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Good Evidence for Antineoplaston Efficacy from Japan

A 2015 study from Ogata et al. titled "Randomized Phase II Study of 5-Fluorouracil Hepatic Arterial Infusion with or without Antineoplastons as an Adjuvant Therapy after Hepatectomy for Liver Metastases from Colorectal Cancer" (https://doi.org/10.1371/journal.pone.0120064) records that in an open label, non-blinded but randomized phase II study cancer specific survival rate (CSS) was significantly higher in the antineoplaston arm vs. the control (i.e. non-antineoplaston) arm. This study had 65 patients enrolled, with 33 of those in the control group not receiving antineoplaston therapy, and 32 receiving the treatment. Median survival in the antineoplaston group, was, in fact, 67 months vs. 39 months, with a CSS of 60% and 32%, respectively. Furthermore, there were no incidental serious toxicities or apparent liver or kidney damage. Now, I demand an answer on moral grounds: Why is this study not mentioned in this article? I hold a biochemistry degree and a master's degree in medical science and would like to know why this isn't mentioned in the article.

Additionally, Ushijima et al. in the journal Oncology Reports published an article called "Demethylation effect of the antineoplaston AS2-1 on genes in colon cancer cells" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868501/) which clearly reports epigenetic changes in colon cancer cells, changes which are very likely to suppress cancer development and progression using the body's natural tumor suppression system. This work from these researchers is highly suggestive, just as Dr. Burzynski has stated in on-the-record interviews, that epigenetic modulations in response to the presence of antineoplastons are, in whole or in part, how they fight cancer.

While this is not absolute proof of antineoplaston therapy's efficacy, it is extremely favorable evidence and analysis, and I would just like to know how anybody could look at these studies and act as if the whole antineoplaston therapy question should just be dismissed as quackery.

Misplaced Pages - in fact, anybody - I ask you: why is none of this mentioned in the article on the topic? In fact, why are the staff at Misplaced Pages not seriously disturbed at the lack of research into this topic? How could anybody look at these studies and not demand further investigation? 2600:1700:407B:2810:153:D9CA:A5FC:2ECC (talk) 03:09, 22 January 2023 (UTC)

Read WP:MEDRS and WP:PRIMARY. We wait until there are favorable secondary sources that collect primary ones. That is also how competent scientists judge those things. Accepting primary studies at face value is naive and amateurish. --Hob Gadling (talk) 06:49, 22 January 2023 (UTC)

I appreciate your reply.

1. Who said anybody should "just accept" this or that study "at face value"? - nobody, that's who. The point I made is that this is an example of a professional, independent, peer-reviewed clinical trial which produced results that unambiguously suggest that antineoplastons have clinical efficacy. Yes - duh, obviously - it could be a fluke - it's just that, without evidence to the contrary it is unlikely to be a fluke. Does such evidence exist, or not? No clinician in their right mind would say that "this single study means we need to start giving patients antineoplastons right away!" ...but no objective clinician could possibly look at that study and honestly say that this doesn't warrant interest. Given the history of the field any physician or researcher would be PERFECTLY within their rights to look at that study and say "meh, I'll bet it's a fluke - happens all the time," but that sort of reply is not science. Only follow-up studies that demonstrate no replication of effect WOULD be evidence. A study like that warrants follow up, and that's a plain fact. To ignore it wholesale in an article which is designed precisely to deal with the very controversy of the efficacy of the drugs is NOT objective or neutral.

2. Misplaced Pages's own policy (the one you linked me to) on Primary Sources (from "Reliable sources") states:

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"A primary source may be used on Misplaced Pages only to make straightforward, descriptive statements of facts that can be verified by any educated person with access to the primary source but without further, specialized knowledge. For example, an article about a musician may cite discographies and track listings published by the record label, and an article about a novel may cite passages to describe the plot, but any interpretation needs a secondary source."

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And here :

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Primary sources should NOT normally be used as a basis for biomedical content. This is because primary biomedical literature is exploratory and often not reliable (any given primary source may be contradicted by another). Any text that relies on primary sources should usually have minimal weight, only describe conclusions made by the source, and describe these findings so clearly that any editor can check the sourcing without the need for specialist knowledge. Primary sources should never be cited in support of a conclusion that is not clearly made by the authors

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Mentioning the results of the aforementioned 2015 Ogata et al. study clearly would not violate the explicit, stated policy, and in fact would do wonders for the objectivity of the article.

