| Revision as of 22:43, 13 November 2007 editLeevanjackson (talk | contribs)Extended confirmed users, Pending changes reviewers6,619 edits cleanup and remove ref task - did this in the past← Previous edit | Latest revision as of 13:22, 6 August 2017 edit undo2602:304:b11e:20c0:3d77:8880:1649:22e9 (talk) ←Blanked the pageTag: talk page blanking | ||
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| from peer review | |||
| * Both "Causes" and "Mechanism" could use some writing tweaks for clarity: | |||
| * "loss of medium spiny neurons, a GABAergic result" -- contextless without at minimum a wikilink to GABA | |||
| * "can lead to dysfunction of the proteosome system. This mitochondrial dysfunction..., the use of "this" isn't terribly clear. Does the aggregation have effects on both the proteasome and the mitochondria, or is the proteasomal deficiency the direct cause of mitochondrial dysfunction? If so, what is the mechanism? | |||
| * There's mention of the "nanotube" idea but no discussion of amyloid itself - this would be a good connection to make with other protein misfolding diseases. | |||
| * The "Genetics" section mentions that repeat number becomes unstable after 35 repeats and causes disease after 40. It should either be briefly explained why the DNA replication machinery has difficulty with repetitive sequences, or at least wikilink to DNA replication so readers can learn about it there. | |||
| * The "Epidemiology" section could use some expansion if the data is available. Is it more prevalent in certain populations or ethnic groups? The prevalence statement also needs a citation, and there are weasel words in the ethics section. | |||
| * Could use another pass to reduce jargon so that non-biologists / doctors are better able to understand it. | |||
| from discussion | |||
| *images/graphs of age of onset, distribution of CAG repeats,maybe the huntingtin molecule - (possibly as main image) | |||
| *it would be much appreciated if something could be added regarding Pre-Implantation Genetic Diagnosis as an option for having children without passing the gene forward. Although there are still ethical considerations, they may be more bearable than the choice to abort or not. | |||