Misplaced Pages

CR6261: Difference between revisions

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Browse history interactively← Previous editContent deleted Content addedVisualWikitext
Revision as of 21:46, 6 September 2011 edit58.178.233.130 (talk)No edit summary← Previous edit Latest revision as of 00:59, 13 September 2024 edit undoGraeme Bartlett (talk | contribs)Administrators249,752 edits more ids 
(13 intermediate revisions by 11 users not shown)
Line 1: Line 1:
{{Short description|Monoclonal antibody}}
{{Drugbox {{Drugbox
| Verifiedfields = changed
| verifiedrevid = 422323757 | verifiedrevid = 448818654

<!--Monoclonal antibody data--> <!-- Monoclonal antibody data -->
| type = mab | type = mab
| mab_type = | mab_type =
| source = u | source = u
| target = ] | target = ]
⚫ <!-- Clinical data -->

| tradename =
⚫ <!--Clinical data-->
| tradename = | pregnancy_AU =
| pregnancy_AU = | pregnancy_US =
| pregnancy_US =
| pregnancy_category = N/A | pregnancy_category = N/A
| legal_AU = | legal_AU =
| legal_CA = | legal_CA =
| legal_UK = | legal_UK =
| legal_US = | legal_US =
| legal_status = Investigational (animal studies) | legal_status = Investigational (animal studies)
| routes_of_administration = | routes_of_administration =
⚫ <!-- Pharmacokinetic data -->

| bioavailability =
⚫ <!--Pharmacokinetic data-->
| bioavailability = | protein_bound =
| protein_bound = | metabolism =
⚫ | elimination_half-life =
| metabolism =
⚫ | excretion =
⚫ | elimination_half-life =
⚫ <!-- Identifiers -->
⚫ | excretion =
⚫ | CAS_number =

⚫ <!--Identifiers-->
⚫ | CAS_number =
| ATC_prefix = none | ATC_prefix = none
| ATC_suffix = | ATC_suffix =
| PubChemSubstance = 194161622
| PubChem =
| ChEMBL = 3137350
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = | DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = none
<!--Chemical data--> <!-- Chemical data -->
| chemical_formula = | chemical_formula =

| molecular_weight = | molecular_weight =
}} }}
'''CR6261''' is a ]<ref>{{cite doi|10.1371/journal.pone.0009106}}</ref> that binds to a broad range of the ] including the 1918 "]" (SC1918/H1) and to a virus of the ] class of avian influenza that jumped from chickens to a human in Vietnam in 2004 (Viet04/H5). In contrast to most antibodies generated by exposure to influenza, which can only neutralize a few strains from within a single virus subtype, CR6261 neutralizes numerous strains from multiple subtypes. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of ], the predominant protein on the surface of the ]. Based upon the conservation of the amino acid sequence on this part of hemagglutinin, CR6261 is predicted to neutralize roughly 50% of all flu viruses. It was found by ] and the Dutch biopharmaceutical company, ]. '''CR6261''' is a ]<ref>{{cite journal | vauthors = Friesen RH, Koudstaal W, Koldijk MH, Weverling GJ, Brakenhoff JP, Lenting PJ, Stittelaar KJ, Osterhaus AD, Kompier R, Goudsmit J | display-authors = 6 | title = New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets | journal = PLOS ONE | volume = 5 | issue = 2 | pages = e9106 | date = February 2010 | pmid = 20161706 | pmc = 2817000 | doi = 10.1371/journal.pone.0009106 | bibcode = 2010PLoSO...5.9106F | editor1-last = Zhang | editor1-first = Linqi | doi-access = free }}</ref> that binds to a broad range of the ] including the 1918 "]" (SC1918/H1) and to a virus of the ] class of avian influenza that jumped from chickens to a human in Vietnam in 2004 (Viet04/H5). In contrast to most antibodies generated by exposure to influenza, which can only neutralize a few strains from within a single virus subtype, CR6261 neutralizes numerous strains from multiple subtypes. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of ], the predominant protein on the surface of the ]. Based upon the conservation of the amino acid sequence on this part of hemagglutinin, CR6261 is predicted to neutralize roughly 50% of all flu viruses. It was found by ] and the Dutch biopharmaceutical company, ].


==See also== == See also ==
* ] * ]


==References== == References ==
{{reflist}} {{reflist}}

⚫ *Research team finds immune molecule that attacks wide range of flu viruses
== Further reading ==
⚫ *Immune Molecule That Attacks Wide Range Of Flu Viruses Discovered
{{refbegin}}
*Antibody Recognition of a Highly Conserved Influenza Virus Epitope
⚫ * {{cite web | title = Research team finds immune molecule that attacks wide range of flu viruses | url = http://www.physorg.com/news154880861.html | work = physorg.com | date = 26 February 2009 }}
⚫ * {{cite web | title = Immune Molecule That Attacks Wide Range Of Flu Viruses Discovered | url = https://www.sciencedaily.com/releases/2009/02/090226141118.htm | work = ScienceDaily | date = 27 February 2009}}
* {{cite journal | vauthors = Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA | title = Antibody recognition of a highly conserved influenza virus epitope | journal = Science | location = New York, N.Y. | volume = 324 | issue = 5924 | pages = 246–51 | date = April 2009 | pmid = 19251591 | pmc = 2758658 | doi = 10.1126/science.1171491 | bibcode = 2009Sci...324..246E }}
{{refend}}


] ]
]
] ]


{{monoclonal-antibody-stub}} {{monoclonal-antibody-stub}}
{{antiinfective-drug-stub}} {{antiinfective-drug-stub}}

]

Latest revision as of 00:59, 13 September 2024

Monoclonal antibody Pharmaceutical compound
CR6261
Monoclonal antibody
Type?
SourceHuman
TargetInfluenza A hemagglutinin
Clinical data
Pregnancy
category
  • N/A
ATC code
  • none
Legal status
Legal status
  • Investigational (animal studies)
Identifiers
PubChem SID
ChemSpider
  • none
ChEMBL
  (what is this?)  (verify)

CR6261 is a monoclonal antibody that binds to a broad range of the influenza virus including the 1918 "Spanish flu" (SC1918/H1) and to a virus of the H5N1 class of avian influenza that jumped from chickens to a human in Vietnam in 2004 (Viet04/H5). In contrast to most antibodies generated by exposure to influenza, which can only neutralize a few strains from within a single virus subtype, CR6261 neutralizes numerous strains from multiple subtypes. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of hemagglutinin, the predominant protein on the surface of the influenza virus. Based upon the conservation of the amino acid sequence on this part of hemagglutinin, CR6261 is predicted to neutralize roughly 50% of all flu viruses. It was found by The Scripps Research Institute and the Dutch biopharmaceutical company, Crucell.

See also

References

  1. Friesen RH, Koudstaal W, Koldijk MH, Weverling GJ, Brakenhoff JP, Lenting PJ, et al. (February 2010). Zhang L (ed.). "New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets". PLOS ONE. 5 (2): e9106. Bibcode:2010PLoSO...5.9106F. doi:10.1371/journal.pone.0009106. PMC 2817000. PMID 20161706.

Further reading

Stub icon

This monoclonal antibody–related article is a stub. You can help Misplaced Pages by expanding it.

Stub icon

This antiinfective drug article is a stub. You can help Misplaced Pages by expanding it.

Categories: