Felbinac: Difference between revisions

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			{{Short description\|Topical NSAID medication}}
	{{drugbox
			{{Drugbox
	\| Verifiedfields = changed
	\| ~~UNII_Ref~~ = ~~{{fdacite\|~~changed~~\|FDA}}~~		\| Watchedfields = changed
		⚫	\| verifiedrevid = 443752362
⚫	\| UNII = 94WNJ5U8L7
		⚫	\| IUPAC_name = biphenyl-4-ylacetic acid
⚫	\| verifiedrevid = ~~415333733~~
		⚫	\| image = Felbinac.svg
⚫	\| IUPAC_name = biphenyl-4-ylacetic acid
			\| image_class = skin-invert-image
⚫	\| image = Felbinac.svg

			<!--Clinical data-->
			\| tradename =
			\| Drugs.com = {{drugs.com\|international\|felbinac}}
		⚫	\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
		⚫	\| pregnancy_US = <!-- A / B / C / D / X -->
		⚫	\| pregnancy_category =
		⚫	\| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
		⚫	\| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
		⚫	\| legal_UK = P
		⚫	\| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
		⚫	\| legal_status =
		⚫	\| routes_of_administration = Topical

			<!--Pharmacokinetic data-->
		⚫	\| bioavailability =
		⚫	\| protein_bound =
		⚫	\| metabolism =
		⚫	\| elimination_half-life =
		⚫	\| excretion =

			<!--Identifiers-->
		⚫	\| CAS_number = 5728-52-9
		⚫	\| ATC_prefix = M02
		⚫	\| ATC_suffix = AA08
		⚫	\| PubChem = 3332
		⚫	\| DrugBank_Ref = {{drugbankcite\|correct\|drugbank}}
		⚫	\| DrugBank = DB07477
	\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}		\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}
	\| ChemSpiderID = 3215		\| ChemSpiderID = 3215
		⚫	\| UNII_Ref = {{fdacite\|correct\|FDA}}
	\| InChI = 1/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)
		⚫	\| UNII = 94WNJ5U8L7
	\| InChIKey = QRZAKQDHEVVFRX-UHFFFAOYAC
			\| KEGG_Ref = {{keggcite\|correct\|kegg}}
⚫	\| smiles = O=C(O)Cc1ccc(cc1)c2ccccc2
		⚫	\| KEGG = D01675
			\| ChEBI_Ref = {{ebicite\|correct\|EBI}}
		⚫	\| ChEBI = 31597
	\| ChEMBL_Ref = {{ebicite\|correct\|EBI}}		\| ChEMBL_Ref = {{ebicite\|correct\|EBI}}
	\| ChEMBL = 413965		\| ChEMBL = 413965

			<!--Chemical data-->
		⚫	\| C=14 \| H=12 \| O=2
		⚫	\| smiles = O=C(O)Cc1ccc(cc1)c2ccccc2
	\| StdInChI_Ref = {{stdinchicite\|correct\|chemspider}}		\| StdInChI_Ref = {{stdinchicite\|correct\|chemspider}}
	\| StdInChI = 1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)		\| StdInChI = 1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)
	\| StdInChIKey_Ref = {{stdinchicite\|correct\|chemspider}}		\| StdInChIKey_Ref = {{stdinchicite\|correct\|chemspider}}
	\| StdInChIKey = QRZAKQDHEVVFRX-UHFFFAOYSA-N		\| StdInChIKey = QRZAKQDHEVVFRX-UHFFFAOYSA-N
⚫	\| CAS_number = 5728-52-9
⚫	\| ATC_prefix = M02
⚫	\| ATC_suffix = AA08
⚫	\| ChEBI = 31597
⚫	\| PubChem = 3332
⚫	\| DrugBank_Ref = {{drugbankcite\|correct\|drugbank}}
⚫	\| DrugBank = DB07477
⚫	\| ~~KEGG_Ref~~ = {{~~keggcite~~\|correct\|~~kegg~~}}
⚫	\| KEGG = D01675
⚫	\| C=14\|H=12\|O=2
	\| molecular_weight = 212.244 g/mol
⚫	\| bioavailability =
⚫	\| protein_bound =
⚫	\| metabolism =
⚫	\| elimination_half-life =
⚫	\| excretion =
⚫	\| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫	\| pregnancy_US = <!-- A / B / C / D / X -->
⚫	\| pregnancy_category=
⚫	\| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
⚫	\| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫	\| legal_UK = P
⚫	\| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
⚫	\| legal_status =
⚫	\| routes_of_administration = Topical
	}}		}}
⚫	'''Felbinac''' (]) (or '''biphenylylacetic acid''') is a ] medicine, belonging to the family of medicines known as ] (NSAIDs) of the arylpropionic acid class, which is used to treat muscle inflammation and ]. It is an active metabolite of ].<ref name="KTWE1980">{{cite journal \| ~~author~~=Kohler C, Tolman E, Wooding W, Ellenbogen L. \| title=A review of the effects of fenbufen and a metabolite, biphenylacetic acid, on platelet biochemistry and function \| journal=Arzneimittelforschung \| volume=30 \| issue=4A \| pages=702–707 \| year=1980 \| pmid=6254545}}</ref>

