| Revision as of 19:24, 1 September 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (changes to watched fields - updated 'ChemSpiderID_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WikiProject_Pha← Previous edit |
Latest revision as of 09:23, 13 November 2024 edit undoCbare (talk | contribs)104 editsm Add DrugBank accession |
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{{Short description|Chemical compound}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| Watchedfields = changed |
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| Watchedfields = changed |
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| verifiedrevid = 444070509 |
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| verifiedrevid = 447906208 |
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| IUPAC_name = 2-propylpyridine-4-carbothioamide |
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| IUPAC_name = 2-propylpyridine-4-carbothioamide |
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| image = protionamide.png |
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| image = Protionamide.svg |
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| image2 = Prothionamide 3D ball.png |
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<!--Clinical data--> |
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<!--Clinical data--> |
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| tradename = |
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| tradename = |
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| Drugs.com = {{drugs.com|international|prothionamide}} |
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| Drugs.com = {{drugs.com|international|prothionamide}} |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
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| pregnancy_category = |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
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| legal_status = |
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| routes_of_administration = |
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| routes_of_administration = |
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<!--Pharmacokinetic data--> |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| bioavailability = |
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| protein_bound = |
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| protein_bound = |
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| metabolism = |
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| metabolism = |
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| elimination_half-life = |
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| elimination_half-life = |
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| excretion = |
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| excretion = |
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<!--Identifiers--> |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 14222-60-7 |
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| CAS_number = 14222-60-7 |
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| ATC_prefix = J04 |
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| ATC_prefix = J04 |
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| PubChem = 666418 |
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| PubChem = 666418 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| DrugBank = DB12667 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 76YOO33643 |
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| UNII = 76YOO33643 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 579891 |
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<!--Chemical data--> |
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<!--Chemical data--> |
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| C=9 | H=12 | N=2 | S=1 |
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| C=9 | H=12 | N=2 | S=1 |
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| smiles = CCCc1cc(ccn1)C(=S)N |
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| molecular_weight = 180.271 g/mol |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChI = 1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12) |
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| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChIKey = VRDIULHPQTYCLN-UHFFFAOYSA-N |
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}} |
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}} |
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'''Protionamide''' (or '''prothionamide''') is a drug used in the treatment of ].<ref name="pmid17227913">{{cite journal |author=Wang F, Langley R, Gulten G, ''et al'' |title=Mechanism of thioamide drug action against tuberculosis and leprosy |journal=J. Exp. Med. |volume=204 |issue=1 |pages=73–8 |year=2007 |month=January |pmid=17227913 |pmc=2118422 |doi=10.1084/jem.20062100 |url=http://www.jem.org/cgi/pmidlookup?view=long&pmid=17227913}}</ref> |
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It has also been tested for use in the treatment of ].<ref name="pmid16525107">{{cite journal |author=Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH |title=A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy |journal=Am. J. Trop. Med. Hyg. |volume=74 |issue=3 |pages=457–61 |year=2006 |month=March |pmid=16525107 |doi= |url=http://www.ajtmh.org/cgi/pmidlookup?view=long&pmid=16525107}}</ref> |
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'''Protionamide''' (or '''prothionamide''') is a drug used in the treatment of ] and ].<ref name="pmid17227913">{{cite journal |vauthors=Wang F, Langley R, Gulten G, etal |title=Mechanism of thioamide drug action against tuberculosis and leprosy |journal=J. Exp. Med. |volume=204 |issue=1 |pages=73–8 |date=January 2007 |pmid=17227913 |pmc=2118422 |doi=10.1084/jem.20062100 |url=http://www.jem.org/cgi/pmidlookup?view=long&pmid=17227913}}</ref><ref name="pmid16525107">{{cite journal |vauthors=Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH |title=A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy |journal=Am. J. Trop. Med. Hyg. |volume=74 |issue=3 |pages=457–61 |date=March 2006 |doi=10.4269/ajtmh.2006.74.457 |pmid=16525107 |s2cid=21415032 |url=http://www.ajtmh.org/cgi/pmidlookup?view=long&pmid=16525107|doi-access=free }}</ref> |
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==See also== |
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* ] |
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==References== |
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==References== |
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{{reflist}} |
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{{reflist}} |
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{{Antimycobacterials}} |
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{{Antimycobacterials}} |
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] |
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] |
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{{antiinfective-drug-stub}} |
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{{antiinfective-drug-stub}} |
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] |
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