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{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 365890277
⚫ | Name = Polyethylene glycol
| ImageFile = Poly(ethylene glycol) alternate.svg
⚫ | ImageName = Polyethylene glycol
⚫ | IUPACName = Polyethylene glycol
⚫ |Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|correct|CAS}}
⚫ | CASNo = 25322-68-3

| UNII_Ref = {{fdacite|correct|FDA}}


| UNII = B697894SGQ
{{Chembox new
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
⚫ | Name = Polyethylene glycol
| ChemSpiderID = none
| ImageFile = PEG400.gif
⚫ | ImageName = Polyethylene glycol
⚫ | IUPACName = Polyethylene glycol
⚫ | Section1 = {{Chembox Identifiers
⚫ | CASNo = 25322-68-3
}} }}
| Section2 = {{Chembox Properties |Section2={{Chembox Properties
| Formula = C<sub>2n</sub>H<sub>4n+2</sub>O<sub>n+1</sub>, n = 8.2 to 9.1 | Formula = C<sub>2n</sub>H<sub>4n+2</sub>O<sub>n+1</sub>, n = 8.2 to 9.1
| MolarMass = 380-420 g/mol | MolarMass = 380-420 g/mol
| Density = 1.128 g/cm³ | Density = 1.128 g/cm<sup>3</sup>
| Viscosity = 90.0 cSt at 25 °C, 7.3 cSt at 99 °C | Viscosity = 90.0 cSt at 25 °C, 7.3 cSt at 99 °C
| MeltingPtC = 4 to 8
| MeltingPt = 4-8 °C
| MeltingPt_notes =
}} }}
| Section7 = {{Chembox Hazards |Section7={{Chembox Hazards
| FlashPt = 238 °C | FlashPtC = 238
| LD50 = 30 mL/kg, orally in rats | LD50 = 30 mL/kg, orally in rats
}} }}
}} }}


'''PEG 400''' (Polyethylene Glycol 400) is a low molecular weight grade of ]. It is a clear, colorless, viscous liqid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations. '''PEG 400''' (polyethylene glycol 400) is a low-molecular-weight grade of ]. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.


==Chemical properties==
==Additional Properties==
PEG 400 is strongly ]. The ] of polyethylene glycol 414 between hexane and water is 0.000015 (log<math>P = -4.8</math>), indicating that when polyethylene glycol 414 is mixed with water and hexane, there are only 1.5 parts of polyethylene glycol 414 in the hexane layer per 100,000 parts of polyethylene glycol 414 in the water layer.<ref>{{cite journal PEG 400 is strongly ]. The ] of PEG 400 between hexane and water is 0.000015 (log<math>P = -4.8</math>), indicating that when PEG 400 is mixed with water and hexane, there are only 15 parts of PEG400 in the hexane layer per 1 million parts of PEG 400 in the water layer.<ref>{{cite journal
| title= PEG 400, a hydrophilic molecular probe for measuring intestinal permeability | title = PEG 400, a hydrophilic molecular probe for measuring intestinal permeability
| author= T. Y. Ma, D. Hollander, P. Krugliak, K. Katz |author1=T. Y. Ma |author2=D. Hollander |author3=P. Krugliak |author4=K. Katz | journal = Gastroenterology
| volume = 98
| journal= Gastroenterology
| volume= 98 | issue = 1
| issue= 1 | pages = 39–46
| pages= 39-46 | year = 1990
⚫ |doi=10.1016/0016-5085(90)91288-h | url = http://www.gastrojournal.org/article/PII001650859091288H/abstract
| year= 1990
| pmid = 2293598}}</ref>
⚫ | url= http://www.gastrojournal.org/article/PII001650859091288H/abstract}}</ref>


PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, aromatic hydrocarbons and is slightly soluble in aliphatic hydrocarbons. PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons. It is not miscible with aliphatic hydrocarbons nor diethyl ether. Therefore, reaction products can be extracted from the reaction media with those solvents.


==References== ==References==

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Polyethylene glycol
Polyethylene glycol
Names
IUPAC name Polyethylene glycol
Identifiers
CAS Number
ChemSpider
  • none
UNII
Properties
Chemical formula C2nH4n+2On+1, n = 8.2 to 9.1
Molar mass 380-420 g/mol
Density 1.128 g/cm
Melting point 4 to 8 °C (39 to 46 °F; 277 to 281 K)
Viscosity 90.0 cSt at 25 °C, 7.3 cSt at 99 °C
Hazards
Flash point 238 °C (460 °F; 511 K)
Lethal dose or concentration (LD, LC):
LD50 (median dose) 30 mL/kg, orally in rats
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

PEG 400 (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.

Chemical properties

PEG 400 is strongly hydrophilic. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log P = − 4.8 {\displaystyle P=-4.8} ), indicating that when PEG 400 is mixed with water and hexane, there are only 15 parts of PEG400 in the hexane layer per 1 million parts of PEG 400 in the water layer.

PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons. It is not miscible with aliphatic hydrocarbons nor diethyl ether. Therefore, reaction products can be extracted from the reaction media with those solvents.

References

  1. T. Y. Ma; D. Hollander; P. Krugliak; K. Katz (1990). "PEG 400, a hydrophilic molecular probe for measuring intestinal permeability". Gastroenterology. 98 (1): 39–46. doi:10.1016/0016-5085(90)91288-h. PMID 2293598.
  • The Merck Index, 11th Edition
  • Handbook of Pharmaceutical Excipients
Category: