| Revision as of 11:02, 20 February 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,084 edits Saving copy of the {{drugbox}} taken from revid 469541507 of page Treprostinil for the Chem/Drugbox validation project (updated: 'ChEMBL', 'CAS_number').← Previous edit |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}} |
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{{Drugbox |
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{{drugbox |
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| verifiedrevid = 477001424 |
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| Verifiedfields = changed |
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| IUPAC_name = 2-Oxo-<small>L</small>-threo-hexono-1,4-lactone-2,3-enediol<br />''or''<br />(''R'')-3,4-dihydroxy-5-((''S'')- 1,2-dihydroxyethyl)furan-2(5''H'')-one |
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| verifiedrevid = 431682874 |
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| image = L-Ascorbic_acid.svg |
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| IUPAC_name = (1''R'',2''R'',3a''S'',9a''S'')-<nowiki>-1''H''-benzinden-5-yl]<br>oxy]acetic acid |
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| width = 200px |
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| image = Treprostinil.svg |
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| image2 = Treprostinil2.png |
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| image2 = Ascorbic-acid-from-xtal-1997-3D-balls.png |
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| width2 = 200px |
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<!--Clinical data--> |
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<!--Clinical data--> |
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| Drugs.com = {{drugs.com|MTM|vitamin_c}} |
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| tradename = Remodulin, Tyvaso |
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| licence_EU = <!-- EMEA requires brand name --> |
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| Drugs.com = {{drugs.com|CONS|treprostinil}} |
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| licence_US = <!-- FDA may use generic name --> |
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| MedlinePlus = a600042 |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_category = B |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| legal_status = Rx-only |
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| pregnancy_category = A |
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| routes_of_administration = ] or ], inhalation |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = general public availability |
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| routes_of_administration = oral |
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<!--Pharmacokinetic data--> |
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<!--Pharmacokinetic data--> |
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| bioavailability = approximately 100% |
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| bioavailability = rapid & complete |
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| protein_bound = negligible |
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| metabolism = Treprostinil is substantially metabolized by the liver, but the involved enzymes are not currently known. Five metabolites (HU1 through HU5) have been described thus far. Based on the results of in vitro human hepatic cytochrome P450 studies, Remodulin does not inhibit CYP-1A2, 2C9, 2C19, 2D6, 2E1, or 3A. Whether Remodulin induces these enzymes has not been studied. |
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| elimination_half-life = 4 hours |
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| elimination_half-life = varies according to plasma concentration <!-- can be 30 min to weeks, depending on body stores --> |
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| excretion = renal |
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| excretion = Urine (79 % of administered dose is excreted in the urine as 4% unchanged drug and 64% as identified metabolites); feces (13%) |
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<!--Identifiers--> |
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<!--Identifiers--> |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = <!-- blanked - oldvalue: 289480-64-4 --> |
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| CAS_number = 50-81-7 |
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| ATC_prefix = B01 |
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| ATC_prefix = A |
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| ATC_suffix = AC21 |
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| ATC_suffix = 11G |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| PubChem = 6918140 |
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| ChEBI = 29073 |
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| DrugBank_Ref = {{drugbankcite|changed|drugbank}} |
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| DrugBank = DB00374 |
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| PubChem = 5785 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = DB00126 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 5293353 |
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| ChemSpiderID = 10189562 |
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| NIAID_ChemDB = 002072 |
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| UNII_Ref = {{fdacite|changed|FDA}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = RUM6K67ESG |
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| UNII = PQ6CK8PD0R |
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| ChEBI_Ref = {{ebicite|changed|EBI}} |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| ChEBI = 50861 |
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| KEGG = D00018 |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = <!-- blanked - oldvalue: 1201254 --> |
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| ChEMBL = 196 |
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| C=23 | H=34 | O=5 |
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<!--Chemical data--> |
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| molecular_weight = relative molecular weight is 390.52 g/mol. |
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| chemical_formula = |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| C=6 | H=7 | O=6 |
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| StdInChI = 1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1 |
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| molecular_weight = 176.12 g/] |
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| smiles = C((1C(=C(C(=O)O1)O)O)O)O |
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| InChI = 1/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = PAJMKGZZBBTTOY-ZFORQUDYSA-N |
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| StdInChIKey = CIWBSHSKHKDKBQ-JLAZNSOCSA-N |
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| synonyms = <small>L</small>-ascorbic acid |
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| density = 1.694 |
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| melting_point = 190 |
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| boiling_point = 553 |
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}} |
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}} |
