Iodophenpropit: Difference between revisions

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Revision as of 23:07, 1 March 2010 editحسن علي البط (talk \| contribs)Extended confirmed users, Pending changes reviewers19,940 editsm Removed category Organic iodides; Quick-adding category Organoiodides (using HotCat)← Previous edit		Latest revision as of 15:56, 7 September 2024 edit undoJWBE (talk \| contribs)Extended confirmed users10,127 edits removed Category:Iodobenzene derivatives; added Category:4-Iodophenyl compounds using HotCat
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	{{chembox		{{chembox
			\| Verifiedfields = changed
⚫	\|ImageFile=Iodophenpropit.~~png~~
			\| Watchedfields = changed
⚫	\|ImageSize=~~220px~~
			\| verifiedrevid = 400753856
⚫	\|IUPACName=3-(1''H''-imidazol-5-yl)propyl ''N'''-imidothiocarbamate
		⚫	\| ImageFile = Iodophenpropit.svg
⚫	\|OtherNames=1--N'-formamidine
		⚫	\| ImageSize = 240
⚫	\|Section1={{Chembox Identifiers
		⚫	\| IUPACName = 3-(1''H''-imidazol-5-yl)propyl ''N'''-imidothiocarbamate
⚫	\| CASNo=~~143407~~-29-8
		⚫	\| OtherNames = 1--''N'''-formamidine
⚫	\| PubChem=3035746

⚫	\| SMILES=C1=CC(=CC=C1CCN=C(N)SCCCC2=CN=CN2)I
		⚫	\| Section1 = {{Chembox Identifiers
⚫	\| MeSHName=Iodophenpropit
			\| CASNo_Ref = {{cascite\|correct\|??}}
		⚫	\| CASNo=145196-88-9
			\| UNII_Ref = {{fdacite\|correct\|FDA}}
			\| UNII = 3SH45L9H3Z
		⚫	\| PubChem=3035746
			\| ChemSpiderID=2299913
			\| ChEMBL_Ref = {{ebicite\|changed\|EBI}}
			\| ChEMBL = 498770
		⚫	\| SMILES=C1=CC(=CC=C1CCN=C(N)SCCCC2=CN=CN2)I
		⚫	\| MeSHName=Iodophenpropit
	}}		}}

	\|Section2={{Chembox Properties		\| Section2 = {{Chembox Properties
	\| Formula=C<sub>15</sub>H<sub>19</sub>IN<sub>4</sub>S		\| Formula = C<sub>15</sub>H<sub>19</sub>IN<sub>4</sub>S
	\| MolarMass=414.30763		\| MolarMass = 414.30763 g/mol
	\| Appearance=
			\| Appearance =
	\| Density=
			\| Density =
	\| MeltingPt=
			\| MeltingPt =
	\| BoilingPt=
			\| BoilingPt =
	\| Solubility=
			\| Solubility =
	}}		}}

	\|Section3={{Chembox Hazards		\| Section3 = {{Chembox Hazards
	\| MainHazards=
			\| MainHazards =
	\| FlashPt=
			\| FlashPt =
	\| Autoignition=
			\| AutoignitionPt =
	}}		}}
	}}		}}

	'''Iodophenpropit''' is a ] which binds selectively to the ] subtype. Its <sup>125</sup>I ] form is used for mapping the distribution of H<sub>3</sub> receptors in ~~the~~ ~~body~~.<ref>Jansen FP, Wu TS, Voss HP, Steinbusch HW, Vollinga RC, Rademaker B, Bast A, Timmerman H. Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, -iodophenpropit, to rat brain. ''British Journal of Pharmacology~~''.~~ ~~1994~~ ~~Oct;~~113(2~~):355-62.~~ ~~PMID~~ 7834183</ref><ref>Jansen FP, Mochizuki T, Maeyama K, Leurs R, Timmerman H. Characterization of histamine H3 receptors in mouse brain using the H3 antagonist ~~iodophenpropit.~~ ~~''Naunyn~~ ~~Schmiedebergs~~ Archives of Pharmacology~~''.~~ ~~2000~~ ~~Jul;~~362(1~~):60-7.~~ ~~PMID~~ 10935534</ref>		'''Iodophenpropit''' is a ] which binds selectively to the ]. Its <sup>125</sup>I ] form has been used for mapping the distribution of H<sub>3</sub> receptors in animal studies.<ref>{{cite journal \| last1 = Jansen \| first1 = FP \| last2 = Wu \| first2 = TS \| last3 = Voss \| first3 = HP \| last4 = Steinbusch \| first4 = HW \| last5 = Vollinga \| first5 = RC \| last6 = Rademaker \| first6 = B \| last7 = Bast \| first7 = A \| last8 = Timmerman \| first8 = H \| title = Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain \| journal = ] \| volume = 113 \| issue = 2 \| pages = 355–62 \| year = 1994 \| pmid = 7834183 \| pmc = 1510107 \| doi=10.1111/j.1476-5381.1994.tb16995.x}}</ref><ref>{{cite journal \| last1 = Jansen \| first1 = FP \| last2 = Mochizuki \| first2 = T \| last3 = Maeyama \| first3 = K \| last4 = Leurs \| first4 = R \| last5 = Timmerman \| first5 = H \| title = Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit \| journal = Naunyn-Schmiedeberg's Archives of Pharmacology \| volume = 362 \| issue = 1 \| pages = 60–7 \| year = 2000 \| pmid = 10935534 \| doi = 10.1007/s002100000227 \| s2cid = 21293180 }}</ref>