3. This article currently says verbatim that "there is no clinical evidence of the efficacy of these methods." The authors throughout the Wiki article were very careful to be objective and only report the opinions of institutes and bodies that stated that antineoplastons were not effective, instead of making categorical statements of fact or categorically characterizing the entire extent field of evidence as one way or the other. That is objectivity. However, in the aforementioned statement, this standard was dropped and the article makes a categorical statement which is, in fact, false, because the 2015 Ogata et al. study is an exact contradiction to the statement.

4. I have no serious academic interest, economic incentive or personal conflict on this matter at all. I just care about objectivity and have an interest in healthcare. Surely you're a clinician or scientist of some kind (I would hope) - what exactly IS your view on the 2015 Ogata et al. study? Do you think it was a fluke?

I apologize for the length of my reply. 2600:1700:407B:2810:6015:D9D0:4A7D:D0AE (talk) 16:05, 22 January 2023 (UTC)

I have an idea of Hobs opinion, but instead I'm going to give you mine. For us encyclopedia editors, Ogata et al is entirely unimportant, because of WP:RS and WP:MEDRS. - Roxy the dog 16:21, 22 January 2023 (UTC)

Uncannily accurate. --Hob Gadling (talk) 17:11, 22 January 2023 (UTC)

Agree. Guy (help! - typo?) 22:13, 24 January 2023 (UTC)

Let me explain. When summarising the 2015 Japanese study, you quoted raw survival data. This means that you've disregarded the existence of confounders and, essentially, the entire statistical model. However, the study conclusion reads: "Overall survival was not statistically improved (p=0.105) in the AN arm (n=32). RFS was not significant (p=0.343)." As you may know, the p-value indicates, in lay terms, to what extent the observed outcome can be credited to the studied intervention. Commonly, statistical models require p not to exceed 0.05 for the results to be considered statistically significant.

Here in this study, p was significantly higher, which essentially means that the observed outcome (e.g., difference in survival) has not been solely due to the intervention (antineoplaston therapy), since other factors have influenced it more strongly.

To but it bluntly, the study offers some evidence that antineoplastons are not effective in the studied dose for this type of cancer (although, being an open-label study, its evidence value is anyway low).

If you insist on including the paper, I'm ok with summarising it along the lines: In a 2015 randomised open-label study carried out in Japan, 5-fluorouracil was ineffective as an adjuvant therapy for liver metastasis resulting from colorectal cancer. — kashmīrī  17:09, 22 January 2023 (UTC)

Your analysis is excellent, and we should definitely not include it for those reasons. Guy (help! - typo?) 22:15, 24 January 2023 (UTC)

JzG, did you read the article before proclaiming Kashmirir's analysis excellent? RudolfoMD (talk) 04:31, 17 January 2024 (UTC)

Yes. My personal view: Primary sources with "antineoplastons" as an adjuvant therapy for liver cancer were, and remain, irrelevant to the inflated and entirely unsupportable claims by Burzynski for use of his quackery as a magical primary therapy (in the words of his stans, a cure) for incurable brain cancers, based on nearly half a century of utterly underwhelming results and large numbers of (well documented) dead patients bilked out of vast sums of money.

My Misplaced Pages policy view: Misplaced Pages is not here to blaze the trail in promoting commercial claims where the consensus in the relavant professional community is that tsaid claims are at best nonsense, and at worst entirely fraudulent.

When all the reliable secondary sources show he's a mendacious quack, so do we. Guy (help! - typo?) 19:24, 17 January 2024 (UTC)

It was a simple yes/no question - the 2015 Japanese study - did you read it before proclaiming Kashmirir's analysis excellent or not. Yes, you say. I believe you know what a primary endpoint is, and you know that the study that you read met its primary endpoint. And yet you insist an analysis is excellent that misrepresented that primary endpoint (p=0.037 for CSS) as not statistically significant. That is not excellent analysis. It seems to me your preconceptions are clouding your judgement. That's the most charitable interpretation of the facts in front of me I can come up with. How do you explain it? I expected the science and data to show Burzynski's work to be without much merit. But what I'm finding so far is multiple extremely flawed criticisms based on falsehoods. One of which has already been acknowledged and fixed. RudolfoMD (talk) 02:10, 18 January 2024 (UTC)

1. I'm sorry but did you not read the rest of the findings section you quoted from??! It's not even five or six sentences long! And the very next sentence directly after the one you quoted states:

Nevertheless, the CSS rate was significantly higher in the AN arm versus the control arm (n=33) with a median survival time 67 months (95%CI 43-not calculated) versus 39 months (95%CI 28-47) (p=0.037) and 5 year CSS rate 60% versus 32% respectively.

At the risk of being redundant, I will point out that the P-value is below the threshold of 0.05 you selected! Not that p = 0.05 is some "special" threshold - it's just a convention. Many researchers value a p of 0.1, some 0.05, some 0.01 - those are all not uncommon p values. Either way it doesn't matter since you chose the p of 0.05, which you must not have realized the study conclusion did in fact satisfy. Did you not read the paltry few sentences of the article summary? Or are you seriously purposefully distorting the information? (See #3 below)

2. The Misplaced Pages policy states: "Any text that relies on primary sources should...only describe conclusions made by the source ... Primary sources should never be cited in support of a conclusion that is not clearly made by the authors

Now, your suggested "summary" is a complete reversal of the conclusion the study authors reach, which is described in the single sentence - not difficult to read or see - in the "Interpretations" paragraph of the study: Antineoplastons (A10 Injection and AS2-1) might be useful as adjunctive therapy in addition to HAI after hepatectomy in colorectal metastases to the liver. To include YOUR summary of the article would be a direct violation of the Misplaced Pages guideline you originally invoked!

3. Perhaps most telling of all, you either didn't read the paltry few sentences of the article summary, or had more insidious designs. I'm really just quite perplexed.

(A) Your "explanation" - which this person "Guy" bizarrely praised as "excellent" - suggested that a summary of the article could be included as In a 2015 randomised open-label study carried out in Japan, 5-fluorouracil was ineffective as an adjuvant therapy for liver metastasis resulting from colorectal cancer.

Excuse me, but what...the hell? The study was not testing 5-fluorouracil! It was not the adjuvant! You obviously didn't understand the simple trial! The article was testing addition of antineoplastons TO a therapeutic HAI (Hepatic Arterial Infusion) of 5-fluorouracil - the 5-fluorouracil is not an antineoplaston and is a known chemotherapeutic for this adminstration route - which is WHY they were using it in the first place! The antineoplastons were being added as adjuvants to be tested - BOTH groups got 5-fluoruracil, ONE got the antineoplastons.

(B) You obviously didn't understand the study despite it being incredibly simple. You didn't understand what was being tested, didn't know that 5-fluorouracil was not an antineoplaston, didn't know that 5-fluorouracil via HAI was a known chemotherapeutic, and thought that the data suggested 5-fluorouracil was ineffective, when in fact it is KNOWN to be effective, and the data in fact suggested that the antineoplaston WAS effective. I mean, this is just a ridiculous misinterpretation (or something) on your part - I'm sorry.

4. While your characterization of a study on basic research as "utterly useless" regarding clinical applications is an absurd exaggeration, it's perfectly legitimate to suggest it doesn't belong in a subsection, perhaps, about clinical results of a trial of the drug. But to call such basic research "utterly useless" is mind-numbingly obtuse - you can't GET to clinical trials without some plausible mechanism or evidence buttressed by basic research. I have no problem not mentioning the known epigenetic activity of antineoplastons in a summary of clinical trials - but to say it just shouldn't be included anywhere in an article about Burzynski and his therapy on antineoplastons is asinine. It's a known effect of the drug in cancerous cell lines and you have huge portions of an article dedicated to - supposedly - objectively analyzing the efficacy, plausibility and suitability of Burzynski's therapy for cancer treatments! To dismiss it as "utterly useless" is absurd!

5. I apologize for any overtly rude-sounding aggression but I was just left gobsmacked and dumbfounded by your response. I thought the people who would be editing a Misplaced Pages article about a supposed quack cancer treatment would be highly qualified experts in a closely related field, if not in the field itself. Instead it seems as if you weren't even familiar with a common chemotherapeutic agent, didn't know what kind of medication it was, and were unable to understand a simple article.

