Ilepcimide: Difference between revisions

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			{{Short description\|Chemical compound}}
	{{Drugbox		{{Drugbox
			\| Verifiedfields = changed
⚫	\| verifiedrevid = ~~444303212~~
			\| Watchedfields = changed
⚫	\| IUPAC_name = (E)-3-(1,3-~~benzodioxol~~-5-yl)-1-piperidin-1-~~ylprop~~-2-en-1-one
		⚫	\| verifiedrevid = 451225156
		⚫	\| IUPAC_name = (2''E'')-3-(2''H''-1,3-Benzodioxol-5-yl)-1-(piperidin-1-yl)prop-2-en-1-one
	\| image = Ilepcimide.png		\| image = Ilepcimide.png
	\| width = 200px		\| width = 200px

	<!--Clinical data-->		<!--Clinical data-->
	\| tradename =		\| tradename =
	\| pregnancy_category =		\| pregnancy_category =
	\| legal_status =		\| legal_status =
	\| routes_of_administration =		\| routes_of_administration =

	<!--Pharmacokinetic data-->		<!--Pharmacokinetic data-->
	\| bioavailability =		\| bioavailability =
	\| metabolism =		\| metabolism =
	\| elimination_half-life =		\| elimination_half-life =
	\| excretion =		\| excretion =

	<!--Identifiers-->		<!--Identifiers-->
			\| CAS_number_Ref = {{cascite\|correct\|??}}
	\| CAS_number = ~~23434~~-86-8		\| CAS_number = 82857-82-7
	\| ATC_prefix = none		\| ATC_prefix = none
	\| ATC_suffix =		\| ATC_suffix =
	\| PubChem = 641115		\| PubChem = 641115
	\| UNII_Ref = {{fdacite\|correct\|FDA}}		\| UNII_Ref = {{fdacite\|correct\|FDA}}
	\| UNII = 5ML58O200F		\| UNII = 5ML58O200F
			\| ChemSpiderID_Ref = {{chemspidercite\|changed\|chemspider}}
	\| PubChem = 641115
	\| ChemSpiderID = 556435		\| ChemSpiderID = 556435
			\| StdInChI_Ref = {{stdinchicite\|changed\|chemspider}}
	\| ~~InChI~~ = 1/C15H17NO3/c17-15(16-8-2-1-3-9-16)7-5-12-4-6-13-14(10-12)19-11-18-13/h4-7,10H,1-3,8-9,11H2/b7-5+		\| StdInChI = 1S/C15H17NO3/c17-15(16-8-2-1-3-9-16)7-5-12-4-6-13-14(10-12)19-11-18-13/h4-7,10H,1-3,8-9,11H2/b7-5+
	\| InChIKey = BLPUOQGPBJPXRL-FNORWQNLBF
			\| StdInChIKey_Ref = {{stdinchicite\|changed\|chemspider}}
	\| StdInChI = 1S/C15H17NO3/c17-15(16-8-2-1-3-9-16)7-5-12-4-6-13-14(10-12)19-11-18-13/h4-7,10H,1-3,8-9,11H2/b7-5+
	\| StdInChIKey = BLPUOQGPBJPXRL-FNORWQNLSA-N		\| StdInChIKey = BLPUOQGPBJPXRL-FNORWQNLSA-N

	<!--Chemical data-->		<!--Chemical data-->
	\| C=15 \| H=17 \| N=1 \| O=3		\| C=15 \| H=17 \| N=1 \| O=3
	\| molecular_weight = 259.300 g/mol
	\| smiles = C1CCN(CC1)C(=O)/C=C/C2=CC3=C(C=C2)OCO3		\| smiles = C1CCN(CC1)C(=O)/C=C/C2=CC3=C(C=C2)OCO3
	}}		}}

			'''Ilepcimide''', also known as '''antiepilepserine''', is an ].<ref name="GanellinTriggle1996">{{cite book \| vauthors = Ganellin CR, Triggle DJ \| title = Dictionary of Pharmacological Agents \| url = https://books.google.com/books?id=A0THacd46ZsC&pg=PA1116 \| accessdate = 30 November 2012 \| date = 21 November 1996 \| publisher = CRC Press \| isbn = 978-0-412-46630-4 \| page = 1116}}</ref> It is a ] ] that was first synthesized by Chinese researchers as an ] of ], the main pungent compound and ] of ] (and of other plants in the family ]).
	'''Ilepcimide''' ('''Antiepilepserine''') is a ] ] used in ].