		⚫	'''Felbinac''' (], or '''biphenylylacetic acid''') is a ] medicine,<ref>''The Merck Index'', 12th Edition. 3989</ref> belonging to the family of medicines known as ]s (NSAIDs) of the arylacetic acid (not arylpropionic acid) class, which is used to treat muscle inflammation and ].<ref>Description of Felbinac on Tiscali </ref> It is an active metabolite of ].<ref name="KTWE1980">{{cite journal \|vauthors=Kohler C, Tolman E, Wooding W, Ellenbogen L \| title=A review of the effects of fenbufen and a metabolite, biphenylacetic acid, on platelet biochemistry and function \| journal=Arzneimittelforschung \| volume=30 \| issue=4A \| pages=702–707 \| year=1980 \| pmid=6254545}}</ref>
	== Footnotes ==
⚫	{{Reflist}}

	== ~~References~~ ==		==Related compounds==
			The α-methyl acid of felbinac is called ] and is used to prepare ]. The α-ethyl acid is called ] which is used to make ].
	{{refbegin}}
	* The Merck Index, 12th Edition. 3989
	* Description of Felbinac on Tiscali
	{{refend}}

			==See also==
	{{med-stub}}
			*]

			== References ==
		⚫	{{Reflist}}

	{{NSAIDs}}		{{NSAIDs}}
	{{Topical products for joint and muscular pain}}		{{Topical products for joint and muscular pain}}
			{{Prostanoidergics}}

		⚫	]

⚫	]

			{{musculoskeletal-drug-stub}}
	]

Latest revision as of 22:11, 10 January 2025

Topical NSAID medication Pharmaceutical compound

Felbinac
Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Topical
ATC code	M02AA08 (WHO)
Legal status
Legal status	UK: P (Pharmacy medicines)
Identifiers
IUPAC name biphenyl-4-ylacetic acid
CAS Number	5728-52-9
PubChem CID	3332
DrugBank	DB07477
ChemSpider	3215
UNII	94WNJ5U8L7
KEGG	D01675
ChEBI	CHEBI:31597
ChEMBL	ChEMBL413965
CompTox Dashboard (EPA)	DTXSID0045389
ECHA InfoCard	100.024.758
Chemical and physical data
Formula	C₁₄H₁₂O₂
Molar mass	212.248 g·mol
3D model (JSmol)	Interactive image
SMILES O=C(O)Cc1ccc(cc1)c2ccccc2
InChI InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16) Key:QRZAKQDHEVVFRX-UHFFFAOYSA-N
(verify)

Felbinac (INN, or biphenylylacetic acid) is a topical medicine, belonging to the family of medicines known as nonsteroidal anti-inflammatory drugs (NSAIDs) of the arylacetic acid (not arylpropionic acid) class, which is used to treat muscle inflammation and arthritis. It is an active metabolite of fenbufen.

Related compounds

The α-methyl acid of felbinac is called biprofen and is used to prepare bifepramide. The α-ethyl acid is called xenbucin which is used to make xenthiorate.