6. Let me be clear: I have no intention to continuously revisit these posts over and over again, though perhaps I might if I must. I feel I have said enough that needs to be said and the record will show it here. As I said before I have NO serious dog in this fight or conflict of interest, and I even am SUSPICIOUS of Burzynski's therapy myself! 40+ years of antineoplaston existence - you would think - WOULD render something more substantial by now if the therapy is legitimate. In addition, I'm fully aware that Burzynski has registered numerous trials - even many dozens which he suspiciously hasn't published the results of - and in the long run you're bound to get flukes. This study could have been a fluke - BUT THE EVIDENCE does NOT suggest that! To fail to mention this study in the kind of article you've written is simply NOT objective analysis and below the kind of objectivity I would expect from Misplaced Pages, which I have donated to more than once in the past and find an invaluable source of information. The fact is sharing these kinds of controlled trial results CANNOT damage humanity - it will all be part of a record that people are entitled to know about, and to FAIL to mention it is just as bad as promoting false information.

Again I'm sorry if this sounded rude but direct confrontation of distortion and confusion can often sound rude when its sole purpose is to get closer to accurate representation of the truth. I really hope you consider this further regardless of whatever decision you make and appreciate your time. I'm sorry again for the length of my writing here but I know of no other way to be thorough and as I said before I hope I do not find myself coming back to this repeatedly since I believe the analysis is self-evident and virtually all that I needed to say has been said here, though it be lengthy. 2600:1700:407B:2810:D80F:D35D:F99E:FBCA (talk) 04:45, 27 January 2023 (UTC)

See the second sentence of this reply to you. - Roxy the dog 05:48, 27 January 2023 (UTC)

many dozens which he suspiciously hasn't published the results of
— User:2600:1700:407B:2810:D80F:D35D:F99E:FBCA 04:45, 27 January 2023 (UTC)

Check these recent edits of mine. Burzynski has published a lot more results than the article lets on. Bon courage insisted on stonewalling when I tried to work with them to correct the false/outdated claim in the article that "that researchers other than Burzynski and his associates have not been successful in duplicating his results". (Though just before finishing this comment, I saw some further edits have been made - hope they are a pleasant surprise.) RudolfoMD (talk) 04:42, 17 January 2024 (UTC)

Re. the Ogata study, it's all basic research – utterly useless for an article about clinical applications. We don't even need to go into the primary vs secondary debate. — kashmīrī  17:17, 22 January 2023 (UTC)

You grossly misrepresented the findings, ignoring the primary endpoint.

If you insist on including the paper, I'm ok with summarising it along the lines: In a 2015 randomised open-label study carried out in Japan, 5-fluorouracil was ineffective as an adjuvant therapy for liver metastasis resulting from colorectal cancer.
— User:Kashmiri 17:09, 22 January 2023 (UTC)

That's a deceptive summary. You misrepresented the primary endpoint (p=0.037 for CSS) as not statistically significant when it was. You don't want to walk it back, fine. But I'm getting a lot of pushback when I'm removing demonstrably false, defamatory information violating BLP that I stumbled upon. RudolfoMD (talk) 04:21, 18 January 2024 (UTC)

As other editors have observed, PMID:25790229 is an poor/unreliable source, and simply not usable here. Bon courage (talk) 07:46, 18 January 2024 (UTC)

The Findings section contained

1. "Overall survival"- not significant
2. "RFS" - not significant
3. "CSS rate" - barely significant at 3.7%
4. "Cancer recurred" - no statement about significance.

