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Gilles-Éric Séralini
Séralini at a meeting on 4 October 2015
Born	(1960-08-23) 23 August 1960 (age 64) Bône, Algeria (then French Algeria)
Alma mater	University of Montpellier II
Known for	Genetically modified food controversies, Séralini affair
Spouse	Soline Séralini
Children	Two
Awards	Knight of the National Order of Merit
Scientific career
Fields	Endocrinology
Institutions	University of Caen
Thesis	Rôle inhibiteur de l'alphafoetoprotéine sur la fonction génitale du rat (1987)

Gilles-Éric Séralini is a French scientist who has been a professor of molecular biology at the University of Caen since 1991. He is best known for publishing research concluding that genetically modified food is unsafe for consumption; one such study, published in September 2012 in Food and Chemical Toxicology prompted many headlines about the dangers of Roundup Ready corn and the Roundup herbicide. The study was subject to considerable criticism by members of the scientific community and was eventually retracted in what has become known as the Séralini affair. On 24 June 2014 the study was republished without further peer review by Environmental Sciences Europe, in order to give the scientific community long-term access to the study data.

Early life

Seralini was born on 23 August 1960 in Annaba, Algeria (then known as Bône). His father was a telecommunications technician and his mother was a schoolteacher. His family first settled in Thonon-les-Bains, Haute Savoie, and then Nice, France. Seralini obtained his baccalaureate degree at the age of 16.

Scientific career

In 1987, Seralini obtained his doctoral degree from the University of Montpellier II. He then did four years of research at, among other places, the University of Western Ontario and Laval University Medical Center, doing research on corticosteroid-binding globulin, before being appointed a professor at the University of Caen in June 1991, a position he has held ever since. The general area of his lab's research focuses on the endocrine system, in particular the enzyme aromatase, and his lab has synthesized a number of aromatase inhibitors using equine aromatase as a model. In addition to the safety of genetically modified food, Seralini's more recent research has focused on the effects of the glyphosate-based herbicide Roundup on human cells and the enzyme aromatase in vitro, as well as rat testicular cells. In general, this in vitro research has concluded that Roundup (the formulation with adjuvants, not just glyphosate) is toxic to cells in a dish, as well as that it is an endocrine disruptor. The cell lines tested include HUVEC, HEK cells, and placental JEG-3 cells, as well as HepG2 cells. In 2013, the Seralini lab published a study that examines the effects of Cry1ab and Cry1ac insecticidal Bt toxins, as well as their effects in conjunction with Roundup, on HEK cells. His research has been published in the Journal of Histochemistry & Cytochemistry, the Journal of Steroid Biochemistry and Molecular Biology, and Molecular and Cellular Endocrinology.

In 2014, Seralini et al. published a study claiming that pesticides were more toxic than regulatory bodies had previously thought. The study prompted Ralf Reski, one of the editors of BioMed Research International, the journal in which it was published, to resign. Reski said, "I do not want to be connected to a journal that provides a forum for such kind of agitation."

Debate

In May 2013, shortly before a debate was scheduled to take place on the topic of genetically modified foods, held by the libertarian think tank Cato Institute, both Professor Seralini and consumer activist Jeffrey M. Smith withdrew from the debate, with Smith disapproving of the planned inclusion of molecular biologist Kevin Folta and Seralini accusing Jon Entine, who organized the debate's panel, of libel.

Honors

In October 2015, the Federation of German Scientists (VDW) and the German Section of the International Association of Lawyers Against Nuclear Arms (“IALANA”) honoured Séralini with the 2015 Whistleblower Award, noting that the questions raised by Séralini should be further studied, and scientific conclusions should not rely exclusively on data from interested parties.

Selected publications

Scientific papers

• Almadhidi, J.; Seralini, G. E.; Fresnel, J.; Silberzahn, P.; Gaillard, J. L. (1995). "Immunohistochemical localization of cytochrome P450 aromatase in equine gonads". The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 43 (6): 571–577. doi:10.1177/43.6.7769228. PMID 7769228.
• Le Curieux-Belfond, O.; Moslemi, S.; Mathieu, M.; Séralini, G. E. (2001). "Androgen metabolism in oyster Crassostrea gigas: Evidence for 17β-HSD activities and characterization of an aromatase-like activity inhibited by pharmacological compounds and a marine pollutant". The Journal of Steroid Biochemistry and Molecular Biology. 78 (4): 359–366. doi:10.1016/S0960-0760(01)00109-1. PMID 11717006.
• Lemazurier, E.; Sourdaine, P.; Nativelle, C. L.; Plainfossé, B.; Séralini, G. E. (2001). "Aromatase gene expression in the stallion". Molecular and Cellular Endocrinology. 178 (1–2): 133–139. doi:10.1016/S0303-7207(01)00435-X. PMID 11403902.
• "Laboratory Rodent Diets Contain Toxic Levels of Environmental Contaminants: Implications for Regulatory Tests". PLOS. 2015. doi:10.1371/journal.pone.0128429. {{cite journal}}: Unknown parameter |authors= ignored (help)CS1 maint: unflagged free DOI (link)

Books

• Séralini, Gilles-Éric (2004). Ces OGM qui changent le monde. Flammarion Publishing. ISBN 2080800620.
• Séralini, Gilles-Éric (2006). Après nous le déluge ?. Flammarion Publishing. ISBN 2082105490.

