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{{Short description|Chemical compound}} | |||
{{Unreferenced|date=November 2009}} | |||
{{Drugbox | {{Drugbox | ||
| verifiedrevid = 437205813 | | verifiedrevid = 437205813 | ||
| IUPAC_name = 7- |
| IUPAC_name = 7-Chloro-3-quinazolin-4-one | ||
| image = Albaconazole.svg | | image = Albaconazole.svg | ||
<!--Clinical data--> | <!--Clinical data--> | ||
| tradename = |
| tradename = | ||
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | ||
| pregnancy_US = <!-- A / B |
| pregnancy_US = <!-- A / B / C / D / X --> | ||
| pregnancy_category = |
| pregnancy_category = | ||
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | ||
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> | | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> | ||
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> | | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> | ||
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | ||
| legal_status = |
| legal_status = | ||
| routes_of_administration = |
| routes_of_administration = | ||
<!--Pharmacokinetic data--> | <!--Pharmacokinetic data--> | ||
| bioavailability = |
| bioavailability = | ||
| protein_bound = |
| protein_bound = | ||
| metabolism = |
| metabolism = | ||
| elimination_half-life = |
| elimination_half-life = | ||
| excretion = |
| excretion = | ||
<!--Identifiers--> | <!--Identifiers--> | ||
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| CAS_number = 187949-02-6 | | CAS_number = 187949-02-6 | ||
| ATC_prefix = none | | ATC_prefix = none | ||
| ATC_suffix = |
| ATC_suffix = | ||
| ATC_supplemental = |
| ATC_supplemental = | ||
| PubChem = 208952 | | PubChem = 208952 | ||
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ||
| DrugBank = |
| DrugBank = | ||
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ||
| ChemSpiderID = 181045 | | ChemSpiderID = 181045 | ||
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<!--Chemical data--> | <!--Chemical data--> | ||
| chemical_formula = |
| chemical_formula = | ||
| C=20 | H=16 | Cl=1 | F=2 | N=5 | O=2 |
| C=20 | H=16 | Cl=1 | F=2 | N=5 | O=2 | ||
| molecular_weight = 431.823146 g/mol | |||
| smiles = Fc1ccc(c(F)c1)(O)((N3\C=N/c2cc(Cl)ccc2C3=O)C)Cn4ncnc4 | | smiles = Fc1ccc(c(F)c1)(O)((N3\C=N/c2cc(Cl)ccc2C3=O)C)Cn4ncnc4 | ||
| InChI = 1/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1 | |||
| InChIKey = UHIXWHUVLCAJQL-MPBGBICIBS | |||
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | ||
| StdInChI = 1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1 | | StdInChI = 1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1 | ||
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}} | }} | ||
'''Albaconazole (UR-9825 |
'''Albaconazole''' (development code '''UR-9825''') is an experimental ] antifungal.<ref>{{cite web | url = https://adisinsight.springer.com/drugs/800009452 | title = Albaconazole | work = Adis Insight | publisher = Springer Nature Switzerland AG }}</ref> It has potential broad-spectrum activity. The drug blocks a number of ] liver enzymes.{{cn|date=December 2022}} | ||
It has also been studied as an ] agent.<ref>{{cite journal | vauthors = Guedes PM, Urbina JA, de Lana M, Afonso LC, Veloso VM, Tafuri WL, Machado-Coelho GL, Chiari E, Bahia MT | display-authors = 6 | title = Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts | journal = Antimicrobial Agents and Chemotherapy | volume = 48 | issue = 11 | pages = 4286–92 | date = November 2004 | pmid = 15504854 | pmc = 525424 | doi = 10.1128/AAC.48.11.4286-4292.2004 }}</ref> | |||
⚫ | ] | ||
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] | |||
== References == | |||
{{Reflist}} | |||
⚫ | {{antiinfective-agent-stub}} | ||
{{Antifungals}} | {{Antifungals}} | ||
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] | |||
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] | |||
⚫ | {{antiinfective-agent-stub}} |
Latest revision as of 15:06, 16 March 2023
Chemical compound Pharmaceutical compoundClinical data | |
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ATC code |
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IUPAC name
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CAS Number | |
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ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.170.829 |
Chemical and physical data | |
Formula | C20H16ClF2N5O2 |
Molar mass | 431.83 g·mol |
3D model (JSmol) | |
SMILES
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InChI
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(verify) |
Albaconazole (development code UR-9825) is an experimental triazole antifungal. It has potential broad-spectrum activity. The drug blocks a number of CYP450 liver enzymes.
It has also been studied as an antiprotozoal agent.
References
- "Albaconazole". Adis Insight. Springer Nature Switzerland AG.
- Guedes PM, Urbina JA, de Lana M, Afonso LC, Veloso VM, Tafuri WL, et al. (November 2004). "Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts". Antimicrobial Agents and Chemotherapy. 48 (11): 4286–92. doi:10.1128/AAC.48.11.4286-4292.2004. PMC 525424. PMID 15504854.
This antiinfective drug article is a stub. You can help Misplaced Pages by expanding it. |