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'''Richard H. Ebright''' is an American ]. He is the Board of Governors Professor of Chemistry and Chemical Biology at ] and Laboratory Director at the ].<ref name="Rutgers">{{cite web |title=Ebright, Richard H. |url=http://chem.rutgers.edu/?q=node/32 |work=Department of Chemistry, Rutgers University |accessdate=October 6, 2011 }}</ref><ref name="Waksman">{{cite web |title=Dr. Richard H. Ebright |url=http://www.waksman.rutgers.edu/ebright/richard-h-ebright |work=Waksman Institute, Rutgers University |accessdate=October 6, 2011 }}</ref> '''Richard H. Ebright''' is an American ]. He is the Board of Governors Professor of Chemistry and Chemical Biology at ] and Laboratory Director at the ].<ref name="Waksman">{{cite web |title=Dr. Richard H. Ebright |url=http://www.waksman.rutgers.edu/ebright/richard-h-ebright |work=Waksman Institute, Rutgers University |accessdate=October 6, 2011 }}</ref><ref name="Rutgers">{{cite web |title=Ebright, Richard H. |url=https://chem.rutgers.edu/people/faculty-bio/140-ebright-richard |work=Department of Chemistry, Rutgers University |accessdate=August 21, 2020 }}</ref>


==Early life and education== ==Early life and education==
Richard H. Ebright was born on 11 June 1959 to Richard J. Ebright and Jacqueline K. Ebright.
Richard H. Ebright was born on 11 June 1959 to Richard J. Ebright and Jacqueline K. Ebright. He grew up north of ], ].<ref name=":0">{{Cite book|last=|first=|url=http://ncert.nic.in/textbook/textbook.htm?jefp1=7-10|title=Footprints Without Feet|last2=|first2=|last3=|first3=|last4=|first4=|last5=|first5=|last6=|first6=|first7=|last8=|first8=|last9=|publisher=NCERT|year=|isbn=|location=|pages=32-37|chapter=The Making of a Scientist}}</ref>


Ebright received an ] '']'' in biology from ] in 1981 and a Ph.D. in Microbiology and Molecular Genetics from ] in 1987. He was a Junior Fellow of the ] from 1984 to 1987.<ref name=":0" /> Ebright received an ] '']'' in biology from ] in 1981 and a Ph.D. in Microbiology and Molecular Genetics from ] in 1987.<ref name="Waksman" /><ref name="Rutgers" /> He was a Junior Fellow of the ] from 1984 to 1987.<ref name="Waksman" />


==Career== ==Career==
Ebright was appointed as a faculty member in the Department of Chemistry at ] and as a Laboratory Director at the ] in 1987. He was co-appointed as an Investigator of the ] from 1997 to 2013. Ebright was appointed as a faculty member in the Department of Chemistry at ] and as a Laboratory Director at the ] in 1987.<ref name="Waksman" /> He was co-appointed as an Investigator of the ] from 1997 to 2013.<ref name="Waksman" />


Ebright has performed research on ],<ref name="Ebright">{{Cite journal Ebright has performed research on ],<ref name="Ebright">{{Cite journal
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| pmid = 23086998 | pmid = 23086998
| pmc = 3593053| volume=338 | issue=6110 | pages=1076–80 | pmc = 3593053| volume=338 | issue=6110 | pages=1076–80
}}</ref><ref name="Kapanidis">{{cite journal |author1=Kapanidis, A. N. |author2=Margeat, E. |author3=Ho, S. O. |author4=Kortkhonjia, E. |author5=Weiss, S. |author6=Ebright, R. H. |year=2006 |title=Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism |journal=Science |volume=314 |pages=1144–1147 |pmid=17110578 |doi=10.1126/science.1131399 |pmc=2754788 }}</ref><ref name="Revyakin">{{cite journal |author1=Revyakin, A. |author2=Liu, C. |author3=Ebright, R. H. |author4=Strick, T. | year = 2006 | title = Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching | url = | journal = Science | volume = 314 | issue = 5802| pages = 1139–1143 | doi = 10.1126/science.1131398 | pmid = 17110577 | pmc = 2754787 | bibcode = 2006Sci...314.1139R }}</ref> ],<ref name="Benoff">{{cite journal |author1=Benoff, B. |author2=Yang, H. |author3=Lawson, C. L. |author4=Parkinson, G. |author5=Liu, J. |author6=Blatter, E. |author7=Ebright, Y. W. |author8=Berman, H. M. |author9=Arnold, E. |author10=Ebright, R. H. |year=2002 |title=Structural basis of transcription activation: the CAP-alphaCTD-DNA complex |journal=Science |volume=297 |issue=5586 |pages=1562–1566 |PMID=12202833 |doi=10.1126/science.1076376 |bibcode=2002Sci...297.1562B }}</ref><ref name="Feng">{{cite journal |author1=Feng, Y. |author2=Zhang, Y. |author3=Ebright, R. H. |year=2016 |title=Structural basis of transcription activation |journal=Science |volume=352 |issue=6291 |pages=1330–1333 |doi=10.1126/science.aaf4417 |pmid= 27284196 |pmc=4905602}}</ref> transcription-translation coupling,<ref name="Wang">{{cite journal |author1=Wang, C. |author2=Molodtsov, V |author3=Firlar, E.|author4=Kaelber, J. |author5=Blaha, G. |author6=Su, M. |author7=Ebright, R. H. |lastauthoramp=yes |year=2020 |title=Structural basis of transcription-translation coupling |journal=Science |doi=10.1126/science.abb5317 |pmid=32820061 }}</ref> and ] drug discovery.<ref name="Mukhopadhyay">{{cite journal |author1=Mukhopadhyay, J. |author2=Das, K. |author3=Ismail, S. |author4=Koppstein, D. |author5=Jang, M. |author6=Hudson, B. |author7=Sarafianos, S. |author8=Tuske, S. |author9=Patel, J. |author10=Jansen, R. |author11=Irschik, H. |author12=Arnold, E. |author13=Ebright, R. H. |lastauthoramp=yes |year=2008 |title=The RNA polymerase "switch region" is a target for inhibitors |journal=Cell |volume=135 |issue=2 |pages=295–307 |doi=10.1016/j.cell.2008.09.033 |pmc=2580802 |pmid=18957204 }}</ref><ref name="GE23077">{{cite journal |author1=Zhang, Y. |author2=Degen, D. |author3=Ho, M. X. |author4=Sineva, E. |author5=Ebright, K. |author6=Ebright, Y. W. |author7=Mekler, V. |author8=Vahedian-Movahed, H. |author9=Feng, Y. |author10=Yin, R. |author11=Tuske, S. |author12=Irschik, H. |author13=Jansen, R. |author14=Maffioli, S. |author15=Donadio, S. |author16=Arnold, E. |author17=Ebright, R. H. | year = 2014 | title = GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides | url = | journal = eLife | volume = 3 | pages = e02450 | doi = 10.7554/eLife.02450 | pmid = 24755292 | pmc = 3994528}}</ref><ref name = "Feng Sal">{{cite journal | last1 = Degen | first1= D. | last2 = Feng | first2 = Y. | last3 = Zhang | first3 = Y. | last4 = Ebright | first4 = K. | last5 = Ebright | first5 = Y. | last6 = Gigliotti | first6 = M. | last7 = Vahedian-Movahed | first7 = H. |last8 = Mandal | first8 = S. | last9 = Talaue | first9 = M. | last10 = Connell | first10 = N. | last11 = Arnold | first11 = E. | last12 = Fenical | first12 = W. | last13 = Ebright | first13 = R. |year = 2014 | title = Transcription inhibition by the depsipeptide antibiotic salinamide A | journal = eLife | volume = 3 | pages = e02451 | doi = 10.7554/eLife.02451 | pmid = 24843001 | pmc = 4029172 }}</ref><ref name="Lin">{{cite journal |author1=Lin, W. |author2=Mandal, S. |author3=Degen, D. |author4=Liu, Y. |author5=Ebright, Y. W. |author6=Li. S. |author7=Feng, Y. |author8=Zhang, Y. |author9=Mandal, S. |author10=Jiang, Y. |author11=Liu, S. |author12=Gigliotti, M. |author13=Talaue, M. |author14=Connell, N. |author15=Das, K. |author16=Arnold, E. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition |journal=Mol. Cell |volume=66 |pages=169–179 |doi=10.1016/j.molcel.2017.03.001 | pmid = 28392175 | pmc = 5438085 }}</ref><ref name="Maffioli">{{cite journal |author1=Maffioli, S. |author2=Zhang, Y. |author3=Degen, D. |author4=Carzaniga, T. |author5=Del Gatto, G. |author6=Serina, S. |author7=Monciardini, P. |author8=Mazzetti, C. |author9=Guglierame, P. |author10=Candiani, G. |author11=Chiriac, A. I. |author12=Facchetti, G. |author13=Kaltofen, P. |author14=Sahl, H.-G. |author15=Dehò, G. |author16=Donadio, S. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase |journal=Cell |volume=169 |issue=7 |pages=1240–1248 |doi=10.1016/j.cell.2017.05.042 |pmid=28622509 |pmc=5542026}}</ref><ref name="Lin2018">{{cite journal |author1=Lin, W. |author2=Das, K. |author3=Degen, D. |author4=Mazumder, A. |author5=Duchi, D. |author6=Wang, D. |author7=Ebright, Y. |author8=Ebright, R.Y. |author9=Sineva, E. |author10=Gigliotti, M. |author11=Srivastava, A. |author12=Mandal, S. |author13=Jiang, Y. |author14=Liu, Y. |author15=Yin, R. |author16=Zhang, Z. |author17=Eng, E. |author18=Thomas, D. |author19=Donadio, S. |author20=Zhang, H. |author21=Zhang, C. |author22=Kapanidis, A. |author23=Ebright, R. H. |lastauthoramp=yes |year=2018 |title=Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3) |journal=Mol. Cell |volume=70 |issue=1 |pages=60–71 |doi=10.1016/j.molcel.2018.02.026 |pmid=29606590|pmc=6205224 }}</ref> Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein–DNA interaction,<ref name="Ebright"/> the determination of the three-dimensional structural organization of the transcription initiation complex;<ref name="Zhang" /> the demonstration that ] involves a "]" mechanism;<ref name="Kapanidis" /><ref name="Revyakin" /> the demonstration that transcription activation can proceed by a "recruitment" mechanism;<ref name="Benoff" /><ref name="Feng" /> the demonstration that bacterial transcription-translation coupling involves direct physical bridging of ] and a ] by NusA and NusG<ref name="Wang" />; and the identification of novel antibacterial drug targets in bacterial RNA polymerase.