5-Hydroxyisourate: Difference between revisions

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Revision as of 14:57, 11 August 2011 editCheMoBot (talk \| contribs)Bots141,565 edits Updating {{chembox}} (no changed fields - added verified revid - updated 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref') per Chem/Drugbox validation (report [[Wikipedia_talk:WikiProject_Chemicals\|error← Previous edit		Latest revision as of 16:16, 18 March 2023 edit undoSmokefoot (talk \| contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers, Rollbackers75,022 edits replace obsolete ref
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	{{Unreferenced stub\|auto=yes\|date=December 2009}}
	{{Chembox		{{Chembox
			\| Verifiedfields = changed
	\| verifiedrevid = ~~443356181~~		\| verifiedrevid = 477224617
	\|ImageFile=5-Hydroxyisourate.svg		\| ImageFile=5-Hydroxyisourate.svg
	\|ImageSize=		\| ImageSize=
	\|IUPACName=5-hydroxy-3,7-dihydropurine-2,6,8-trione		\| IUPACName=5-hydroxy-3,7-dihydropurine-2,6,8-trione
	\|OtherNames=		\| OtherNames=
	\|Section1= {{Chembox Identifiers		\|Section1={{Chembox Identifiers
	\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}		\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}
	\| ChemSpiderID = 219288		\| ChemSpiderID = 219288
	\| KEGG_Ref = {{keggcite\|correct\|kegg}}		\| KEGG_Ref = {{keggcite\|correct\|kegg}}
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	\| StdInChIKey_Ref = {{stdinchicite\|correct\|chemspider}}		\| StdInChIKey_Ref = {{stdinchicite\|correct\|chemspider}}
	\| StdInChIKey = LTQYPAVLAYVKTK-UHFFFAOYSA-N		\| StdInChIKey = LTQYPAVLAYVKTK-UHFFFAOYSA-N
		⚫	\| CASNo_Ref = {{cascite\|correct\|CAS}}
	\| CASNo=6960-30-1		\| CASNo=6960-30-1
			\| UNII_Ref = {{fdacite\|correct\|FDA}}
⚫	\| PubChem=250388
			\| UNII = DU6PJ7L9BX
⚫	\| ~~ChEBI_Ref~~ = {{~~ebicite~~\|correct\|~~EBI~~}}
		⚫	\| PubChem=250388
			\| ChEBI_Ref = {{ebicite\|correct\|EBI}}
	\| ChEBI = 18072		\| ChEBI = 18072
	\| SMILES=C12=NC(=O)NC1(C(=O)NC(=O)N2)O		\| SMILES=C12=NC(=O)NC1(C(=O)NC(=O)N2)O
	\| MeSHName=5-Hydroxyisourate		\| MeSHName=5-Hydroxyisourate
	}}		}}
	\|Section2= {{Chembox Properties		\|Section2={{Chembox Properties
	\| Formula=C<sub>5</sub>H<sub>4</sub>N<sub>4</sub>O<sub>4</sub>		\| Formula=C<sub>5</sub>H<sub>4</sub>N<sub>4</sub>O<sub>4</sub>
	\| MolarMass=184.11 g/mol		\| MolarMass=184.11 g/mol
	\| Appearance=		\| Appearance=
	\| Density=		\| Density=
	\| MeltingPt=		\| MeltingPt=
	\| BoilingPt=		\| BoilingPt=
	\| Solubility=		\| Solubility=
	}}		}}
	\|Section3= {{Chembox Hazards		\|Section3={{Chembox Hazards
	\| MainHazards=		\| MainHazards=
	\| FlashPt=		\| FlashPt=
			\| AutoignitionPt =
	\| Autoignition=
	}}		}}
	}}		}}

			'''5-Hydroxyisourate''' is an ] that is produced by the ] of ]. The conversion is a major pathway in the antioxidant properties of urate. The conversion is catalysed by ].<ref>{{cite journal \| vauthors = Oksanen E, Blakeley MP, El-Hajji M, Ryde U, Budayova-Spano M \| title = The Neutron Structure of Urate Oxidase Resolves a Long-Standing Mechanistic Conundrum and Reveals Unexpected Changes in Protonation \| journal = PLOS ONE \| volume = 9 \| issue = 1 \| pages = e86651 \| date = 2014-01-23 \| pmid = 24466188 \| pmc = 3900588 \| doi = 10.1371/journal.pone.0086651 \| bibcode = 2014PLoSO...986651O \| doi-access = free }}</ref><ref>{{cite journal \|doi=10.1007/s00253-010-2455-0\|title=Cofactor-independent oxidases and oxygenases \|year=2010 \|last1=Fetzner \|first1=Susanne \|last2=Steiner \|first2=Roberto A. \|journal=Applied Microbiology and Biotechnology \|volume=86 \|issue=3 \|pages=791–804 \|pmid=20157809 \|s2cid=25377247 }}</ref>
	'''5-Hydroxyisourate''' is a ] with a formula of C<sub>5</sub>H<sub>4</sub>N<sub>4</sub>O<sub>4</sub> and molecular weight of 184.110 g/mol. It is the product of the ] of ] by ].
			]
			5-Hydroxyisourate rearranges to ].

			==References==
			{{reflist}}

	==See also==		==See also==
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	]		]

	]
	]

Latest revision as of 16:16, 18 March 2023

5-Hydroxyisourate
Names

IUPAC name 5-hydroxy-3,7-dihydropurine-2,6,8-trione
Identifiers
CAS Number	6960-30-1
3D model (JSmol)	Interactive image Interactive image
ChEBI	CHEBI:18072
ChemSpider	219288
KEGG	C11821
MeSH	5-Hydroxyisourate
PubChem CID	250388
UNII	DU6PJ7L9BX
CompTox Dashboard (EPA)	DTXSID10290591
InChI InChI=1S/C5H4N4O4/c10-2-5(13)1(6-3(11)8-2)7-4(12)9-5/h13H,(H3,6,7,8,9,10,11,12)Key: LTQYPAVLAYVKTK-UHFFFAOYSA-N InChI=1/C5H4N4O4/c10-2-5(13)1(6-3(11)8-2)7-4(12)9-5/h13H,(H3,6,7,8,9,10,11,12)Key: LTQYPAVLAYVKTK-UHFFFAOYAS
SMILES C12=NC(=O)NC1(C(=O)NC(=O)N2)O O=C1NC(=O)N/C2=N/C(=O)NC12O
Properties
Chemical formula	C₅H₄N₄O₄
Molar mass	184.11 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is ?) Infobox references

Chemical compound

5-Hydroxyisourate is an organic compound that is produced by the oxidation of uric acid. The conversion is a major pathway in the antioxidant properties of urate. The conversion is catalysed by urate oxidase.

5-Hydroxyisourate rearranges to allantoin.

References

Oksanen E, Blakeley MP, El-Hajji M, Ryde U, Budayova-Spano M (2014-01-23). "The Neutron Structure of Urate Oxidase Resolves a Long-Standing Mechanistic Conundrum and Reveals Unexpected Changes in Protonation". PLOS ONE. 9 (1): e86651. Bibcode:2014PLoSO...986651O. doi:10.1371/journal.pone.0086651. PMC 3900588. PMID 24466188.
Fetzner, Susanne; Steiner, Roberto A. (2010). "Cofactor-independent oxidases and oxygenases". Applied Microbiology and Biotechnology. 86 (3): 791–804. doi:10.1007/s00253-010-2455-0. PMID 20157809. S2CID 25377247.

Latest revision as of 16:16, 18 March 2023

References

See also