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| In ], a '''Hydroxymethylglutaryl-CoA reductase''' ({{EC number|1.1.1.88}} is an ] that ] the ] | |||
| '''Hydroxymethylglutaryl-CoA reductase''' ({{EC number|1.1.1.88}}, ''beta-hydroxy-beta-methylglutaryl coenzyme A reductase'', ''beta-hydroxy-beta-methylglutaryl CoA-reductase'', ''3-hydroxy-3-methylglutaryl coenzyme A reductase'', ''hydroxymethylglutaryl coenzyme A reductase'') is an ] with system name ''(R)-mevalonate:NAD<sup>+</sup> oxidoreductase (CoA-acylating)''.<ref>{{cite journal | title = Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA) |author = Fimognari, G.M. and Rodwell, V.W. |journal = Biochemistry |year = 1965 |volume = 4 |pages = 2086–2090 |pmid = }}</ref> This enzyme ] the following ] | |||
| : (R)-mevalonate + CoA + 2 NAD<sup>+</sup> <math>\rightleftharpoons</math> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H<sup>+</sup> | : (R)-mevalonate + CoA + 2 NAD<sup>+</sup> <math>\rightleftharpoons</math> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H<sup>+</sup> | ||
| The 3 ] of this enzyme are (R)-], ], and ], whereas its 3 ] are ], ], and ]. | |||
| This enzyme belongs to the family of ]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''(R)-mevalonate:NAD<sup>+</sup> oxidoreductase (CoA-acylating)'''.<ref>{{cite journal | title = Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA) |author = Fimognari, G.M. and Rodwell, V.W. |journal = Biochemistry |year = 1965 |volume = 4 |pages = 2086–2090 |pmid = }}</ref> Other names in common use include '''beta-hydroxy-beta-methylglutaryl coenzyme A reductase''', '''beta-hydroxy-beta-methylglutaryl CoA-reductase''', '''3-hydroxy-3-methylglutaryl coenzyme A reductase''', and '''hydroxymethylglutaryl coenzyme A reductase'''. | |||
| == References == | == References == | ||
Revision as of 14:50, 31 May 2013
| Hydroxymethylglutaryl-CoA reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.88 | ||||||||
| CAS no. | 37250-24-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88 is an enzyme that catalyzes the chemical reaction
- (R)-mevalonate + CoA + 2 NAD 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H
3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 HThe 3 substrates of this enzyme are (R)-mevalonate, CoA, and NAD, whereas its 3 products are 3-hydroxy-3-methylglutaryl-CoA, NADH, and H.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD oxidoreductase (CoA-acylating). Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl coenzyme A reductase.
References
- Fimognari, G.M. and Rodwell, V.W. (1965). "Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA)". Biochemistry. 4: 2086–2090.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- Hydroxymethylglutaryl-CoA+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)