So, we have the Multiple comparisons problem - there are four outcomes, one of which is barely significant. Because of multiple comparisons, the significances need to be adapted, making the third one not significant either. But the most relevant finding is obviously the first one, overall survival. (Hint: If the treatment tends to kill the patient as well as the cancer, that is not helpful.) That is the one Kashmiri talked about, and there is nothing wrong with that. Can you please stop trying to cram cherry-picked results into the article? --Hob Gadling (talk) 08:01, 18 January 2024 (UTC)

Diffs showing cherry-picked results being crammed into the article? I can't stop doing what I haven't started. Back off with the personal attack, eh? The problem is I'm getting a lot of pushback when I'm removing demonstrably false, defamatory information violating BLP that I stumbled upon. Does MEDRS say anything about the Multiple comparisons problem? Perhaps it should. But, does V? No. When it comes to BLP violations, wp:V is what matters. That makes it usable here, even though it's a single study. I notice no one is pushing back on this central point. But more importantly, true or false: Cancer Specific Survival was the SOLE, PRE-selected, primary endpoint, and it DOUBLED.
True. Kind of blows apart your whole argument. Kashmiri grossly misrepresented the sole, primary endpoint (p=0.037 for CSS) as not statistically significant when it was. Y'all are defending that. And then K called it basic research - huh? Clinical studies are basic research now? Regarding 3: From the article:

Nevertheless, the CSS rate was significantly higher in the AN arm versus the control arm (n=33) with a median survival time 67 months (95%CI 43-not calculated) versus 39 months (95%CI 28-47) (p=0.037) and 5 year CSS rate 60% versus 32% respectively.

so why do you say 3.7%? "3.7" doesn't even appear in the paper! FR! BTW, the bulk of the shit-ton of negative info about neoplastons in the article is sourced only to non-MEDRS-compliant sources. If I was keen to make neoplastons look better, I could cut most of the negative info out of the article based on MEDRS. How 'bout we compromise, leave all that in, and take out the false info I'm objecting to? RudolfoMD (talk) 08:38, 18 January 2024 (UTC)

Diffs showing cherry-picked results being crammed into the article? Aren't you trying to put what you call "Good Evidence for Antineoplaston Efficacy from Japan" into the article? It is one primary study out of many, so it is cherry-picking. Even if we regard only this study, you are cherry-picking the one significant result out of four.

Back off with the personal attack, eh? A "personal attack" is something that refers to the person instead of what the person is saying or doing. I referred to what you were saying or doing. That is not a personal attack.

Does MEDRS say anything about the Multiple comparisons problem MEDRS does not explicitly mention it, but considering it is part of good practice. If you avoid primary studies like this one, that is a good start avoiding the multiple comparisons problem.

Cancer Specific Survival was the SOLE, PRE-selected, primary endpoint Was the "PRE-selected, primary endpoint" published before the result was? I cannot find it.

why do you say 3.7%? 3.7% = 0.037.

the bulk of the shit-ton of negative info about neoplastons in the article is sourced only to non-MEDRS-compliant sources WP:PARITY say, In an article on a fringe topic, if a notable fringe theory is primarily described by amateurs and self-published texts, verifiable and reliable criticism of the fringe theory need not be published in a peer-reviewed journal. --Hob Gadling (talk) 10:18, 18 January 2024 (UTC)

You can't even find a diff showing I called anything "Good Evidence for Antineoplaston Efficacy from Japan," Hob. Or that I tried to put the article you are trying to refer to into the article. So...Your Can you please stop trying to cram cherry-picked results into the article? when I had done nothing of the sort = false and disparaging but OK, a "not personal" attack, so you're sort of right. RudolfoMD (talk) 13:32, 18 January 2024 (UTC)

"Good Evidence for Antineoplaston Efficacy from Japan" is the title of this thread. You are writing contributions to it, and I got the impression that you are supporting the IP that started the thread and trying to get that study cited by the article.

So you are not trying to get the Ogata study into the article? Then what are you trying to achieve here by talking about the study? This page is for discussing improvements to the article. It is not a forum. --Hob Gadling (talk) 15:49, 18 January 2024 (UTC)

You can't even find a diff showing Or that I tried to put the article you are trying to refer to into the article. So... - diff. MrOllie (talk) 18:27, 18 January 2024 (UTC)

BLP violation

Other investigators have been successful in duplicating some of his results. It's my understanding that BLP requires removing the false claim that "other investigators have not been successful in duplicating" any of his results. We all know: Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page, especially if potentially libellous. This is obviously poorly sourced as it is contradicted by w:V .gov sources. I've pulled it. If anyone want's to revert, I urge a visit to Misplaced Pages:Biographies_of_living_persons/Noticeboard as a next, pre-revert step. RudolfoMD (talk) 04:21, 18 January 2024 (UTC)

Classic WP:CRYBLP. Questions of experimental replication are not biographical; you just need a reliable source saying whether the replication has happened (or not). Bon courage (talk) 07:48, 18 January 2024 (UTC)

Oddly, I can't find an NIH publication.

