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{{Short description|Chemical compound}}
{{Unreferenced|date=November 2009}}
{{drugbox {{Drugbox
⚫ | verifiedrevid = 437205813
| Verifiedfields = changed
⚫ | IUPAC_name = 7-Chloro-3-quinazolin-4-one
⚫ | UNII_Ref = {{fdacite|changed|FDA}}
⚫ | image = Albaconazole.svg
⚫ | UNII = YDW24Y8IAB

⚫ | verifiedrevid = 413307952
<!--Clinical data-->
⚫ | IUPAC_name = 7-chloro-3-quinazolin-4-one
| tradename =
⚫ | image = Albaconazole.svg
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫ | pregnancy_US = <!-- A / B / C / D / X -->
⚫ | pregnancy_category =
⚫ | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
⚫ | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
⚫ | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
⚫ | legal_status =
⚫ | routes_of_administration =

<!--Pharmacokinetic data-->
⚫ | bioavailability =
⚫ | protein_bound =
⚫ | metabolism =
⚫ | elimination_half-life =
⚫ | excretion =

<!--Identifiers-->
⚫ | CAS_number_Ref = {{cascite|correct|??}}
⚫ | CAS_number = 187949-02-6
⚫ | ATC_prefix = none
⚫ | ATC_suffix =
⚫ | ATC_supplemental =
⚫ | PubChem = 208952
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
⚫ | DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 181045 | ChemSpiderID = 181045
⚫ | UNII_Ref = {{fdacite|correct|FDA}}
| InChI = 1/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1
⚫ | UNII = YDW24Y8IAB
| InChIKey = UHIXWHUVLCAJQL-MPBGBICIBS
| KEGG_Ref = {{keggcite|correct|kegg}}
⚫ | smiles = Fc1ccc(c(F)c1)(O)((N3\C=N/c2cc(Cl)ccc2C3=O)C)Cn4ncnc4
⚫ | KEGG = D09702
| ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 298817 | ChEMBL = 298817

<!--Chemical data-->
⚫ | chemical_formula =
⚫ | C=20 | H=16 | Cl=1 | F=2 | N=5 | O=2
⚫ | smiles = Fc1ccc(c(F)c1)(O)((N3\C=N/c2cc(Cl)ccc2C3=O)C)Cn4ncnc4
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1 | StdInChI = 1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = UHIXWHUVLCAJQL-MPBGBICISA-N | StdInChIKey = UHIXWHUVLCAJQL-MPBGBICISA-N
⚫ | CAS_number = 187949-02-6
| CAS_supplemental =
⚫ | ATC_prefix = none
⚫ | ATC_suffix =
⚫ | ATC_supplemental =
⚫ | PubChem = 208952
⚫ | DrugBank =
⚫ | KEGG_Ref = {{keggcite|correct|kegg}}
⚫ | KEGG = D09702
⚫ | chemical_formula =
⚫ | C=20 | H=16 | Cl=1 | F=2 | N=5 | O=2
| molecular_weight = 431.823146 g/mol
⚫ | bioavailability =
⚫ | protein_bound =
⚫ | metabolism =
⚫ | elimination_half-life =
⚫ | excretion =
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫ | pregnancy_US = <!-- A / B / C / D / X -->
⚫ | pregnancy_category=
⚫ | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
⚫ | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫ | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
⚫ | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
⚫ | legal_status =
⚫ | routes_of_administration =
}} }}


'''Albaconazole (UR-9825)''' is a ] antifungal. It has potential broad-spectrum activity. '''Albaconazole''' (development code '''UR-9825''') is an experimental ] antifungal.<ref>{{cite web | url = https://adisinsight.springer.com/drugs/800009452 | title = Albaconazole | work = Adis Insight | publisher = Springer Nature Switzerland AG }}</ref> It has potential broad-spectrum activity. The drug blocks a number of ] liver enzymes.{{cn|date=December 2022}}


It has also been studied as an ] agent.<ref>{{cite journal | vauthors = Guedes PM, Urbina JA, de Lana M, Afonso LC, Veloso VM, Tafuri WL, Machado-Coelho GL, Chiari E, Bahia MT | display-authors = 6 | title = Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts | journal = Antimicrobial Agents and Chemotherapy | volume = 48 | issue = 11 | pages = 4286–92 | date = November 2004 | pmid = 15504854 | pmc = 525424 | doi = 10.1128/AAC.48.11.4286-4292.2004 }}</ref>
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]


== References ==
{{Reflist}}

{{Antifungals}}

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{{antiinfective-agent-stub}} {{antiinfective-agent-stub}}

Latest revision as of 15:06, 16 March 2023

Chemical compound Pharmaceutical compound
Albaconazole
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • 7-Chloro-3-quinazolin-4-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.170.829 Edit this at Wikidata
Chemical and physical data
FormulaC20H16ClF2N5O2
Molar mass431.83 g·mol
3D model (JSmol)
SMILES
  • Fc1ccc(c(F)c1)(O)((N3\C=N/c2cc(Cl)ccc2C3=O)C)Cn4ncnc4
InChI
  • InChI=1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1
  • Key:UHIXWHUVLCAJQL-MPBGBICISA-N
  (verify)

Albaconazole (development code UR-9825) is an experimental triazole antifungal. It has potential broad-spectrum activity. The drug blocks a number of CYP450 liver enzymes.

It has also been studied as an antiprotozoal agent.

References

  1. "Albaconazole". Adis Insight. Springer Nature Switzerland AG.
  2. Guedes PM, Urbina JA, de Lana M, Afonso LC, Veloso VM, Tafuri WL, et al. (November 2004). "Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts". Antimicrobial Agents and Chemotherapy. 48 (11): 4286–92. doi:10.1128/AAC.48.11.4286-4292.2004. PMC 525424. PMID 15504854.
Antifungals (D01 and J02)
Wall/
membrane
Ergosterol
inhibitors
Azoles (lanosterol 14α-
demethylase inhibitors)
Imidazoles
  • Systemic: ketoconazole
Triazoles
Thiazoles
Polyene antimycotics
(ergosterol binding)
Squalene monooxygenase
inhibitors
Allylamines
Benzylamines
Others
β-glucan synthase
inhibitors
Intracellular
Pyrimidine analogues/
thymidylate synthase inhibitors
Mitotic inhibitors
Aminoacyl tRNA synthetase inhibitors
Others
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