<ref name="Mukhopadhyay" /><ref name="GE23077" /><ref name="Feng Sal" /><ref name="Lin" /><ref name="Maffioli" /><ref name="Lin2018" /> }}</ref><ref name="Kapanidis">{{cite journal |author1=Kapanidis, A. N. |author2=Margeat, E. |author3=Ho, S. O. |author4=Kortkhonjia, E. |author5=Weiss, S. |author6=Ebright, R. H. |year=2006 |title=Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism |journal=Science |volume=314 |pages=1144–1147 |pmid=17110578 |doi=10.1126/science.1131399 |pmc=2754788 }}</ref><ref name="Revyakin">{{cite journal |author1=Revyakin, A. |author2=Liu, C. |author3=Ebright, R. H. |author4=Strick, T. | year = 2006 | title = Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching | url = | journal = Science | volume = 314 | issue = 5802| pages = 1139–1143 | doi = 10.1126/science.1131398 | pmid = 17110577 | pmc = 2754787 | bibcode = 2006Sci...314.1139R }}</ref> ],<ref name="Benoff">{{cite journal |author1=Benoff, B. |author2=Yang, H. |author3=Lawson, C. L. |author4=Parkinson, G. |author5=Liu, J. |author6=Blatter, E. |author7=Ebright, Y. W. |author8=Berman, H. M. |author9=Arnold, E. |author10=Ebright, R. H. |year=2002 |title=Structural basis of transcription activation: the CAP-alphaCTD-DNA complex |journal=Science |volume=297 |issue=5586 |pages=1562–1566 |PMID=12202833 |doi=10.1126/science.1076376 |bibcode=2002Sci...297.1562B }}</ref><ref name="Feng">{{cite journal |author1=Feng, Y. |author2=Zhang, Y. |author3=Ebright, R. H. |year=2016 |title=Structural basis of transcription activation |journal=Science |volume=352 |issue=6291 |pages=1330–1333 |doi=10.1126/science.aaf4417 |pmid= 27284196 |pmc=4905602}}</ref> transcription-translation coupling,<ref name="Wang">{{cite journal |author1=Wang, C. |author2=Molodtsov, V. |author3=Firlar, E.|author4=Kaelber, J. |author5=Blaha, G. |author6=Su, M. |author7=Ebright, R. H. |lastauthoramp=yes |year=2020 |title=Structural basis of transcription-translation coupling |journal=Science |doi=10.1126/science.abb5317 |pmid=32820061 }}</ref> and ] drug discovery.<ref name="Mukhopadhyay">{{cite journal |author1=Mukhopadhyay, J. |author2=Das, K. |author3=Ismail, S. |author4=Koppstein, D. |author5=Jang, M. |author6=Hudson, B. |author7=Sarafianos, S. |author8=Tuske, S. |author9=Patel, J. |author10=Jansen, R. |author11=Irschik, H. |author12=Arnold, E. |author13=Ebright, R. H. |lastauthoramp=yes |year=2008 |title=The RNA polymerase "switch region" is a target for inhibitors |journal=Cell |volume=135 |issue=2 |pages=295–307 |doi=10.1016/j.cell.2008.09.033 |pmc=2580802 |pmid=18957204 }}</ref><ref name="GE23077">{{cite journal |author1=Zhang, Y. |author2=Degen, D. |author3=Ho, M. X. |author4=Sineva, E. |author5=Ebright, K. |author6=Ebright, Y. W. |author7=Mekler, V. |author8=Vahedian-Movahed, H. |author9=Feng, Y. |author10=Yin, R. |author11=Tuske, S. |author12=Irschik, H. |author13=Jansen, R. |author14=Maffioli, S. |author15=Donadio, S. |author16=Arnold, E. |author17=Ebright, R. H. | year = 2014 | title = GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides | url = | journal = eLife | volume = 3 | pages = e02450 | doi = 10.7554/eLife.02450 | pmid = 24755292 | pmc = 3994528}}</ref><ref name = "Feng Sal">{{cite journal | last1 = Degen | first1= D. | last2 = Feng | first2 = Y. | last3 = Zhang | first3 = Y. | last4 = Ebright | first4 = K. | last5 = Ebright | first5 = Y. | last6 = Gigliotti | first6 = M. | last7 = Vahedian-Movahed | first7 = H. |last8 = Mandal | first8 = S. | last9 = Talaue | first9 = M. | last10 = Connell | first10 = N. | last11 = Arnold | first11 = E. | last12 = Fenical | first12 = W. | last13 = Ebright | first13 = R. |year = 2014 | title = Transcription inhibition by the depsipeptide antibiotic salinamide A | journal = eLife | volume = 3 | pages = e02451 | doi = 10.7554/eLife.02451 | pmid = 24843001 | pmc = 4029172 }}</ref><ref name="Lin">{{cite journal |author1=Lin, W. |author2=Mandal, S. |author3=Degen, D. |author4=Liu, Y. |author5=Ebright, Y. W. |author6=Li. S. |author7=Feng, Y. |author8=Zhang, Y. |author9=Mandal, S. |author10=Jiang, Y. |author11=Liu, S. |author12=Gigliotti, M. |author13=Talaue, M. |author14=Connell, N. |author15=Das, K. |author16=Arnold, E. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition |journal=Mol. Cell |volume=66 |pages=169–179 |doi=10.1016/j.molcel.2017.03.001 | pmid = 28392175 | pmc = 5438085 }}</ref><ref name="Maffioli">{{cite journal |author1=Maffioli, S. |author2=Zhang, Y. |author3=Degen, D. |author4=Carzaniga, T. |author5=Del Gatto, G. |author6=Serina, S. |author7=Monciardini, P. |author8=Mazzetti, C. |author9=Guglierame, P. |author10=Candiani, G. |author11=Chiriac, A. I. |author12=Facchetti, G. |author13=Kaltofen, P. |author14=Sahl, H.-G. |author15=Dehò, G. |author16=Donadio, S. |author17=Ebright, R. H. |lastauthoramp=yes |year=2017 |title=Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase |journal=Cell |volume=169 |issue=7 |pages=1240–1248 |doi=10.1016/j.cell.2017.05.042 |pmid=28622509 |pmc=5542026}}</ref><ref name="Lin2018">{{cite journal |author1=Lin, W. |author2=Das, K. |author3=Degen, D. |author4=Mazumder, A. |author5=Duchi, D. |author6=Wang, D. |author7=Ebright, Y. |author8=Ebright, R.Y. |author9=Sineva, E. |author10=Gigliotti, M. |author11=Srivastava, A. |author12=Mandal, S. |author13=Jiang, Y. |author14=Liu, Y. |author15=Yin, R. |author16=Zhang, Z. |author17=Eng, E. |author18=Thomas, D. |author19=Donadio, S. |author20=Zhang, H. |author21=Zhang, C. |author22=Kapanidis, A. |author23=Ebright, R. H. |lastauthoramp=yes |year=2018 |title=Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3) |journal=Mol. Cell |volume=70 |issue=1 |pages=60–71 |doi=10.1016/j.molcel.2018.02.026 |pmid=29606590|pmc=6205224 }}</ref> Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein–DNA interaction,<ref name="Ebright"/> the determination of the three-dimensional structural organization of the transcription initiation complex;<ref name="Zhang" /> the demonstration that ] involves a "]" mechanism;<ref name="Kapanidis" /><ref name="Revyakin" /> the demonstration that transcription activation can proceed by a "recruitment" mechanism;<ref name="Benoff" /><ref name="Feng" /> the demonstration that bacterial transcription-translation coupling involves direct physical bridging of ] and a ] by NusA and NusG<ref name="Wang" />; and the identification of novel antibacterial drug targets in bacterial RNA polymerase.<ref name="Mukhopadhyay" /><ref name="GE23077" /><ref name="Feng Sal" /><ref name="Lin" /><ref name="Maffioli" /><ref name="Lin2018" />


In 1994 Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation.<ref name="ASBMB">{{cite web |title=ASBMB/Schering-Plough Research Institute Award |url=http://www.asbmb.org/Page.aspx?id=510 |accessdate=October 8, 2011 }}</ref> In 1995 he received the Academic Press Walter J. Johnson Prize.<ref>{{Cite journal In 1994 Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation.<ref name="ASBMB">{{cite web |title=ASBMB/Schering-Plough Research Institute Award |url=http://www.asbmb.org/Page.aspx?id=510 |accessdate=October 8, 2011 }}</ref> In 1995 he received the Academic Press Walter J. Johnson Prize.<ref>{{Cite journal
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Ebright has opposed the proliferation of laboratories working on ] agents<ref>{{cite journal |last1=Connell |first1=N. |last2=Ebright |first2=R. H. |year=2002 |title=Bioweapon agents: more access means more risk |journal=Nature |volume=415 |pages=364 |pmid=11807521 |doi=10.1038/415364b |issue=6870 | bibcode = 2002Natur.415..364E |doi-access=free }}</ref> and has supported the strengthening of ] and ] measures to reduce risks of release of ].<ref>{{cite journal |last=Ebright |first=R. H. |year=2012 |title=Mitigate the risks of release |journal=Nature |volume=481 |pages=257–259 |pmid=22246325 |doi=10.1038/481257a|pmc=7095491 }}</ref> Ebright has opposed the proliferation of laboratories working on ] agents<ref>{{cite journal |last1=Connell |first1=N. |last2=Ebright |first2=R. H. |year=2002 |title=Bioweapon agents: more access means more risk |journal=Nature |volume=415 |pages=364 |pmid=11807521 |doi=10.1038/415364b |issue=6870 | bibcode = 2002Natur.415..364E |doi-access=free }}</ref> and has supported the strengthening of ] and ] measures to reduce risks of release of ].<ref>{{cite journal |last=Ebright |first=R. H. |year=2012 |title=Mitigate the risks of release |journal=Nature |volume=481 |pages=257–259 |pmid=22246325 |doi=10.1038/481257a|pmc=7095491 }}</ref>
==Notable publications==
* {{cite journal | last1 = Ebright | first1 = R. | last2 = Cossart | first2 = P. | last3 = Gicquel-Sanzey | first3 = B. | last4 = Beckwith | first4 = J. | year = 1984 | title = Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli | url = | journal = Nature | volume = 311 | issue = 5983| pages = 232–235 | doi = 10.1038/311232a0 | pmid = 6090927 }}
* {{cite journal | last1 = Blatter | first1 = E. | last2 = Ebright | first2 = Y. | last3 = Ebright | first3 = R. | year = 1992 | title = Identification of an amino acid-base contact in the GCN4-DNA complex by bromouracil-mediated photocrosslinking | url = | journal = Nature | volume = 359 | issue = 6396| pages = 650–652 | doi = 10.1038/359650a0 | pmid = 1406998 }}
* {{cite journal | last1 = Heyduk | first1 = T. | last2 = Lee | first2 = J. | last3 = Ebright | first3 = Y. | last4 = Blatter | first4 = E. | last5 = Zhou | first5 = Y. | last6 = Ebright | first6 = R. | year = 1993 | title = CAP interacts with RNA polymerase in solution in the absence of promoter DNA | url = | journal = Nature | volume = 364 | issue = 6437| pages = 548–549 | doi = 10.1038/364548a0 | pmid = 8393148 }}
* {{cite journal | last1 = Zhou | first1 = Y. | last2 = Busby | first2 = S. | last3 = Ebright | first3 = R. | year = 1993 | title = Identification of the functional subunit of a dimeric transcription activator protein by use of "oriented heterodimers | url = | journal = Cell | volume = 73 | issue = 2| pages = 375–379 | doi = 10.1016/0092-8674(93)90236-J | pmid = 8477449 }}
* {{cite journal | last1 = Chen | first1 = Y. | last2 = Ebright | first2 = Y. | last3 = Ebright | first3 = R. | year = 1994 | title = Identification of the target of a transcription activator protein by protein-protein photocrosslinking | url = | journal = Science | volume = 265 | issue = 5168| pages = 90–92 | doi = 10.1126/science.8016656 | pmid = 8016656 }}
* {{cite journal | last1 = Blatter | first1 = E. | last2 = Ross | first2 = W. | last3 = Tang | first3 = H. | last4 = Gourse | first4 = R. | last5 = Ebright | first5 = R. | year = 1994 | title = Domain organization of RNA polymerase α subunit: C-terminal 85 amino acids constitute a domain capable of dimerization and DNA binding | url = | journal = Cell | volume = 78 | issue = 5| pages = 889–896 | doi = 10.1016/S0092-8674(94)90682-3 | pmid = 8087855 }}
* {{cite journal | last1 = Busby | first1 = S. | last2 = Ebright | first2 = R. | year = 1994 | title = Promoter structure, promoter recognition, and transcription activation in prokaryotes | url = | journal = Cell | volume = 79 | issue = 5| pages = 743–746 | doi = 10.1016/0092-8674(94)90063-9 | pmid = 8001112 }}
* {{cite journal | last1 = Pendergrast | first1 = P. S. | last2 = Ebright | first2 = Y. | last3 = Ebright | first3 = R. | year = 1994 | title = High-specificity DNA cleavage agent: design and application to kilobase and megabase DNA substrates | url = | journal = Science | volume = 265 | issue = 5174| pages = 959–961 | doi = 10.1126/science.8052855 | pmid=8052855}}
* {{cite journal | last1 = Niu | first1 = W. | last2 = Kim | first2 = Y. | last3 = Tau | first3 = G. | last4 = Heyduk | first4 = T. | last5 = Ebright | first5 = R. | year = 1996 | title = Transcription activation at Class II CAP-dependent promoters: two interactions between CAP and RNA polymerase | url = | journal = Cell | volume = 87 | issue = 6| pages = 1123–1134 | doi = 10.1016/S0092-8674(00)81806-1 | pmid = 8978616 | pmc = 4430116 }}
* {{cite journal | last1 = Miller | first1 = A. | last2 = Wood | first2 = D. | last3 = Ebright | first3 = R. | last4 = Rothman-Denes | first4 = L. |authorlink4=Lucia B. Rothman-Denes | year = 1997 | title = RNA polymerase β': a target for DNA-binding-independent activation | url = | journal = Science | volume = 275 | issue = 5306| pages = 1655–1657 | doi = 10.1126/science.275.5306.1655 | pmid = 9054361 }}
* {{cite journal | last1 = Kim | first1 = T.-K. | last2 = Ebright | first2 = R. | last3 = Reinberg | first3 = D. | year = 2000 | title = Mechanism of ATP-dependent promoter melting by transcription factor IIH | url = | journal = Science | volume = 288 | issue = 5470| pages = 1418–1421 | doi = 10.1126/science.288.5470.1418 | pmid=10827951}}