A footnote in a journal article on the Phase III trial that the wipedia article uses as a source:

is

§ See M. R. Hammer, Burzynski antineoplaston case study: conflict issues and recommendations. Office of Alternative Medicine report, National Institutes of Health, 1996; M. Hammer, The management of dispute and judgment process in controversial complementary and alternative medicine research. Office of Alternative Medicine Report, National Institutes of Health, 1996.

Has anyone found a copy of it anywhere online? I can't with google.

The article is by Hammer and he is citing his own work ... which I can't find. Curious. Also, he doesn't put it in the References section endnote like all his other sources, but rather in a footnote. Also curious. The resulting procedures - methods of social management of research in controversial areas to allow them to proceed anyway that the reference documents haven't been employed in a subsequent second attempt. Curious as well. RudolfoMD (talk) 04:24, 17 January 2024 (UTC)

References

1. Hammer, Mitchell R.; Jonas, Wayne B. (March 2004). "Managing Social Conflict in Complementary and Alternative Medicine Research: The Case of Antineoplastons". Integrative Cancer Therapies. 3 (1): 59–65. doi:10.1177/1534735404263448. PMID 15035877.

WWayne Jonas should not be cited, he's a quackery apologist (e.g. author of a number of papers promoting the entirely refuted nonsense that is homeopathy). Guy (help! - typo?) 19:39, 17 January 2024 (UTC)

Huh? I am not looking for or seeking to cite "WWayne Jonas" <sic> work in the encyclopedia. And given your recent dubious evaluation of what is "excellent", I'm less interested in what you are sharing, un-prompted and citation-free. I'm looking for M. R. Hammer's 1996 NIH publication, not Hammer and Jonas' 2004 ICT publication, which is obviously readily available at the linked source I provided - <ref name=HammerICT>. Do you have anything helpful to offer about what I'm actually expressing curiosity? RudolfoMD (talk) 02:36, 18 January 2024 (UTC)

You kind've are. Wayne Jonas was director of the Office of Alternative Medicine at the time. The OAM (now the NCCIH) is independent from the rest of the NIH, so you probably won't find their reports in the same places as the rest of the NIH's output. It wouldn't be usable on Misplaced Pages anyway. MrOllie (talk) 02:52, 18 January 2024 (UTC)

Thanks for the info. Why wouldn't it be usable with subject matter where MEDRS doesn't apply? RudolfoMD (talk) 04:07, 18 January 2024 (UTC)

RudolfoMD, you wrote: "I am not looking for or citing "WWayne Jonas" <sic> work." Actually you are. Jonas is one of the authors of "Managing Social Conflict in Complementary and Alternative Medicine Research: The Case of Antineoplastons". Mitchell R. Hammer, PhD, and Wayne B. Jonas, MD

So Jonas is one of the authors, and, as noted above by Guy, he also happens to be a promotor of quack medicine. -- Valjean (talk) (PING me) 05:46, 18 January 2024 (UTC)

I would be amazed if you got consensus that a report from the OAM is RS even in non medical contexts, let alone for Burzynski-related stuff. The OAM was set up in the first place because Sen. Tom Harkin was a believer (specifically in antineoplastons and bee pollen therapy) and he set the office up and kept it funded to promote those treatments. The whole thing is a political exercise that has very little to do with science. MrOllie (talk) 18:33, 18 January 2024 (UTC)

- O'Brien RudolfoMD (talk) 07:20, 18 January 2024 (UTC)

Questionable WP:ABOUTSELF source

The source https://pubmed.ncbi.nlm.nih.gov/3527634/ should really not be used for anything like a factual claim, as it's ABOUTSELF material - Burzynski's own self-serving statement, with no objective review, and including contentious and likely tendentious claims like "The treatment was free from significant side-effects and resulted in objective response in a number of advanced cancer cases". After half a century, there should be an independent source for this, and almost certainly would be, if it were objectively true. Guy (help! - typo?) 19:38, 17 January 2024 (UTC)

