| Revision as of 14:10, 2 November 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'CAS_number').← Previous edit |
Latest revision as of 13:13, 30 May 2023 edit undoEntranced98 (talk | contribs)Extended confirmed users, Pending changes reviewers, Rollbackers172,831 edits Adding local short description: "Monoclonal antibody", overriding Wikidata description "chemical compound"Tag: Shortdesc helper |
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{{Short description|Monoclonal antibody}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| Verifiedfields = changed |
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| verifiedrevid = 442241290 |
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| verifiedrevid = 458638230 |
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<!-- Monoclonal antibody data --> |
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<!--Monoclonal antibody data--> |
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| type = mab |
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| type = mab |
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| mab_type = mab |
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| mab_type = mab |
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| source = o |
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| source = o |
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| target = ] |
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| target = ] |
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<!-- Clinical data --> |
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| tradename = |
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<!--Clinical data--> |
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| tradename = |
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| pregnancy_AU = |
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| pregnancy_AU = |
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| pregnancy_US = |
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| pregnancy_US = |
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| pregnancy_category = |
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| pregnancy_category = |
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| legal_AU = |
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| legal_AU = |
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| legal_CA = |
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| legal_CA = |
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| legal_UK = |
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| legal_UK = |
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| legal_US = |
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| legal_US = |
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| legal_status = |
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| legal_status = |
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| routes_of_administration = ] |
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| routes_of_administration = ] |
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<!-- Pharmacokinetic data --> |
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| bioavailability = |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| protein_bound = |
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| protein_bound = |
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| metabolism = |
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| elimination_half-life = |
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| metabolism = |
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| excretion = |
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| elimination_half-life = |
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<!-- Identifiers --> |
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| excretion = |
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<!--Identifiers--> |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = NA |
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| ChemSpiderID = none |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number_Ref = {{cascite|changed|??}} |
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| CAS_number = <!-- blanked - oldvalue: 141410-98-2 --> |
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| CAS_number = 141410-98-2 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 01L0MVY85E |
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| ATC_prefix = none |
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| ATC_prefix = none |
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| ATC_suffix = |
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| ATC_suffix = |
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| PubChem = |
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| PubChem = |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| DrugBank = |
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<!-- Chemical data --> |
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| chemical_formula = |
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<!--Chemical data--> |
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| chemical_formula = |
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| molecular_weight = |
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| molecular_weight = |
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}} |
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}} |
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'''Edobacomab''', codenamed '''E5''', is a ] ] that was investigated as a possible treatment for ] caused by ]l infections. |
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'''Edobacomab''', codenamed '''E5''', is a ] ] that was investigated as a possible treatment for ] caused by ]l infections. |
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==Further reading== |
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== Further reading == |
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{{refbegin}} |
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*{{cite journal |author=Greenman RL |title=A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group |journal=JAMA |volume=266 |issue=8 |pages=1097–102 |year=1991 |month=August |pmid=1865542 |doi= 10.1001/jama.266.8.1097|url= |author-separator=, |author2=Schein RM |author3=Martin MA |display-authors=3 |last4=Wenzel |first4=RP |last5=MacIntyre |first5=NR |last6=Emmanuel |first6=G |last7=Chmel |first7=H |last8=Kohler |first8=RB |last9=McCarthy |first9=M}} |
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*{{cite journal |author=Bone RC |title=A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group |journal=Crit. Care Med. |volume=23 |issue=6 |pages=994–1006 |year=1995 |month=June |pmid=7774238 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0090-3493&volume=23&issue=6&spage=994 |author-separator=, |author2=Balk RA |author3=Fein AM |display-authors=3 |last4=Perl |first4=TM |last5=Wenzel |first5=RP |last6=Reines |first6=HD |last7=Quenzer |first7=RW |last8=Iberti |first8=TJ |last9=MacIntyre |first9=N}} |
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* {{cite journal | vauthors = Greenman RL, Schein RM, Martin MA, Wenzel RP, MacIntyre NR, Emmanuel G, Chmel H, Kohler RB, McCarthy M, Plouffe J | display-authors = 6 | title = A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group | journal = JAMA | volume = 266 | issue = 8 | pages = 1097–102 | date = August 1991 | pmid = 1865542 | doi = 10.1001/jama.266.8.1097 }} |
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* {{cite journal | vauthors = Bone RC, Balk RA, Fein AM, Perl TM, Wenzel RP, Reines HD, Quenzer RW, Iberti TJ, Macintyre N, Schein RM | display-authors = 6 | title = A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group | journal = Critical Care Medicine | volume = 23 | issue = 6 | pages = 994–1006 | date = June 1995 | pmid = 7774238 | doi = 10.1097/00003246-199506000-00003 }} |
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*{{cite journal |author=Angus DC |title=E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators |journal=JAMA |volume=283 |issue=13 |pages=1723–30 |year=2000 |month=April |pmid=10755499 |doi= 10.1001/jama.283.13.1723|url=http://jama.ama-assn.org/cgi/pmidlookup?view=long&pmid=10755499 |author-separator=, |author2=Birmingham MC |author3=Balk RA |display-authors=3 |last4=Scannon |first4=PJ |last5=Collins |first5=D |last6=Kruse |first6=JA |last7=Graham |first7=DR |last8=Dedhia |first8=HV |last9=Homann |first9=S}} |
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* {{cite journal | vauthors = Angus DC, Birmingham MC, Balk RA, Scannon PJ, Collins D, Kruse JA, Graham DR, Dedhia HV, Homann S, MacIntyre N | display-authors = 6 | title = E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators | journal = JAMA | volume = 283 | issue = 13 | pages = 1723–30 | date = April 2000 | pmid = 10755499 | doi = 10.1001/jama.283.13.1723 | doi-access = free }} |
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{{refend}} |
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{{Monoclonals for infectious disease and toxins}} |
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{{Monoclonals for infectious disease and toxins}} |
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] |
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] |
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] |
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{{antiinfective-drug-stub}} |
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{{antiinfective-drug-stub}} |
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{{monoclonal-antibody-stub}} |
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{{monoclonal-antibody-stub}} |
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] |
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