* {{cite journal | last1 = Naryshkin | first1 = N. | last2 = Revyakin | first2 = A. | last3 = Kim | first3 = Y. | last4 = Mekler | first4 = V. | last5 = Ebright | first5 = R. | year = 2000 | title = Structural organization of the RNA polymerase-promoter open complex | url = | journal = Cell | volume = 101 | issue = 6| pages = 601–611 | doi = 10.1016/S0092-8674(00)80872-7 | pmid = 10892647}}
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* {{cite journal | last1 = Goldman | first1 = S. | last2 = Ebright | first2 = R. | last3 = Nickels | first3 = B. | year = 2009 | title = Direct detection of abortive RNA transcripts ''in vivo'' | url = | journal = Science | volume = 324 | issue = 5929| pages = 927–928 | doi = 10.1126/science.1169237 | pmid = 19443781 | pmc = 2718712 }}
* {{cite journal | last1 = Chakraborty | first1 = A. | last2 = Wang | first2 = D. | last3 = Ebright | first3 = Y. | last4 = Korlann | first4 = Y. | last5 = Kortkhonjia | first5 = E. | last6 = Kim | first6 = T. | last7 = Chowdhury | first7 = S. | last8 = Wigneshweraraj | first8 = S. | last9 = Irschik | first9 = H. | last10 = Jansen | first10 = R. | last11 = Nixon | first11 = B.T. | last12 = Knight | first12 = J. | last13 = Weiss | first13 = S. | last14 = Ebright | first14 = R. | year = 2012 | title = Opening and closing of the bacterial RNA polymerase clamp | url = | journal = Science | volume = 337 | issue = 6094| pages = 591–595 | doi = 10.1126/science.1218716 | pmid = 22859489 | pmc = 3626110 }}
* {{cite journal | last1 = Zhang | first1 = Y. | last2 = Feng | first2 = Y. | last3 = Chatterjee | first3 = S. | last4 = Tuske | first4 = S. | last5 = Ho | first5 = M. | last6 = Arnold | first6 = E. | last7 = Ebright | first7 = R. | year = 2012 | title = Structural basis of transcription initiation | url = | journal = Science | volume = 338 | issue = 6110| pages = 1076–1080 | doi = 10.1126/science.1227786 | pmid = 23086998 | pmc = 3593053 }}
* {{cite journal | last1 = Zhang | first1 = Y. | last2 = Degen | first2 = D. | last3 = Ho | first3 = M. | last4 = Sineva | first4 = E. | last5 = Ebright | first5 = K. | last6 = Ebright | first6 = Y. | last7 = Mekler | first7 = V. | last8 = Vahedian-Movahed | first8 = H. | last9 = Feng | first9 = Y. | last10 = Yin | first10 = R. | last11 = Tuske | first11 = S | last12 = Irschik | first12 = H.| last13 = Jansen | first13 = R. | last14 = Maffioli | first14 = S. | last15 = Donadio | first15 = S. | last16 = Arnold | first16 = E. | last17 = Ebright | first17 = R. | year = 2014 | title = GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides | url = | journal = eLife | volume = 3 | pages = e02450 | doi = 10.7554/eLife.02450 | pmid = 24755292 | pmc = 3994528 }}
* {{cite journal | last1 = Degen | first1= D. | last2 = Feng | first2 = Y. | last3 = Zhang | first3 = Y. | last4 = Ebright | first4 = K. | last5 = Ebright | first5 = Y. | last6 = Gigliotti | first6 = M. | last7 = Vahedian-Movahed | first7 = H. |last8 = Mandal | first8 = S. | last9 = Talaue | first9 = M. | last10 = Connell | first10 = N. | last11 = Arnold | first11 = E. | last12 = Fenical | first12 = W. | last13 = Ebright | first13 = R. |year = 2014 | title = Transcription inhibition by the depsipeptide antibiotic salinamide A | journal = eLife | volume = 3 | pages = e02451 | doi = 10.7554/eLife.02451 | pmid = 24843001 | pmc = 4029172 }}
* {{cite journal | last1=Vvedenskaya | first1=I.| last2=Vahedian-Movahed| first2=H.| last3=Bird| first3=J.| last4=Knoblauch| first4=J.| last5=Goldman| first5=S.| last6=Zhang| first6=Y.| last7=Ebright| first7=R.| last8=Nickels| first8=B.| year=2014| title=Interactions between RNA polymerase and the "core recognition element" counteract pausing| journal=Science| volume=344| pages=1285–1289| doi=10.1126/science.1253458| pmid=24926020 | pmc=4277259}}
* {{cite journal | last1=Winkelman| first1=J.| last2=Vvedenskaya| first2=I.| last3=Zhang| first3=Y.| last4=Bird| first4=J.| last5=Taylor| first5=D.| last6=Gourse| first6=R.| last7=Ebright| first7=R.| last8=Nickels| first8=B.| year=2016| title=Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection| journal=Science| volume=351| issue=6277 | pages=1090–1093| doi=10.1126/science.aad6881 | pmid=26941320 | pmc=4797950}}
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* {{cite journal |author1=Lin, W. |author2=Das, K. |author3=Degen, D. |author4=Mazumder, A. |author5=Duchi, D. |author6=Wang, D. |author7=Ebright, Y. |author8=Ebright, R.Y. |author9=Sineva, E. |author10=Gigliotti, M. |author11=Srivastava, A. |author12=Mandal, S. |author13=Jiang, Y. |author14=Liu, Y. |author15=Yin, R. |author16=Zhang, Z. |author17=Eng, E. |author18=Thomas, D. |author19=Donadio, S. |author20=Zhang, H. |author21=Zhang, C. |author22=Kapanidis, A. |author23=Ebright, R. H. |lastauthoramp=yes |year=2018 |title=Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3) |journal=Mol. Cell |volume=70 |issue=1 |pages=60–71 |doi=10.1016/j.molcel.2018.02.026 |pmid=29606590|pmc=6205224 }}
* {{cite journal |author1=Vvedenskaya, I. |author2=Bird, J. |author3=Zhang, Y. |author4=Zhang, Y. |author5=Jiao, X. |author6=Barvík, I. |author7=Krásný, L. |author8=Kiledjian, M. |author9=Taylor, D. |author10=Ebright. R.H. |author11=Nickels, B. |lastauthoramp=yes |year=2018 |title=CapZyme-Seq comprehensively defines promoter-sequence determinants for RNA 5' capping with NAD |journal=Mol. Cell |volume=70 |issue=3 |pages=553–564 |doi=10.1016/j.molcel.2018.03.014 |pmid =29681497 |pmc=5935523}}
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*{{cite journal |author1=Li, L. |author2=Molodtsov, V |author3=Lin, W.|author4=Ebright, R. H. |author5=Zhang, Y. |lastauthoramp=yes |year=2020 |title=RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription |journal=Proc. Natl. Acad. Sci. USA |volume=117 }pages=5801-5809 |doi=10.1073/pnas.1920747117 |pmid=32127479 |pmc=7084136 }}