			Ilepcimide has ] activity.<ref name="GanellinTriggle1996" /><ref>{{cite journal \| vauthors = Liu GQ, Algeri S, Ceci A, Garattini S, Gobbi M, Murai S \| title = Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative \| journal = Biochemical Pharmacology \| volume = 33 \| issue = 23 \| pages = 3883–6 \| date = December 1984 \| pmid = 6210090 \| doi = 10.1016/0006-2952(84)90055-8 \| doi-access = free }}</ref><ref>{{cite journal \| vauthors = Yan QS, Mishra PK, Burger RL, Bettendorf AF, Jobe PC, Dailey JW \| title = Evidence that carbamazepine and antiepilepsirine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats \| journal = The Journal of Pharmacology and Experimental Therapeutics \| volume = 261 \| issue = 2 \| pages = 652–9 \| date = May 1992 \| pmid = 1374472 }}</ref>

			==See also==
			* ]

	== References ==		== References ==
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	{{Anticonvulsants}}		{{Anticonvulsants}}

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Latest revision as of 13:21, 7 November 2023

Chemical compound Pharmaceutical compound

Ilepcimide
Clinical data

ATC code	none
Identifiers
IUPAC name (2E)-3-(2H-1,3-Benzodioxol-5-yl)-1-(piperidin-1-yl)prop-2-en-1-one
CAS Number	82857-82-7
PubChem CID	641115
ChemSpider	556435
UNII	5ML58O200F
Chemical and physical data
Formula	C₁₅H₁₇NO₃
Molar mass	259.305 g·mol
3D model (JSmol)	Interactive image
SMILES C1CCN(CC1)C(=O)/C=C/C2=CC3=C(C=C2)OCO3
InChI InChI=1S/C15H17NO3/c17-15(16-8-2-1-3-9-16)7-5-12-4-6-13-14(10-12)19-11-18-13/h4-7,10H,1-3,8-9,11H2/b7-5+ Key:BLPUOQGPBJPXRL-FNORWQNLSA-N
(what is this?) (verify)

Ilepcimide, also known as antiepilepserine, is an anticonvulsant. It is a piperidine derivative that was first synthesized by Chinese researchers as an analogue of piperine, the main pungent compound and phytochemical of black pepper (and of other plants in the family Piperaceae).

Ilepcimide has serotonergic activity.

References

^ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. p. 1116. ISBN 978-0-412-46630-4. Retrieved 30 November 2012.
Liu GQ, Algeri S, Ceci A, Garattini S, Gobbi M, Murai S (December 1984). "Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative". Biochemical Pharmacology. 33 (23): 3883–6. doi:10.1016/0006-2952(84)90055-8. PMID 6210090.
Yan QS, Mishra PK, Burger RL, Bettendorf AF, Jobe PC, Dailey JW (May 1992). "Evidence that carbamazepine and antiepilepsirine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats". The Journal of Pharmacology and Experimental Therapeutics. 261 (2): 652–9. PMID 1374472.

Anticonvulsants (N03)

GABAergics

GABA_AR PAMs	Barbiturates: Barbexaclone Metharbital Methylphenobarbital Pentobarbital Phenobarbital Primidone; Carbamates: Cenobamate Felbamate; Benzodiazepines: Clobazam Clonazepam Clorazepate Diazepam Lorazepam Midazolam Nimetazepam Nitrazepam Temazepam; Others: Bromide (potassium bromide, sodium bromide) Imepitoin Paraldehyde Stiripentol
GABA-T inhibitors	Fatty acids (and related): Valproate Valpromide Valproate pivoxil Vigabatrin
Others	GABAR agonists: Progabide; GAT-1 inhibitors: Tiagabine

Channel
modulators

Sodium blockers	Hydantoins: Ethotoin Fosphenytoin Mephenytoin Phenytoin; Ureides: Acetylpheneturide Chlorphenacemide Phenacemide Pheneturide; Fatty acids: Valproate Valpromide Valproate pivoxil; Carboxamides: Carbamazepine Eslicarbazepine acetate Oxcarbazepine; Others: Lacosamide Lamotrigine Rufinamide Topiramate Zonisamide
Calcium blockers	Oxazolidinediones: Ethadione Paramethadione Trimethadione; Succinimides: Ethosuximide Mesuximide Phensuximide; Gabapentinoids: Gabapentin Pregabalin; Others: Imepitoin Lamotrigine Topiramate Zonisamide
Potassium openers	Retigabine

Others

CA inhibitors	Sulfonamides: Acetazolamide Ethoxzolamide Sultiame Topiramate Zonisamide
Others	Albutoin Beclamide Brivaracetam Cannabidiol Carisbamate Etiracetam Fenfluramine Ganaxolone Levetiracetam Perampanel

WHO-EM
Withdrawn from market
Clinical trials:
- Phase III
- Never to phase III

This anticonvulsant-related article is a stub. You can help Misplaced Pages by expanding it.

Categories:

Latest revision as of 13:21, 7 November 2023

See also

References