References

The Merck Index, 12th Edition. 3989
Description of Felbinac on Tiscali
Kohler C, Tolman E, Wooding W, Ellenbogen L (1980). "A review of the effects of fenbufen and a metabolite, biphenylacetic acid, on platelet biochemistry and function". Arzneimittelforschung. 30 (4A): 702–707. PMID 6254545.

v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones / pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone
salicylates	Aspirin (acetylsalicylic acid) Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bufexamac Bumadizone Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Mofezolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac
oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Pivoxicam Tenoxicam
propionic acid derivatives (profens)	Alminoprofen Benoxaprofen Carprofen Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen Ibuproxam Indoprofen Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pelubiprofen Piketoprofen Pirprofen Suprofen Tarenflurbil Tepoxalin Tiaprofenic acid Vedaprofen Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
n-arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Floctafenine Flufenamic acid Flunixin Flutiazin Glafenine Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid
COX-2 inhibitors (coxibs)	Apricoxib Celecoxib (+tramadol) Cimicoxib Deracoxib Etoricoxib Firocoxib Lumiracoxib Mavacoxib Parecoxib Robenacoxib Rofecoxib Valdecoxib
other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase / orgotein Tenidap
NSAID combinations	Ibuprofen/famotidine Ibuprofen/hydrocodone Ibuprofen/oxycodone Ibuprofen/paracetamol Meloxicam/bupivacaine Naproxen/diphenhydramine Naproxen/esomeprazole
Key: underline indicates initially developed first-in-class compound of specific group; WHO-Essential Medicines; withdrawn drugs; veterinary use.
category [REDACTED] commons portal

Topical products for joint and muscular pain (M02)

Anti-inflammatory
preparations,
non-steroids

Pyrazolidines	Clofezone Mofebutazone Oxyphenbutazone Phenylbutazone
Acetic acid derivatives	Diclofenac Fentiazac Tolmetin
Other	Bendazac Benzydamine Bufexamac Etofenamate Felbinac Feprazone Flurbiprofen Ibuprofen Indometacin Ketoprofen Meclofenamic acid Naproxen Nifenazone Niflumic acid Piketoprofen Piroxicam Suxibuzone

Capsaicin derivatives

Zucapsaicin

Other

Prostanoid signaling modulators

Receptor
(ligands)

DP (D₂)Tooltip Prostaglandin D2 receptor

DP₁Tooltip Prostaglandin D2 receptor 1

Agonists: Prostaglandin D₂
Treprostinil

DP₂Tooltip Prostaglandin D2 receptor 2

Agonists: Indometacin
Prostaglandin D₂

EP (E₂)Tooltip Prostaglandin E2 receptor

EP₁Tooltip Prostaglandin EP1 receptor	Agonists: Beraprost Enprostil Iloprost (ciloprost) Latanoprost Lubiprostone Misoprostol Prostaglandin E₁ (alprostadil) Prostaglandin E₂ (dinoprostone) Sulprostone Antagonists: AH-6809 ONO-8130 SC-19220 SC-51089 SC-51322
EP₂Tooltip Prostaglandin EP2 receptor	Agonists: Butaprost Misoprostol Prostaglandin E₁ (alprostadil) Prostaglandin E₂ (dinoprostone) Treprostinil Antagonists: AH-6809 PF-04418948 TG 4-155
EP₃Tooltip Prostaglandin EP3 receptor	Agonists: Beraprost Carbacyclin Cicaprost Enprostil Iloprost (ciloprost) Isocarbacyclin Latanoprost Misoprostol Prostaglandin D₂ Prostaglandin E₁ (alprostadil) Prostaglandin E₂ (dinoprostone) Remiprostol Ricinoleic acid Sulprostone Antagonists: L-798106
EP₄Tooltip Prostaglandin EP4 receptor	Agonists: Lubiprostone Misoprostol Prostaglandin E₁ (alprostadil) Prostaglandin E₂ (dinoprostone) TCS-2510 Antagonists: Grapiprant GW-627368 L-161982 ONO-AE3-208
Unsorted	Agonists: 16,16-Dimethyl Prostaglandin E₂ Aganepag Carboprost Evatanepag Gemeprost Nocloprost Omidenepag Prostaglandin F_2α (dinoprost) Simenepag Taprenepag

FP (F_2α)Tooltip Prostaglandin F receptor

IP (I₂)Tooltip Prostacyclin receptor

Agonists: ACT-333679
AFP-07
Beraprost
BMY-45778
Carbacyclin
Cicaprost
Iloprost (ciloprost)
Isocarbacyclin
MRE-269
NS-304
Prostacyclin (prostaglandin I₂, epoprostenol)
Prostaglandin E₁ (alprostadil)
Ralinepag
Selexipag
Taprostene
TRA-418
Treprostinil