*{{cite journal |author1=Mazumder, A. |author2=Lin, M. |author3=Kapanidis, A.|author4=Ebright, R. H. |lastauthoramp=yes |year=2020 |title=Closing and opening of the RNA polymerase trigger loop |journal=Proc. Natl. Acad. Sci. USA |doi= 10.1073/pnas.1920427117 |pmid=32571927 |pmc=7355006 }}

*{{cite journal |author1=Winkelman, J. |author2=Pukhrambam, C. |author3=Vvedenskaya, I. |author4=Zhang, Y. |author5=Taylor, D. |author6=Shah, P. |author7=Ebright, R. H. |author8=Nickels, B. |lastauthoramp=yes |year=2020 |title=XACT-Seq comprehensively defines the promoter-position and promoter-sequence determinants for initial-transcription pausing |journal=Mol. Cell |doi=10.1016/j.molcel.2020.07.006 |pmid=32750314 }}

*{{cite journal |author1=Wang, C. |author2=Molodtsov, V. |author3=Firlar, E. |author4=Kaelber, J. |author5=Blaha, G. |author6=Su, M. |author7=Ebright, R. H. |lastauthoramp=yes |year=2020 |title=Structural basis of transcription-translation coupling |journal=Science |doi=10.1126/science.abb5317 |pmid=32820061 }}


