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TAN-1057 A: Difference between revisions

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Revision as of 18:18, 26 September 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{chembox}} (no changed fields - added verified revid - updated 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Wikipedia_talk:WikiProject_Chemicals|error← Previous edit Latest revision as of 13:54, 9 January 2023 edit undoOzzie10aaaa (talk | contribs)Autopatrolled, Extended confirmed users, New page reviewers213,663 editsm Cleaned up using AutoEd 
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{{Chembox {{Chembox
| Verifiedfields = changed
| verifiedrevid = 401616968 | verifiedrevid = 470482351
| Name=TAN-1057 A <small>(top)</small> and TAN-1057 B <small>(bottom)</small>
| Name=TAN-1057 (A,&nbsp;B)
| ImageFile1 = TAN-1057A.png | ImageFile1 = TAN-1057A.png
| ImageSize1 = 200px | ImageSize1 =
| ImageCaption1 = TAN-1057 A
| ImageFile2 = TAN-1057B.png | ImageFile2 = TAN-1057B.png
| ImageSize2 = 200px | ImageSize2 =
| ImageCaption2 = TAN-1057 B
| IUPACName =
| OtherNames = | IUPACName =
| OtherNames =
| Section1 = {{Chembox Identifiers | Section1 = {{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = ZMWBCGMRXBPXEU-JGVFFNPUSA-N | StdInChIKey = ZMWBCGMRXBPXEU-JGVFFNPUSA-N
| CASNo1_Ref = {{cascite|changed|??}}
⚫ | CASNo = 128126-44-3
| CASOther = &nbsp;(TAN-1057 A)<br>128126-45-4 (TAN-1057 B) | CASNo1 = 128126-44-3
| CASNo1_Comment = (TAN-1057 A)
| CASNo2_Ref = {{cascite|changed|??}}
⚫ | CASNo2 = 128126-45-4
| CASNo2_Comment = (TAN-1057 B)
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 74EKN36H9V
| PubChem = 124498 | PubChem = 124498
| SMILES = O=C1N\C(=N/C1N(C(=O)C(N)CCC/N=C(\N)N)C)NC(=O)N | SMILES = O=C1N\C(=N/C1N(C(=O)C(N)CCC/N=C(\N)N)C)NC(=O)N
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| Section2 = {{Chembox Properties | Section2 = {{Chembox Properties
| C=13| H=25| N=9| O=3 | C=13| H=25| N=9| O=3
| Appearance = | Appearance =
| Density = | Density =
| MeltingPt = | MeltingPt =
| BoilingPt = | BoilingPt =
| Solubility = }} | Solubility = }}
| Section3 = {{Chembox Hazards | Section3 = {{Chembox Hazards
| MainHazards = | MainHazards =
| FlashPt = | FlashPt =
| Autoignition = }} | AutoignitionPt = }}
}} }}


'''TAN-1057 A''' and '''TAN-1057 B''' are organic compounds found in the ''] sp.'' PK-74 bacterium. TAN-1057 A and B are closely related structurally as ]s. Also related are ] and TAN-1057 D, isolated from the same bacteria. The four compounds have been shown to be an effective ]s against ]-resistant strains of '']'' which act through the inhibition of ] biosynthesis.<ref name=Katayama>{{cite journal | author=Katayama, N | title=TAN-1057 A-D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus. Taxonomy, fermentation and biological activity | journal=J. Antibiot. | year=1993 | pages=606–613 | volume=46 | issue=4 | pmid=8501003 | display-authors=1 | last2=Fukusumi | first2=S | last3=Funabashi | first3=Y | last4=Iwahi | first4=T | last5=Ono | first5=H}}</ref> '''TAN-1057 A''' and '''TAN-1057 B''' are organic compounds found in the ''] sp.'' PK-74 bacterium. TAN-1057 A and B are closely related structurally as ]s. Also related are ] and TAN-1057 D, isolated from the same bacteria. The four compounds have been shown to be an effective ]s against ]-resistant strains of '']'' which act through the inhibition of ] biosynthesis.<ref name=Katayama>{{cite journal | author=Katayama, N | title=TAN-1057 A-D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus. Taxonomy, fermentation and biological activity | journal=J. Antibiot. | year=1993 | pages=606–613 | volume=46 | issue=4 | pmid=8501003 | display-authors=1 | last2=Fukusumi | first2=S | last3=Funabashi | first3=Y | last4=Iwahi | first4=T | last5=Ono | first5=H | doi=10.7164/antibiotics.46.606| doi-access=free }}</ref>


==References== ==References==
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Latest revision as of 13:54, 9 January 2023

TAN-1057 (A, B)

TAN-1057 A

TAN-1057 B
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C13H25N9O3/c1-22(8-6-19-13(20-10(8)24)21-12(17)25)9(23)5-7(14)3-2-4-18-11(15)16/h7-8H,2-6,14H2,1H3,(H4,15,16,18)(H4,17,19,20,21,24,25)/t7-,8+/m0/s1Key: ZMWBCGMRXBPXEU-JGVFFNPUSA-N
  • InChI=1/C13H25N9O3/c1-22(8-6-19-13(20-10(8)24)21-12(17)25)9(23)5-7(14)3-2-4-18-11(15)16/h7-8H,2-6,14H2,1H3,(H4,15,16,18)(H4,17,19,20,21,24,25)/t7-,8+/m0/s1Key: ZMWBCGMRXBPXEU-JGVFFNPUBF
SMILES
  • O=C1N\C(=N/C1N(C(=O)C(N)CCC/N=C(\N)N)C)NC(=O)N
Properties
Chemical formula C13H25N9O3
Molar mass 355.403 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

TAN-1057 A and TAN-1057 B are organic compounds found in the Flexibacter sp. PK-74 bacterium. TAN-1057 A and B are closely related structurally as diastereomers. Also related are TAN-1057 C and TAN-1057 D, isolated from the same bacteria. The four compounds have been shown to be an effective antibiotics against methicillin-resistant strains of Staphylococcus aureus which act through the inhibition of protein biosynthesis.

References

  1. Katayama, N; et al. (1993). "TAN-1057 A-D, new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus. Taxonomy, fermentation and biological activity". J. Antibiot. 46 (4): 606–613. doi:10.7164/antibiotics.46.606. PMID 8501003.


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