndrome is a hypothetical and medically unrecognized condition that is distinct from the scientific phenomenon of increased intestinal permeability commonly known as "leaky gut". Claims for the existence of "leaky gut syndrome" as a distinct medical condition come mostly from nutritionists and practitioners of alternative medicine. Proponents claim that a "leaky gut" causes chronic inflammation throughout the body that results in a wide range of conditions, including myalgic encephalomyelitis/chronic fatigue syndrome, rheumatoid arthritis, lupus, migraines, multiple sclerosis, and autism. There is little evidence to support this hypothesis.
Stephen Barrett has described "leaky gut syndrome" as a fad diagnosis and says that its proponents use the alleged condition as an opportunity to sell a number of alternative-health remedies – including diets, herbal preparations, and dietary supplements. Promoters of pseudoscience have claimed that the passage of proteins through a "leaky" gut is the cause of autism. Evidence for claims that a leaky gut causes autism is weak and conflicting.
Advocates tout various treatments for "leaky gut syndrome", such as dietary supplements, probiotics, herbal remedies, gluten-free foods, and low-FODMAP, low-sugar, and/or antifungal diets, but there is little evidence that the treatments offered are of benefit. None have been adequately tested to determine whether they are safe and effective for this purpose. The U.K. National Institute for Health and Care Excellence (NICE) does not recommend the use of any special diets to manage the main symptoms of autism or leaky gut syndrome.
See also
References
- ^ "Leaky gut syndrome". NHS Choices. 26 February 2015. Archived from the original on 2018-02-11. Retrieved 15 August 2016.
- "Debunking the Myth of 'Leaky Gut Syndrome'". Inside Tract (187). Canadian Society of Intestinal Research. 2013.
- Bischoff, Stephan C; Barbara, Giovanni; Buurman, Wim; Ockhuizen, Theo; Schulzke, Jörg-Dieter; Serino, Matteo; Tilg, Herbert; Watson, Alastair; Wells, Jerry M (2014). "Intestinal permeability – a new target for disease prevention and therapy". BMC Gastroenterology. 14 (1): 189. doi:10.1186/s12876-014-0189-7. ISSN 1471-230X. PMC 4253991. PMID 25407511.
- ^ Odenwald, Matthew A.; Turner, Jerrold R. (2013). "Intestinal Permeability Defects: Is It Time to Treat?". Clinical Gastroenterology and Hepatology. 11 (9): 1075–83. doi:10.1016/j.cgh.2013.07.001. PMC 3758766. PMID 23851019.
- ^ Barrett, Stephen (14 March 2009). "Be Wary of "Fad" Diagnoses". Quackwatch. Retrieved 24 October 2013.
- Quigley, Eamonn Martin (2016). "Leaky gut - concept or clinical entity?". Curr Opin Gastroenterol (Review). 32 (2): 74–9. doi:10.1097/MOG.0000000000000243. PMID 26760399. S2CID 40590775.
- Kalichman, Seth C. (2009). Denying AIDS: Conspiracy Theories, Pseudoscience, and Human Tragedy. Springer. p. 167. ISBN 9780387794761.
- Rao, Meenakshi; Gershon, Michael David (2016). "The bowel and beyond: the enteric nervous system in neurological disorders". Nat Rev Gastroenterol Hepatol (Review). 13 (9): 517–28. doi:10.1038/nrgastro.2016.107. PMC 5005185. PMID 27435372.