	==References==		==References==
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	{{pharm-stub}}		{{pharm-stub}}

Latest revision as of 15:56, 7 September 2024

Iodophenpropit
Names

IUPAC name 3-(1H-imidazol-5-yl)propyl N'-imidothiocarbamate
Other names 1--N'-formamidine
Identifiers
CAS Number	145196-88-9
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL498770
ChemSpider	2299913
MeSH	Iodophenpropit
PubChem CID	3035746
UNII	3SH45L9H3Z
CompTox Dashboard (EPA)	DTXSID20273996
SMILES C1=CC(=CC=C1CCN=C(N)SCCCC2=CN=CN2)I
Properties
Chemical formula	C₁₅H₁₉IN₄S
Molar mass	414.30763 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is ?) Infobox references

Chemical compound

Iodophenpropit is a histamine antagonist which binds selectively to the H₃ subtype. Its I radiolabelled form has been used for mapping the distribution of H₃ receptors in animal studies.

References

Jansen, FP; Wu, TS; Voss, HP; Steinbusch, HW; Vollinga, RC; Rademaker, B; Bast, A; Timmerman, H (1994). "Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain". British Journal of Pharmacology. 113 (2): 355–62. doi:10.1111/j.1476-5381.1994.tb16995.x. PMC 1510107. PMID 7834183.
Jansen, FP; Mochizuki, T; Maeyama, K; Leurs, R; Timmerman, H (2000). "Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit". Naunyn-Schmiedeberg's Archives of Pharmacology. 362 (1): 60–7. doi:10.1007/s002100000227. PMID 10935534. S2CID 21293180.

Histamine receptor modulators

H₁

Agonists

Antagonists

Others: Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, brilaroxazine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone, zotepine)
Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione)
Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline, mianserin, mirtazapine, oxaprotiline)
Tricyclic antidepressants (e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin (dothiepin), doxepin, imipramine, iprindole, lofepramine, nortriptyline, protriptyline, trimipramine)
Typical antipsychotics (e.g., chlorpromazine, flupenthixol, fluphenazine, loxapine, perphenazine, prochlorperazine, thioridazine, thiothixene)

H₂

Agonists	Amthamine Betazole Dimaprit Histamine HTMT Impromidine L-Histidine UR-AK49
Antagonists	Bisfentidine Burimamide Cimetidine Dalcotidine Donetidine Ebrotidine Etintidine Famotidine Isolamtidine Lafutidine Lamtidine Lavoltidine (loxtidine) Lupitidine Metiamide Mifentidine Niperotidine Nizatidine Osutidine Oxmetidine Pibutidine Quisultazine (quisultidine) Ramixotidine Ranitidine Roxatidine Sufotidine Tiotidine Tuvatidine Venritidine Xaltidine Zolantidine

H₃

Agonists	α-Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine L-Histidine Methimepip Proxyfan
Antagonists	A-349821 A-423579 ABT-239 ABT-652 AZD5213 Bavisant Betahistine Burimamide Ciproxifan Clobenpropit Conessine Enerisant GSK-189254 Impentamine Iodophenpropit Irdabisant JNJ-5207852 NNC 38-1049 PF-03654746 Pitolisant SCH-79687 Thioperamide VUF-5681

H₄

Agonists	4-Methylhistamine α-Methylhistamine Histamine L-Histidine OUP-16 VUF-8430
Antagonists	JNJ-7777120 Mianserin Seliforant Thioperamide Toreforant VUF-6002

See also: Receptor/signaling modulators; Monoamine metabolism modulators; Monoamine reuptake inhibitors

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