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{{Short description|Pharmaceutical drug}}
{{Orphan|date=February 2009}} {{More citations needed|date=February 2022}}
{{Drugbox {{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 447555440 | verifiedrevid = 447555440
| IUPAC_name = 1:1 mixture of 2-amino-2-methyl-1-propanol and 8-bromotheophyllinate | IUPAC_name = 1:1 mixture of 2-amino-2-methyl-1-propanol and 8-bromotheophyllinate
| image = Pamabrom.png | image = Pamabrom.svg


<!--Clinical data--> <!--Clinical data-->
| tradename = | tradename =
| Drugs.com = {{drugs.com|MTM|pamabrom}} | Drugs.com = {{drugs.com|MTM|pamabrom}}
| MedlinePlus = a681004 | MedlinePlus = a681004
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = | pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
| legal_US = OTC | legal_US = OTC
| legal_status = | legal_status =
| routes_of_administration = | routes_of_administration =


<!--Pharmacokinetic data--> <!--Pharmacokinetic data-->
| bioavailability = | bioavailability =
| protein_bound = | protein_bound =
| metabolism = | metabolism =
| elimination_half-life = | elimination_half-life =
| excretion = | excretion =


<!--Identifiers--> <!--Identifiers-->
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| CAS_number = 606-04-2 | CAS_number = 606-04-2
| ATC_prefix = none | ATC_prefix = none
| ATC_suffix = | ATC_suffix =
| PubChem = 11806 | PubChem = 11806
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 2104825
| DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = | DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 11313 | ChemSpiderID = 11313
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<!--Chemical data--> <!--Chemical data-->
| chemical_formula = 8-Bromotheophylline: C<sub>7</sub>H<sub>7</sub>BrN<sub>4</sub>O<sub>2</sub><br />2-Amino-2-methyl-1-propanol: C<sub>4</sub>H<sub>11</sub>NO | chemical_formula = 8-Bromotheophylline: C<sub>7</sub>H<sub>7</sub>BrN<sub>4</sub>O<sub>2</sub><br />2-Amino-2-methyl-1-propanol: C<sub>4</sub>H<sub>11</sub>NO

| molecular_weight = 348.20 | molecular_weight = 348.20
| molecular_weight_comment = g/mol
| smiles = O=C2N(c1nc(Br)nc1C(=O)N2C)C.OCC(N)(C)C | smiles = Cn2c(=O)c1c(Br)nc1n(C)c2=O.NC(C)(C)CO
| InChI = 1/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3
| InChIKey = ATOTUUBRFJHZQG-UHFFFAOYAD
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3 | StdInChI = 1S/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3
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}} }}


'''Pamabrom''' (trade name '''Diurex''') is a ] product included in retail ]s available in over-the-counter medications. The active diuretic ingredient in pamabrom is ]. '''Pamabrom''', manufactured by ], is a product included in retail ]s available in over-the-counter medications. The active diuretic ingredient in pamabrom is ] and it also contains ].

⚫ Pamabrom is available in combination with ] (paracetamol) for various conditions such as back pain and menstrual relief.<ref name="pmid15013925">{{cite journal | vauthors = Di Girolamo G, Sánchez AJ, De Los Santos AR, González CD | title = Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea? | journal = Expert Opinion on Pharmacotherapy | volume = 5 | issue = 3 | pages = 561–70 | date = March 2004 | pmid = 15013925 | doi = 10.1517/14656566.5.3.561 | s2cid = 26876035 }}</ref> The acetaminophen helps reduce ] pains and the pamabrom reduces associated bloating. The combination is available in a number of products from various brands under different names. The dosages are essentially the same for each brand, including ] store varieties.


A ] is also used to reduce edema (fluid buildup) in the body. Edema can cause swelling of the extremities, such as in the hands and feet. Edema can make it harder for the heart to work properly, and it can be related to ].
⚫ Pamabrom is available in combination with ] (paracetamol) for various conditions such as back pain and menstrual relief. The acetaminophen helps reduce ] pains and the pamabrom reduces associated bloating. The combination is available in a number of products from various brands under different names. The dosages are essentially the same for each brand, including generic drug store varieties.


==References== ==References==
{{Reflist}}


== External links == == External links ==
⚫ * {{Webarchive|url=https://web.archive.org/web/20080312211246/http://www.medicinenet.com/script/main/art.asp?articlekey=52104 |date=2008-03-12 }}
*
*
⚫ *


] ]

Latest revision as of 21:35, 28 June 2024

Pharmaceutical drug
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.
Find sources: "Pamabrom" – news · newspapers · books · scholar · JSTOR (February 2022) (Learn how and when to remove this message)
Pharmaceutical compound
Pamabrom
Clinical data
AHFS/Drugs.comMultum Consumer Information
MedlinePlusa681004
ATC code
  • none
Legal status
Legal status
Identifiers
IUPAC name
  • 1:1 mixture of 2-amino-2-methyl-1-propanol and 8-bromotheophyllinate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.009.186 Edit this at Wikidata
Chemical and physical data
Formula8-Bromotheophylline: C7H7BrN4O2
2-Amino-2-methyl-1-propanol: C4H11NO
Molar mass348.20 g/mol
3D model (JSmol)
SMILES
  • Cn2c(=O)c1c(Br)nc1n(C)c2=O.NC(C)(C)CO
InChI
  • InChI=1S/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3
  • Key:ATOTUUBRFJHZQG-UHFFFAOYSA-N
  (what is this?)  (verify)

Pamabrom, manufactured by Chattem Chemicals, is a product included in retail drugs available in over-the-counter medications. The active diuretic ingredient in pamabrom is 8-bromotheophylline and it also contains aminoisobutanol.

Pamabrom is available in combination with acetaminophen (paracetamol) for various conditions such as back pain and menstrual relief. The acetaminophen helps reduce menstrual pains and the pamabrom reduces associated bloating. The combination is available in a number of products from various brands under different names. The dosages are essentially the same for each brand, including generic drug store varieties.

A diuretic is also used to reduce edema (fluid buildup) in the body. Edema can cause swelling of the extremities, such as in the hands and feet. Edema can make it harder for the heart to work properly, and it can be related to congestive heart failure.

References

  1. Di Girolamo G, Sánchez AJ, De Los Santos AR, González CD (March 2004). "Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea?". Expert Opinion on Pharmacotherapy. 5 (3): 561–70. doi:10.1517/14656566.5.3.561. PMID 15013925. S2CID 26876035.

External links


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