References

1. Décret du 30 janvier 2008 portant promotion et nomination
2. Guilhot, Alain (21 November 2012). "Gilles-Eric Seralini: The Rat Man". LeMonde.fr. Retrieved 3 September 2013.
3. "Elsevier Announces Article Retraction from Journal Food and Chemical Toxicology". Elsevier. Retrieved 29 November 2013.
4. Kate Kelland. "Journal withdraws controversial French Monsanto GM study".
5. Cassasus, Barbara (25 June 2014). "Paper claiming GM link with tumours republished". Nature. Retrieved 31 August 2015.
6. "Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize". Environmental Sciences Europe.
7. Cite error: The named reference Liberation was invoked but never defined (see the help page).
8. Séralini, G. E.; Moslemi, S. (2001). "Aromatase inhibitors: Past, present and future". Molecular and Cellular Endocrinology. 178 (1–2): 117–131. doi:10.1016/S0303-7207(01)00433-6. PMID 11403901.
9. ^ Gasnier, C.; Dumont, C.; Benachour, N.; Clair, E.; Chagnon, C.; Séralini, E. (June 2009). "Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines". Toxicology. 262 (3): 184–191. doi:10.1016/j.tox.2009.06.006. ISSN 0300-483X. PMID 19539684.
10. Clair, É.; Mesnage, R.; Travert, C.; Séralini, G. É. (2012). "A glyphosate-based herbicide induces necrosis and apoptosis in mature rat testicular cells in vitro, and testosterone decrease at lower levels". Toxicology in Vitro. 26 (2): 269–279. doi:10.1016/j.tiv.2011.12.009. PMID 22200534.
11. Benachour, N.; Séralini, G. E. (2009). "Glyphosate Formulations Induce Apoptosis and Necrosis in Human Umbilical, Embryonic, and Placental Cells". Chemical Research in Toxicology. 22 (1): 97–105. doi:10.1021/tx800218n. PMID 19105591.
12. Richard, S. M.; Moslemi, S.; Sipahutar, H.; Benachour, N.; Seralini, G. E. (June 2005). "Differential Effects of Glyphosate and Roundup on Human Placental Cells and Aromatase". Environmental health perspectives. 113 (6): 716–720. doi:10.1289/ehp.7728. ISSN 0091-6765. PMC 1257596. PMID 15929894.
13. Benachour, N.; Sipahutar, H.; Moslemi, S.; Gasnier, C.; Travert, C.; Séralini, G. (2007). "Time- and dose-dependent effects of roundup on human embryonic and placental cells". Archives of environmental contamination and toxicology. 53 (1): 126–133. doi:10.1007/s00244-006-0154-8. PMID 17486286.
14. Mesnage, R.; Clair, E.; Gress, S.; Then, C.; Székács, A.; Séralini, G. -E. (2013). "Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide". Journal of Applied Toxicology. 33 (7): 695–699. doi:10.1002/jat.2712. PMID 22337346.
15. Mesnage, Robin (2014). "Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles". BioMed Research International. 2014: 1–8. doi:10.1155/2014/179691. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
16. Kupferschmidt, Kai (10 February 2014). "Pesticide Study Sparks Backlash". Science Insider. Retrieved 16 March 2014.
17. Entine, Jon (29 May 2013). "Anti-GMO Scientist Gilles-Eric Seralini, Activist Jeffrey Smith Withdraw from Food Biotech Debate". Forbes.com. Retrieved 4 September 2013.
18. "(Full) Reasoning of the Jury − for the 2015 Whistleblower Award to − Professor Gilles-Eric Séralini" (PDF). Federation of German Scientists (VDW) and the German Section of the International Association of Lawyers Against Nuclear Arms (IALANA). Retrieved 22 October 2015.
19. "Former US Drone Operator to Get German Whistleblower Award". 2015.

• Biology
• France
• Biography

Template:Persondata

• French molecular biologists
• Living people
• 1960 births
• University of Montpellier alumni
• People from Nice
• University of Caen faculty
• People from Annaba
• Anti-GMO activists