== References == == References ==

Revision as of 20:41, 21 August 2020

American molecular biologist
Richard H. Ebright
Born (1959-06-11) June 11, 1959 (age 65)
NationalityAmerican
CitizenshipAmerican
Alma mater
Scientific career
FieldsBiology, Molecular Biology
Institutions

Richard H. Ebright is an American molecular biologist. He is the Board of Governors Professor of Chemistry and Chemical Biology at Rutgers University and Laboratory Director at the Waksman Institute of Microbiology.

Early life and education

Richard H. Ebright was born on 11 June 1959 to Richard J. Ebright and Jacqueline K. Ebright.

Ebright received an A.B. summa cum laude in biology from Harvard University in 1981 and a Ph.D. in Microbiology and Molecular Genetics from Harvard University in 1987. He was a Junior Fellow of the Harvard Society of Fellows from 1984 to 1987.

Career

Ebright was appointed as a faculty member in the Department of Chemistry at Rutgers University and as a Laboratory Director at the Waksman Institute of Microbiology in 1987. He was co-appointed as an Investigator of the Howard Hughes Medical Institute from 1997 to 2013.

Ebright has performed research on protein-DNA interaction, transcription initiation, transcription activation, transcription-translation coupling, and antibacterial drug discovery. Ebright's research results include the experimental demonstration that amino-acid-base contacts mediate DNA sequence recognition in protein–DNA interaction, the determination of the three-dimensional structural organization of the transcription initiation complex; the demonstration that initial transcription involves a "DNA scrunching" mechanism; the demonstration that transcription activation can proceed by a "recruitment" mechanism; the demonstration that bacterial transcription-translation coupling involves direct physical bridging of RNA polymerase and a ribosome by NusA and NusG; and the identification of novel antibacterial drug targets in bacterial RNA polymerase.

In 1994 Ebright was awarded the American Society of Biochemistry and Molecular Biology Schering-Plough Award for his research on transcription activation. In 1995 he received the Academic Press Walter J. Johnson Prize. In 2013 he received a National Institutes of Health MERIT Award. He was elected as a Fellow of the American Academy of Microbiology in 1996, the American Association for the Advancement of Science in 2004, the Infectious Diseases Society of America in 2011, and the American Academy of Arts and Sciences in 2016.

Ebright has opposed the proliferation of laboratories working on biological weapons agents and has supported the strengthening of biosafety and biosecurity measures to reduce risks of release of biological weapons.

