Hydroxymethylglutaryl-CoA reductase: Difference between revisions

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	{{Infobox enzyme		{{Infobox enzyme
	\| Name = Hydroxymethylglutaryl-CoA reductase		\| Name = Hydroxymethylglutaryl-CoA reductase
	\| EC_number = 1.1.1.88		\| EC_number = 1.1.1.88
	\| CAS_number = 37250-24-1		\| CAS_number = 37250-24-1
			\| GO_code =
	\| IUBMB_EC_number = 1/1/1/88
	\| ~~GO_code~~ =		\| image =
	\| ~~image~~ =		\| width =
	\| ~~width~~ =		\| caption =
	\| caption =
	}}		}}
			In ], a '''Hydroxymethylglutaryl-CoA reductase''' ({{EC number\|1.1.1.88}}) is an ] that ] the ]
	'''Hydroxymethylglutaryl-CoA reductase''' ({{EC number\|1.1.1.88}}, ''beta-hydroxy-beta-methylglutaryl coenzyme A reductase'', ''beta-hydroxy-beta-methylglutaryl CoA-reductase'', ''3-hydroxy-3-methylglutaryl coenzyme A reductase'', ''hydroxymethylglutaryl coenzyme A reductase'') is an ] with system name ''(R)-mevalonate:NAD<sup>+</sup> oxidoreductase (CoA-acylating)''.<ref>{{cite journal \| title = Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA) \|author = Fimognari, G.M. and Rodwell, V.W. \|journal = Biochemistry \|year = 1965 \|volume = 4 \|pages = 2086–2090 \|pmid = }}</ref> This enzyme ] the following ]

	: (R)-mevalonate + CoA + 2 NAD<sup>+</sup> <math>\rightleftharpoons</math> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H<sup>+</sup>		: (R)-mevalonate + CoA + 2 NAD<sup>+</sup> <math>\rightleftharpoons</math> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H<sup>+</sup>

			The 3 ] of this enzyme are (R)-], ], and ], whereas its 3 ] are ], ], and ].

			This enzyme belongs to the family of ]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The ] of this enzyme class is '''(R)-mevalonate:NAD<sup>+</sup> oxidoreductase (CoA-acylating)'''.<ref>{{cite journal \| title = Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA) \| vauthors = Fimognari GM, Rodwell VW \|journal = Biochemistry \|year = 1965 \|volume = 4 \| issue = 10 \|pages = 2086–2090 \|doi=10.1021/bi00886a025}}</ref> Other names in common use include '''beta-hydroxy-beta-methylglutaryl coenzyme A reductase''', '''beta-hydroxy-beta-methylglutaryl CoA-reductase''', '''3-hydroxy-3-methylglutaryl coenzyme A reductase''', and '''hydroxymethylglutaryl coenzyme A reductase'''.

	== References ==		== References ==
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	== External links ==		== External links ==
	* {{MeshName\|Hydroxymethylglutaryl-CoA+reductase}}		* {{MeshName\|Hydroxymethylglutaryl-CoA+reductase}}

			{{Alcohol oxidoreductases}}
			{{Enzymes}}
			{{Portal bar\|Biology\|border=no}}

	]		]
			]
			]


			{{1.1.1-enzyme-stub}}

Latest revision as of 14:30, 26 August 2023

Hydroxymethylglutaryl-CoA reductase

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In enzymology, a Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) is an enzyme that catalyzes the chemical reaction

(R)-mevalonate + CoA + 2 NAD

\rightleftharpoons

3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H

The 3 substrates of this enzyme are (R)-mevalonate, CoA, and NAD, whereas its 3 products are 3-hydroxy-3-methylglutaryl-CoA, NADH, and H.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD oxidoreductase (CoA-acylating). Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl coenzyme A reductase.

References

Fimognari GM, Rodwell VW (1965). "Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA)". Biochemistry. 4 (10): 2086–2090. doi:10.1021/bi00886a025.

External links

Hydroxymethylglutaryl-CoA+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor	3-hydroxyacyl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydrogenase Alcohol dehydrogenase Aldo-keto reductase 1A1 1B1 1B10 1C1 1C3 1C4 7A2 Aldose reductase Beta-Ketoacyl ACP reductase Carbohydrate dehydrogenases Carnitine dehydrogenase D-malate dehydrogenase (decarboxylating) DXP reductoisomerase Glucose-6-phosphate dehydrogenase Glycerol-3-phosphate dehydrogenase HMG-CoA reductase IMP dehydrogenase Isocitrate dehydrogenase Lactate dehydrogenase L-threonine dehydrogenase L-xylulose reductase Malate dehydrogenase Malate dehydrogenase (decarboxylating) Malate dehydrogenase (NADP+) Malate dehydrogenase (oxaloacetate-decarboxylating) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) Phosphogluconate dehydrogenase Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3β 3β-HSD NSDHL 11β 11β-HSD1 11β-HSD2 17β
1.1.2: cytochrome acceptor	D-lactate dehydrogenase (cytochrome) D-lactate dehydrogenase (cytochrome c-553) Mannitol dehydrogenase (cytochrome)
1.1.3: oxygen acceptor	Glucose oxidase L-gulonolactone oxidase Xanthine oxidase Alcohol oxidase
1.1.4: disulfide as acceptor	Vitamin K epoxide reductase Vitamin-K-epoxide reductase (warfarin-insensitive)
1.1.5: quinone/similar acceptor	Malate dehydrogenase (quinone) Quinoprotein glucose dehydrogenase
1.1.99: other acceptors	Choline dehydrogenase L2HGDH

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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