Antagonists: RO1138452

TP (TX_A2)Tooltip Thromboxane receptor

Agonists: Carbocyclic thromboxane A₂
I-BOP
Thromboxane A₂
U-46619
Vapiprost

Unsorted

Enzyme
(inhibitors)

COX (PTGS)	Salicylic acids: Aloxiprin Aspirin (acetylsalicylic acid) Benorilate (benorylate) Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Mesalazine (5-aminosalicylic acid) Methyl salicylate Salacetamide Salicin Salicylamide Salicylate (salicylic acid) Salsalate Sodium salicylate Triflusal; Acetic acids: Aceclofenac Acemetacin Aclofenac Amfenac Alclofenac Bendazac Bromfenac Bufexamac Bumadizone Cinmetacin Clometacin Diclofenac Difenpiramide Etodolac Felbinac Fenclofenac Fentiazac Glucametacin Indometacin (indomethacin) Indometacin farnesil Ketorolac Lonazolac Mofezolac Nabumetone Oxametacin Oxindanac Proglumetacin Sulindac Sulindac sulfide Tolmetin Zidometacin Zomepirac; Propionic acids: Alminoprofen Benoxaprofen Bucloxic acid (blucloxate) Butibufen Carprofen Dexibuprofen Dexindoprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen Ibuproxam Indoprofen Ketoprofen Loxoprofen Miroprofen Naproxen Naproxcinod Oxaprozin Pirprofen Pranoprofen Suprofen Tarenflurbil Tepoxalin Tiaprofenic acid (tiaprofenate) Vedaprofen; Anthranilic acids (fenamic acids): Etofenamic acid (etofenamate) Floctafenic acid (floctafenate) Flufenamic acid (flufenamate) Meclofenamic acid (meclofenamate) Mefenamic acid (mefenamate) Morniflumic acid (morniflumate) Niflumic acid (niflumate) Talinflumic acid (talinflumate) Tolfenamic acid (tolfenamate); Pyrazolones: Azapropazone Dipyrone Isopyrin Oxyphenbutazone Phenylbutazone; Enolic acids (oxicams): Ampiroxicam Droxicam Enolicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam; 4-Aminoquinolines: Antrafenine Floctafenine Glafenine; Quinazolines: Fluproquazone Proquazone; Aminonicotinic acids: Clonixeril Clonixin Flunixin; Sulfonanilides: Flosulide Nimesulide; Aminophenols (anilines): Acetanilide AM-404 (N-arachidonoylaminophenol) Bucetin Paracetamol (acetaminophen) Parapropamol Phenacetin Propacetamol; Selective COX-2 inhibitors (coxibs): Apricoxib Celecoxib Cimicoxib Deracoxib Etoricoxib Firocoxib Lumiracoxib Mavacoxib Parecoxib Polmacoxib Robenacoxib Rofecoxib Tilmacoxib Valdecoxib; Others/unsorted: Anitrazafen Clobuzarit Curcumin DuP-697 FK-3311 Flumizole FR-122047 Glimepiride Hyperforin Itazigrel L-655240 L-670596 Licofelone Menatetrenone (vitamin K₂) NCX-466 NCX-4040 NS-398 Pamicogrel Resveratrol Romazarit Rosmarinic acid Rutecarpine Satigrel SC-236 SC-560 SC-58125 Tenidap Tiflamizole Timegadine Trifenagrel Tropesin
PGD₂STooltip Prostaglandin D synthase	Retinoids Selenium (selenium tetrachloride, sodium selenite, selenium disulfide)
PGESTooltip Prostaglandin E synthase	HQL-79
PGFSTooltip Prostaglandin F synthase	Bimatoprost
PGI₂STooltip Prostacyclin synthase	Tranylcypromine
TXASTooltip Thromboxane A synthase	Camonagrel Dazmegrel Dazoxiben Furegrelate Isbogrel Midazogrel Nafagrel Nicogrelate Ozagrel Picotamide Pirmagrel Ridogrel Rolafagrel Samixogrel Terbogrel U63557A

Others

See also: Receptor/signaling modulators; Leukotriene signaling modulators

This drug article relating to the musculoskeletal system is a stub. You can help Misplaced Pages by expanding it.

Categories:

Latest revision as of 22:11, 10 January 2025

Related compounds

See also

References