Notable publications

  • Ebright, R.; Cossart, P.; Gicquel-Sanzey, B.; Beckwith, J. (1984). "Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli". Nature. 311 (5983): 232–235. doi:10.1038/311232a0. PMID 6090927.
  • Blatter, E.; Ebright, Y.; Ebright, R. (1992). "Identification of an amino acid-base contact in the GCN4-DNA complex by bromouracil-mediated photocrosslinking". Nature. 359 (6396): 650–652. doi:10.1038/359650a0. PMID 1406998.
  • Heyduk, T.; Lee, J.; Ebright, Y.; Blatter, E.; Zhou, Y.; Ebright, R. (1993). "CAP interacts with RNA polymerase in solution in the absence of promoter DNA". Nature. 364 (6437): 548–549. doi:10.1038/364548a0. PMID 8393148.
  • Zhou, Y.; Busby, S.; Ebright, R. (1993). "Identification of the functional subunit of a dimeric transcription activator protein by use of "oriented heterodimers". Cell. 73 (2): 375–379. doi:10.1016/0092-8674(93)90236-J. PMID 8477449.
  • Chen, Y.; Ebright, Y.; Ebright, R. (1994). "Identification of the target of a transcription activator protein by protein-protein photocrosslinking". Science. 265 (5168): 90–92. doi:10.1126/science.8016656. PMID 8016656.
  • Blatter, E.; Ross, W.; Tang, H.; Gourse, R.; Ebright, R. (1994). "Domain organization of RNA polymerase α subunit: C-terminal 85 amino acids constitute a domain capable of dimerization and DNA binding". Cell. 78 (5): 889–896. doi:10.1016/S0092-8674(94)90682-3. PMID 8087855.
  • Pendergrast, P. S.; Ebright, Y.; Ebright, R. (1994). "High-specificity DNA cleavage agent: design and application to kilobase and megabase DNA substrates". Science. 265 (5174): 959–961. doi:10.1126/science.8052855. PMID 8052855.
  • Mukhopadhyay, J.; Kapanidis, A.; Mekler, V.; Kortkhonjia, E.; Ebright, Y.; Ebright, R. (2001). "Translocation of σ70 with RNA polymerase during transcription: fluorescence resonance energy transfer assay for movement relative to DNA". Cell. 106 (4): 453–463. doi:10.1016/S0092-8674(01)00464-0. PMID 11525731.
  • Mekler, V.; Kortkhonjia, E.; Mukhopadhyay, J.; Knight, J.; Revyakin, A.; Kapanidis, A.; Niu, W.; Ebright, Y.; Levy, R.; Ebright, R. (2002). "Structural organization of bacterial RNA polymerase holoenzyme and the RNA polymerase-promoter open complex". Cell. 108 (5): 599–614. doi:10.1016/S0092-8674(02)00667-0. PMID 11893332.
  • Benoff, B.; Yang, H.; Lawson, C.; Parkinson, G.; Liu, J.; Blatter, E.; Ebright, Y.; Berman, H.; Ebright, R. (2002). "Structural basis of transcription activation: the CAP-αCTD-DNA complex". Science. 297 (5586): 1562–1566. doi:10.1126/science.1076376. PMID 12202833.
  • Winkelman, J.; Pukhrambam, C.; Vvedenskaya, I.; Zhang, Y.; Taylor, D.; Shah, P.; Ebright, R. H.; Nickels, B. (2020). "XACT-Seq comprehensively defines the promoter-position and promoter-sequence determinants for initial-transcription pausing". Mol. Cell. doi:10.1016/j.molcel.2020.07.006. PMID 32750314. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
  • Wang, C.; Molodtsov, V.; Firlar, E.; Kaelber, J.; Blaha, G.; Su, M.; Ebright, R. H. (2020). "Structural basis of transcription-translation coupling". Science. doi:10.1126/science.abb5317. PMID 32820061. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)

References

  1. ^ "Dr. Richard H. Ebright". Waksman Institute, Rutgers University. Retrieved October 6, 2011.
  2. ^ "Ebright, Richard H." Department of Chemistry, Rutgers University. Retrieved August 21, 2020.
  3. ^ Ebright, R. H.; Cossart, P.; Gicquel-Sanzey, B.; Beckwith, J. (1984). "Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli". Nature. 311 (5983): 232–235. doi:10.1038/311232a0. PMID 6090927.
  4. ^ Zhang, Y.; Feng, Y.; Chatterjee, S.; Tuske, S.; Ho, M. X.; Arnold, E.; Ebright, R. H. (2012). "Structural Basis of Transcription Initiation". Science. 338 (6110): 1076–80. doi:10.1126/science.1227786. PMC 3593053. PMID 23086998.
  5. ^ Kapanidis, A. N.; Margeat, E.; Ho, S. O.; Kortkhonjia, E.; Weiss, S.; Ebright, R. H. (2006). "Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism". Science. 314: 1144–1147. doi:10.1126/science.1131399. PMC 2754788. PMID 17110578.
  6. ^ Revyakin, A.; Liu, C.; Ebright, R. H.; Strick, T. (2006). "Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching". Science. 314 (5802): 1139–1143. Bibcode:2006Sci...314.1139R. doi:10.1126/science.1131398. PMC 2754787. PMID 17110577.
  7. ^ Benoff, B.; Yang, H.; Lawson, C. L.; Parkinson, G.; Liu, J.; Blatter, E.; Ebright, Y. W.; Berman, H. M.; Arnold, E.; Ebright, R. H. (2002). "Structural basis of transcription activation: the CAP-alphaCTD-DNA complex". Science. 297 (5586): 1562–1566. Bibcode:2002Sci...297.1562B. doi:10.1126/science.1076376. PMID 12202833.
  8. ^ Feng, Y.; Zhang, Y.; Ebright, R. H. (2016). "Structural basis of transcription activation". Science. 352 (6291): 1330–1333. doi:10.1126/science.aaf4417. PMC 4905602. PMID 27284196.
  9. ^ Wang, C.; Molodtsov, V.; Firlar, E.; Kaelber, J.; Blaha, G.; Su, M.; Ebright, R. H. (2020). "Structural basis of transcription-translation coupling". Science. doi:10.1126/science.abb5317. PMID 32820061. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
  10. ^ Mukhopadhyay, J.; Das, K.; Ismail, S.; Koppstein, D.; Jang, M.; Hudson, B.; Sarafianos, S.; Tuske, S.; Patel, J.; Jansen, R.; Irschik, H.; Arnold, E.; Ebright, R. H. (2008). "The RNA polymerase "switch region" is a target for inhibitors". Cell. 135 (2): 295–307. doi:10.1016/j.cell.2008.09.033. PMC 2580802. PMID 18957204. {{cite journal}}: Unknown parameter |lastauthoramp= ignored (|name-list-style= suggested) (help)
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