Claim of copyright violation

The wording is a bit close, but it is a paraphrase. Rather than deleting it, suggest a reword. MrOllie (talk) 02:59, 18 January 2024 (UTC)

False. It's not a paraphrase. It's bloody verbatim copying by JzG contrary to a Misplaced Pages policy with legal considerations. WP:C / COPYRIGHT. RudolfoMD (talk) 04:13, 18 January 2024 (UTC)

It's called plagiarism. Putting it in quotes and attributing it solved the problem. -- Valjean (talk) (PING me) 07:17, 18 January 2024 (UTC)

Now it's more messed up. a cancer expert and an FDA official told Reuters and Reuters said aren't the same. RudolfoMD (talk) 04:40, 18 January 2024 (UTC)

Well, perhaps you should have left well alone, then, since your clumsy attempt to fix the “problem” of reality rejecting Burzynski’s piss therapy seems to be the root cause of all this drama. Guy (help! - typo?) 09:06, 22 January 2024 (UTC)

Talk page vandalism.

Beware Talk page vandalism removing active discussion. RudolfoMD (talk) 06:49, 18 January 2024 (UTC)

Now a third time. I was archiving old and inactive content and didn't notice you had left comments in some of them. Now you have restored the whole thing. I'll be more careful with the next try. -- Valjean (talk) (PING me) 07:07, 18 January 2024 (UTC)

To avoid this in the future, don't comment on such old threads. Start a new thread. -- Valjean (talk) (PING me) 07:14, 18 January 2024 (UTC)

Thank you! Such helpful advice. SO kind of you. RudolfoMD (talk) 07:21, 18 January 2024 (UTC)

Notice

{{BLP noticeboard}} RudolfoMD (talk) 09:05, 18 January 2024 (UTC)

Semi-protected edit request on 5 March 2024

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The article is slanderous. Reliable source : Burzynski documentary. Cancer cure cover up. It’s big business. He’s not a quack. Big $ has all the power to run smeer campaigns on anyone they like. The fda & Texas medical board were so despicable & unashamedly bold in taking him down because of his non invasive EFFECTIVE treatment of cancer. There are so many testimonials court appearances protests & news reports in this 2 part documentary it’s mind blowing. Deedssky (talk) 05:57, 5 March 2024 (UTC)<Eric Merola>

 Not done That documentary is not a reliable source. Far from it. Bon courage (talk) 06:01, 5 March 2024 (UTC)

Semi-protected edit request on 11 October 2024

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Under "Antineoplaston Therapy":

Since 2011, the clinic has marketed itself as offering "personalized gene-targeted cancer therapy", which has stirred further controversy. David Gorski argues that the concept of "personalised cancer therapy" is "more of a marketing term than a scientifically meaningful description". According to Gorski, a research oncologist, it appears unlikely that the Burzynski clinic would indeed be able to actually personalise gene-targeting therapies, i.e., "identify who would benefit from specific targeted therapies simply from blood tests," as Burzynski claims, since there are no proven methods to achieve this. Consequently, many reject Burzynski's claim of offering personalized medicine, because in reality his patients are administered untested combinations of various approved and unapproved medications, without a sound rationale for a given combination and without "any concern for potential adverse reactions".

I suggest removing this paragraph or reworking it entirely. Testing for genetic mutations is the premise of finding the appropriate therapy for many types of cancer. While Dr. Gorski may have a point regarding the semantics, and while his point is somewhat related to the Burzynski Clinic's claims of providing "personalized" services, a reader might draw the conclusion that genetic testing for cancer treatment does not exist. Ajordan538 (talk) 19:05, 11 October 2024 (UTC)

 Not done for now: please establish a consensus for this alteration before using the {{Edit semi-protected}} template. PianoDan (talk) 20:22, 18 October 2024 (UTC)

Help I just want to add another film name

I tried to edit this page to add in another film that was directed by Eric Merola with a release date of 2016. The name of the film is (Burzynski: Cancer Cure Cover Up). For some reason I ended up being posted in the M.R. Hammer talk. I know the subject matter is controversial, however the film I mentioned is clearly mentioned on the IMDb website and I just watched it on the Tubi streaming service. This film clearly exists. Thanks for any help in this matter Mrgrimfate (talk) 02:15, 31 December 2024 (UTC)

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